Comorbidities and outcomes among patients hospitalized with COVID-19 in Upper Egypt (original) (raw)
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Impact of comorbidities on COVID-19 outcome
Background and aimsThe coronavirus disease 19 (COVID-19) pandemic has spread rapidly around the globe with considerable morbidity and mortality. Coexistence of comorbidities with COVID-19 have consistently been reported as risk factors for unfavorable prognosis. We aim at this study to evaluate the impact of comorbidities in COVID-19 patients on the outcome and determine predictors of prolonged hospital stay, requisite for ICU admission or decease.MethodsFour hundreds and thirty nine adult patients who are admitted through (June and July 2020) in Assiut and Aswan University Hospitals were included in the study. All participants were diagnosed with COVID-19 according to Egyptian Ministry of Health guidance as definite case or Probable case. Detection of SARS-CoV-2 RNA was done by (TaqMan™ 2019-nCoV Control Kit v1 (Cat. No. A47532) supplied by QIAGEN, Germany on the Applied Biosystem 7500 Fast RT PCR System, USA.ResultsPatients with comorbidities represented 61.7% of all cases. Consti...
PLOS ONE, 2021
Objectives We conducted the present multicenter, retrospective study to assess the epidemiological, clinical, laboratory, and radiological characteristics associated with critical illness among patients with COVID-19 from Egypt. Methods The present study was a multicenter, retrospective study that retrieved the data of all Egyptian cases with confirmed COVID-19 admitted to hospitals affiliated to the General Organization for Teaching Hospitals and Institutes (GOTHI) through the period from March to July 2020. The diagnosis of COVID-19 was based on a positive reverse transcription-polymerase chain reaction (RT-PCR) laboratory test. Results This retrospective study included 2724 COVID-19 patients, of whom 423 (15.52%) were critically ill. Approximately 45.86% of the critical group aged above 60 years, compared to 39.59% in the non-critical group (p = 0.016). Multivariate analysis showed that many factors were predictors of critically illness, including age >60 years (OR = 1.30, 95%...
Afro-Egyptian Journal of Infectious and Endemic Diseases, 2021
Shimaa El Sharawy, Ibrahim Amer, Marwa Salama, Walaa El-Lawaty, Mohamed Abd Elghafar, Amany Ghazi, Nehad Hawash Department of Tropical Medicine and Infectious Diseases, Faculty of Medicine, Tanta University, Egypt. Department of Hepatology, Gastroenterology and Infectious Diseases, Faculty of Medicine, Kafr El Sheikh University, Egypt. Department of Chest Diseases, Faculty of Medicine, Tanta University, Egypt. Department of Anesthesia, Surgical Intensive Care and Pain Management, Tanta University, Egypt. Department of Microbiology and Medical Immunology, Faculty of Medicine, Kafr El Sheikh University, Egypt.
2020
BackgroundDefining the clinical features and associated outcomes of patients diagnosed with corona virus disease (COVID-19) is fundamental to improving our understanding and adequate management of this illness. The aim of this study was to identify the demographic data, underlying comorbidities and the mortality related factors of hospitalized patients with COVID-19 in Upper Egypt.Patients and methods1064 cases consecutively admitted to isolation hospitals in Upper Egypt. All cases had confirmed COVID-19 infection. The electronic records of the patients were retrospectively revised and the demographic data, clinical manifestations, qSOFA score on admission and 30 days-outcome (ICU admission, death, recovery, referral or still in hospital) were analyzed. Overall cumulative survival in all patients and those > or < 50 years were calculated.Results49.2% of the study population were males and 50.8% were females with mean age 49.4±17.8 years-old. On admission, 83.9% were stable wit...
