The Effect of Discontinuation of Angiotensin-II Receptor Blocker on Therapeutic Effect of Synthetic Erythropoietin on Anemia Modification in Hemodialysis Patients (original) (raw)
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Research in Sport Medicine and Technology, 2019
The aim of this study was comparing professional futsal practice sessions with and without blood flow restriction on angiogenesis and angiostatin stimulation in active young men. Among physical education students, 12 volunteer selected and randomly divided into two groups of exercise with and without blood restriction. All of the subjects did the 3 vs. 3 professional futsal practice in 6 repetition of two minutes. One minute determined as resting time between the repetitions. In exercise group with blood restriction, a cuff on the thighs with pressure of 140 Mm Hg were applied. The blood samples were collected before and after the exercise sessions to determine the ratio and values of VEGF and endostatin concentration. Elisa method was used to measure the variables. To determine within and between group differences, Paired T test and Independent T test were used respectively at significance level of 0.05. The results showed no significant differences for the measured variables between the groups. However, VEGF significantly decreased in the two groups after exercise session (P=0.002). The ratio of VEGF to endostatin significantly increased in exercise with blood flow restriction group (P=0.002), but not in the Exercise group (P=0.006). Interestingly, the endostatin concentration increased significantly after the trial (BFR: P=0.003, NONBFR: P=0.005). Blood lactate was significantly higher in exercise group with blood restriction(P=0.003). In conclusion, a professional futsal practice session can decrease blood level of VEGF and increase its endostatin.
Health Research Journal, 2016
Introduction: Because of widespread use of peripheral venous catheters its complications is also common. One of the most common complications, is inflammation of the vein or thrombophlebitis. The role of the various factors on its incidence have been identified, but the role of some personal factors have not been studied. Methods: A total of 232 patients who had venous catheter for therapeutic purposes, in a twoweek period were evaluated for incidence of thrombophlebitis through constant observation and the relationship between incidence of this complication by gender, occupation and education of patient and so education as well as experience of nurses were analyzed. Final analysis was performed by Chi-square and Mann-Whitney and also logistic regression. Results: A total of 55 patients (23.6%) of these subjects (33 males and 22 females) were suffering from thrombophlebitis. It were not observed any relation between patient gender and job and so work experience of nurse and the incidence of thrombophlebitis. But the higher education of nurse and lower education of patients reduced the incidence of thrombophlebitis. Conclusion: It seems that in addition to physical and underlying disease, other factors such as level of education also have an impact on the incidence of thrombophlebitis.
2017
1M.Sc., Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, Bojnourd Branch of Islamic Azad University, Bojnourd, Iran 2Associate Professor, Department of Exercise Physiology, Faculty of Sports Sciences, Ferdowsi University of Mashhad, Mashhad, Iran 3Assistant Professor, Department of Sports Sciences, Toos Institute of Higher Education, Mashhad, Iran 4Ph.D. Candidate, Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, Bojnourd Branch of Islamic Azad University, Bojnourd, Iran
Iranian Journal of Diabetes and Metabolism, 2019
Background: Diabetic cardiomyopathy is the first cause of death in diabetic patients and angiogenesis is the most important mechanism for the recovery of heart blood flow in physiologic and pathologic conditions. The purpose of this study was to compare the effect of eight weeks of moderate continuous and sever interval training on heart angiogenesis in Wistar male diabetic rats. Methods: 32 Wistar rats were randomly assigned into 4 groups: healthy non-exercised, diabetic no exercise, diabetic + moderate continuation and diabetic + severe interval exercises. Two types of exercises were calibrated and the exercise intensity was determined based on the maximum oxygen consumption and 5 days a week. The pro-angiogenic (VEGF, MMP2, TGFβ1) and anti-angiogenic (TIMP2) agents of the left ventricle of the heart were taken from the rat after 48 hours of the last training session. Western blot method was used to evaluate the synthesis of proteins involved in angiogenic route. Data were measure...
North Khorasan University of Medical Sciences, 2024
Introduction: Chronic renal failure directly and indirectly changes the quality of life of the patients. To maintain the quality of life, self-efficacy plays an effective role. Investigation of the relationship among stress, quality of life, and self-efficacy can help nurses to apply suitable ways to improve the quality of life of patients. Therefore, the present study aimed to determine the severity of stress and its relationship with self efficacy and quality of life in hemodialysis patients in Imam Khomeini Hospital in Shirvan, Iran. Method: This cross-sectional correlational study was carried out on 77 hemodialysis patients in 2022. The research tools included demographic characteristics and quality of life questionnaire, alongside human stress and general self-efficacy measurements. The collected data were analyzed in SPSS software (version 19). Results: Mean age and weight of the participants were 56.5 ± 14.73 years and 66.48 ± 17.15 Kg, respectively. Moreover, 59.7% of the patients were male and 41.6% of them performed dialysis for 1-3 years. There was a significant relationship between the mean stress score and score of some dimensions of quality of life (P<0.05). However, there was no significant relationship between the mean score of stress and self-efficacy. In addition, there was no significant relationship between the average of self-efficacy score and some dimensions of quality of life (P≥0.05). Conclusion: According to the results, the quality of life of hemodialysis patients improves by reducing the stress intensity. Meanwhile, people who have a higher level of self efficacy experience less stress. Therefore, the effort of the treatment staff is to identify the aggravating factors and use suitable interventions to reduce them with the aim of improving the quality of life of patients.
