Pediatric Renal Transplantation: Comparative Study With Renal Transplantation in the Adult Population (original) (raw)

2005, Transplantation Proceedings

Purpose. To retrospectively review our experience with pediatric renal transplantation and to compare the results with the adult population. Patients and methods. Between January 1981 and August 2003, 74 renal transplants were performed in patients Յ18 years at the time of the transplant-the pediatric group versus 1153 patients in the adult group. We analyzed various risk factors for actuarial kidney graft and patient survivals using the Kaplan-Meier method. Results. Median ages were 13.8 Ϯ 3.5 and 42.6 Ϯ 2.4 years, respectively. There was no statistically significant difference in the human leukocyte antigen matching or immunosuppression. There was, however, a younger donor age and shorter ischemia time in the pediatric group. Overall, kidney transplant survival rates for patients Յ18 years at 1, 2, 5, and 10 years were 94.4%, 91.3%, 70.6%, and 58.2%, respectively, with no significant difference for patients older than 18 (91.2%, 89.3%, 78.8%, 60.5%, P ϭ .4325). There was a significantly decreased graft survival in the adult group at 10 years when the donor age was over 60 years and when the ischemia time was Ն20 hours. The incidence of delayed graft function and the creatinine levels of functioning grafts did not differ between the two groups. During the follow-up, acute rejections were more frequent in the younger group. Patient survival in the pediatric group at 1, 2, 5, and 10 years was 98.6%, 98.8%, 98.6%, and 90.3%, respectively, significantly lower in the adult group (95.3%, 94.0%, 87.9%, 76.8%, P Ͻ .02).