Journal of research in clinical medicine, 2022
Introduction Coronavirus disease 2019 (COVID-19) is an acute respiratory syndrome that has outspread to most countries in a few months. The burden of COVID-19 has been on the increase globally. 1 Since December 2019, more than 137 million people have been infected, with approximately 3 million deaths. 2 Patients with COVID-19 mainly have a fever, myalgia or fatigue, and dry cough. Although most patients are believed to have a favorable prognosis, elderly patients and those with chronic diseases are at risk for more severe illness and mortality. Patients who have the severe disease might develop shortness of breath and hypoxemia within one week of the onset of the disease, which can rapidly progress to acute respiratory distress syndrome (ARDS) or organ failure. 3 Initial analysis of patients hospitalized in China with COVID-19 have shown that diabetes, hypertension, and cardiovascular diseases are very common among them, and patients with these comorbidities are more exposed to have poor clinical outcomes. 4 In a recent study of 201 patients with COVID-19 pneumonia, risk factors associated with ARDS development and progression from ARDS to death included age, neutrophilia, organ dysfunction, and coagulation disorders. 3 The time of clearance of coronavirus RNA depended on sex, disease severity, and lymphocyte function. 5 The clinical spectrum of COVID-19 infection is wide, including asymptomatic infection, mild upper respiratory tract disease, and severe viral pneumonia associated
Short communication, 2022
The current Coronavirus Disease 2019 (COVID-19) pandemic that emerged in December 2019 in China continues to claim a thousand lives worldwide. This study aimed to report characteristics and inhospital outcomes of a Moroccan COVID-19 cohort, and identify factors which predispose patients to hospitalization and mortality from COVID-19. We conducted a cross-sectional study of symptomatic COVID-19 patients referred to COVID-19 ward of the Settat Provincial Hospital, during October 2020. A confirmed COVID-19 case was defined by a positive detection of SARS-CoV-2 genome using real-time RT-PCR assay performed on nasopharyngeal swabs. Patients´ demographic and clinical characteristics were collected and analyzed using SPSS V22.0. Univariate followed by multivariate logistic regression analysis was performed to identify factors associated with mortality due to COVID-19. In total, 269 patients were reported. The median age was 64 years [IQR 54-73], 48.7% were elderly (≥ 65 years), 51.7% were men, and the case-fatality rate (CFR) was 5.58%. Males had a higher CFR (6.5%) than females (4.6%). In deceased people: 60% males, 73.3% were elderly, and oxygen saturation values of 90% or less on admission were more frequent (86.7%) than in recovered ones (10.9%). Most patients (80.3%) had at least one comorbidity: 100% of deaths, 59% older than 60 years, CFR was 6.94% and the most prevalent diseases were diabetes (54.6%), hypertension (41.7%), and cardiac disease (40.7%). The most common symptoms on presentation were dyspnea (67.7%), fever (65.4%) and cough (58.4%). Multivariable logistic regression analysis showed that only older age (AOR: 10.860, 95% CI: 3.382-34.86; p<0.001) and cardiac disease (AOR: 0.244, 95% CI: 0.074-0.799; p=0.02) were associated with higher mortality rates. Categorizing patients at admission according to risk factors identified by multivariate and also univariate analyses (mainly dyspnea) is essential to help in deciding the hospitalization priority and the strategy that will eventually reduce death risk.
Comorbidity and its Impact on Patients with COVID-19
SN Comprehensive Clinical Medicine, 2020
A novel human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified in Wuhan, China, in December 2019. Since then, the virus has made its way across the globe to affect over 180 countries. SARS-CoV-2 has infected humans in all age groups, of all ethnicities, both males and females while spreading through communities at an alarming rate. Given the nature of this virus, there is much still to be learned; however, we know that the clinical manifestations range from a common cold to more severe diseases such as bronchitis, pneumonia, severe acute respiratory distress syndrome (ARDS), multi-organ failure, and even death. It is believed that COVID-19, in those with underlying health conditions or comorbidities, has an increasingly rapid and severe progression, often leading to death. This paper examined the comorbid conditions, the progression of the disease, and mortality rates in patients of all ages, infected
Prevalence of Comorbidities in COVID-19 Patients
Journal of Management & Science
Coronaviruses are known to cause fatal diseases like Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS) and recently recognised coronavirus disease 19 (COVID-19). It is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a single-stranded RNA virus. This review is done to study the clinical presentation, comorbid conditions in COVID-19 patients. The relevant articles were searched in PubMed, Science direct and special issues in JAMA, and the New England Journal of Medicine. Only selected papers were used for data extraction and synthesis. The exact source of current pandemic of Covid-19 is not known. The main clinical symptoms include fever, dry cough, myalgia, dyspnoea. Other symptoms presented are headache, malaise, chills/rigor and diarrhoea. The mortality rate was high in above 60 years of age with the comorbid conditions. The data analysis revealed varied mortality rates in different regions. The mortality...