2020
Background and Aim Diabetes mellitus is one of the leading causes of death, and its prevalence is increasing annually because of the change in lifestyle. Increased blood glucose level and dyslipidemia are the major symptoms of this metabolic disease. Currently, the main and effective treatment for diabetes is the use of medication such as insulin. Its control by using herbal products has received a lot of attention in the world. The aim of this study is to evaluate the effects of bioflora (a probiotic supplement) and aqueous extract of cinnamon in improvement of blood glucose level, dyslipidemia, and reduction of cardiovascular diseases in diabetic rats. Methods & Materials Thirty-five male Wistar rats were prepared and randomly divided into five groups of negative control, positive control, probiotic (treated with bioflora 3.2×108 CFUs/day for 30 days), cinnamon (treated with 200 mg/kg of cinnamon aqueous extract for 30 days), and probiotic + cinnamon. Diabetes was induced by intra-peritoneally injection of streptozotocin. The rats' weight, blood glucose level, lipid profile, high sensitivity C-Reactive Protein (hs-CRP) and Atherogenic Index (AI) were measured at the end of experiment to predict the risk of cardiovascular diseases. Ethical Considerations This study ethically approved in Research Centre of Islamic Azad University of Arak (Code: IR.IAU.ARAKREC1397.005). All interventions performed in accordance with the Guide for Care and Use of Laboratory Animals prepared by the Institute of Laboratory Animal Resources. Results Induction of diabetes caused severe weight lost in rats, but the weight loss was lower in groups treated with probiotic. The blood glucose level in probiotic + cinnamon group was significantly reduced. Bioflora reduced triglyceride, cholesterol, and Low-Density Lipoprotein Cholesterol (LDL-C) levels, while cinnamon extract significantly reduced triglyceride and LDL-C levels compared to the positive control group. AI and hs-CRP values were reduced in the probiotic group compared to control groups. There was no synergistic effect by combined use of bioflora and cinnamon extract. Conclusion Bioflora effectively prevented dyslipidemia by improving intestinal microbiota, lowering blood glucose level, and improving lipid profile and, therefore, reduced the risk of cardiovascular diseases.
Quarterly of the Horizon of Medical Sciences
Aims Physical activity is usually accompanied by free radicals’ production and oxidative stress. Moreover, to prevent adverse effects, coaches and athletes have to use proper supplementation. Therefore, the present study aimed to investigate the effect of short-term coenzyme Q10 supplementation on malondialdehyde and serum catalase enzyme activity following moderate and severe acute resistance training in inactive female students. Methods & Materials In total, 27 female students were randomly divided into three groups; the groups were homogeneous and equal (two groups of resistance training and one control group). The experimental groups were subjected to moderate-intensity acute (70% 1RM) acute and severe acute activity (85% 1RM) and supplemented with coenzyme Q10 (30 mg /d). CAT and MDA were measured in ELISA using a human kit. Findings Moderate and severe acute resistance activities did not alter MDA and catalytic activity (P>0.05); however, after 2 weeks of coenzyme Q10 suppl...
journal of ilam university of medical sciences, 2021
Nonparametric regression can usually be used when the distribution of the dependent variable does not follow the property of normality. In this study, due to the nature of the variables, a bivariate Capula regression model was used to identify the factors affecting the liver enzymes (ALT and AST) and the relationship between these enzymes. This type of regression is suitable when the response variables have a relatively high degree of skewness and interdependence. Material & Methods: In this cross-sectional study, a sample of 2000 participants in the Shahrekord cohort study were randomly selected. To achieve the Capula regression model, the inverse Gaussian margin distribution and the Gumble joint function were selected according to the Akaike criterion. Gamlss, Copula, and Ggrm statistical packages were used in the R software. (Ethic code: 3316) Findings: According to the findings, some variables were identified as effective factors on the concentration of ALT and AST enzymes through marginal distribution parameters and Capula function. Blood urea, triglyceride, GGT, ALP, and BMI had a nonlinear and significant effect on the mean concentration of the ALT enzyme. The BMI, GGT, ALP, LDL, and HDL (nonlinearly), as well as blood urea (linearly), had a significant effect on the mean concentration of AST enzyme. Finally, the variables of BMI, triglycerides, GGT, and ALP affect the relationship between the concentration levels of the liver enzymes (ALT and AST). Discussion & Conclusion: Using this model, in addition to identifying the effective factors, it is possible to distinguish between linear and nonlinear relationships between independent and dependent variables.
2018
2 (1 ،) 55-43 بهار 1331 IranJPP Iranian Journal of Physiology and Pharmacology ٖایشا فبسٔبوِٛٛطی ٚ فیضیِٛٛطی ّٝٔد (خّذ 2 ٜؿٕبس 1 ثٟبس 1397) 43 تأسیس 1341 بررسی اثر متفورمین بر در هیدروژن پراکسید از ناشی آپوپتوز سلول های اندوتلیال جدا انسانی شده از سیاهرگ بند ناف ٜصاد ٗأی ٜآصاد ٖوشٔب ،ٖوشٔب پضؿىی ّْٛػ ٜدا٘ـٍب ،داسٚػبصی ٜدا٘ـىذ ،ؿٙبػی ٓػ ٚ فبسٔبوِٛٛطی ٌٜٚش ٔشوض تحمیمبت ،فبسٔبػیٛتیىغ ٜپظٚٞـىذ ٘ٛسٚفبسٔبو ،ِٛٛطی ٜدا٘ـٍب ّْٛػ پضؿىی ،ٖوشٔب ٖوشٔب :دسیبفت 16 ؿٟشیٛس 95 :پزیشؽ 3 آرس 95 پژوهشی مقاله Abstract Introduction: Metformin is an anti-diabetic drug, which may be a novel therapeutic option for treatment of atherosclerosis. The current study evaluates protective capacity of metformin in hydrogen peroxide (H 2 O 2)-induced oxidative stress in human umbilical vein endothelial cells (HUVECs). Methods: Endothelial cells were treated with metformin for 24 h. Then they were tr...