Journal of Infection and Public Health, 2020
Introduction: The ongoing pandemic of the coronavirus disease 2019 (COVID-19) is a global health concern. It has affected more than 5 million patients worldwide and resulted in an alarming number of deaths globally. While clinical characteristics have been reported elsewhere, data from our region is scarce. We investigated the clinical characteristics of mild to moderate cases of COVID-19 in Saudi Arabia. Methods: This is a descriptive, cross-sectional study. Data of 401 confirmed COVID-19 patients were collected from 22 April 2020 to 21 May 2020 at five tertiary care hospitals in Riyadh, Saudi Arabia. The patients were divided into four groups according to age, Group 1: 0-<18 years, Group 2: 18-<50 years, Group 3: 50-60 years, and Group 4: >60 years; and their clinical symptoms were compared. Results: The median (IQR) age in years was 10.5 (1.5−16) in group I, 34 (29−41) in group II, 53 (51−56) in group III, and 66 (61−76) in group IV. Most patients were male (80%, n = 322) and of Arabian or Asian descent. The median length of stay in the hospital was 10 (8-17) days (range 3-42 days). The most common symptoms were cough (53.6%), fever (36.2%), fatigue (26.4%), dyspnea (21.9%), and sore throat (21.9%). Hypertension was the most common underlying comorbidity (14.7%), followed by obesity (11.5%), and diabetes (10%). Hypertensive patients were less likely to present with shortness of breath, cough, sputum, diarrhea, and fever. Conclusion: There was no significant difference in the symptoms among different age groups and comorbidities were mostly seen in the older age group. Interestingly, hypertensive patients were found to have milder symptoms and a shorter length of stay. Further larger collaborative national studies are required to effectively understand clinical characteristics in our part of the world to efficiently manage and control the spread of SARS-CoV-2.
Characteristics of critically ill patients infected with COVID-19 in Abu Dhabi, United Arab Emirates
Anaesthesia Critical Care & Pain Medicine, 2020
, a novel coronavirus SARS-CoV-2 emerged in Wuhan city and extended around the globe. As of June 26, 2020, approximately 46,563 confirmed cases have been documented in the United Arab Emirates (UAE), with 308 deaths [1]. There are no reports describing patients admitted to the intensive care unit (ICU) with COVID-19 in the UAE. This study's primary objective was to describe the clinical characteristics of patients with laboratory-confirmed COVID-19 admitted to the ICU at Cleveland Clinic Abu Dhabi. A retrospective study was conducted for this purpose. A waiver of informed consent was obtained from the Ethics Committee at Cleveland Clinic Abu Dhabi (number: A-2020-035). All consecutive adult patients admitted to our ICU between March 31 and May 10, 2020, with confirmed SARS-CoV-2 infection (virus detected by a real time reverse transcriptase-polymerase chain reaction assay of a nasopharyngeal sample) were included. De-identified data from the electronic medical record were collected: comorbidities, laboratory data at ICU admission, arterial blood gas and respiratory mechanics data on admission and during the first 3 days. Continuous variables are expressed as mean AE SD or as median [interquartile range], and proportions were used for categorical variables. From March 31 to May 10, 2020, 508 adult patients with COVID-19 infection were admitted to the hospital. Among them, 55 patients (11%, 51 males) required ICU admission and were