3D printing of PEEK and its composite to increase biointerfaces as a biomedical material- A review (original) (raw)

Harnessing the Potential of Natural Composites in Biomedical 3D Printing

Materials, 2024

Natural composites are emerging as promising alternative materials for 3D printing in biomedical applications due to their biocompatibility, sustainability, and unique mechanical properties. The use of natural composites offers several advantages, including reduced environmental impact, enhanced biodegradability, and improved tissue compatibility. These materials can be processed into filaments or resins suitable for various 3D printing techniques, such as fused deposition modeling (FDM). Natural composites also exhibit inherent antibacterial properties, making them particularly suitable for applications in tissue engineering, drug delivery systems, and biomedical implants. This review explores the potential of utilizing natural composites in additive manu-facturing for biomedical purposes, discussing the historical development of 3D printing tech-niques, the types of manufacturing methods, and the optimization of material compatibility, printability, and mechanical properties to fully utilize the potential of using natural fibers in 3D printing for biomedical applications.

3D printing of biomaterials

MRS Bulletin, 2015

Three-dimensional (3D) printing represents the direct fabrication of parts layer-by-layer, guided by digital information from a computer-aided design fi le without any part-specifi c tooling. Over the past three decades, a variety of 3D printing technologies have evolved that have transformed the idea of direct printing of parts for numerous applications. Threedimensional printing technology offers signifi cant advantages for biomedical devices and tissue engineering due to its ability to manufacture low-volume or one-of-a-kind parts on-demand based on patient-specifi c needs, at no additional cost for different designs that can vary from patient to patient, while also offering fl exibility in the starting materials. However, many concerns remain for widespread applications of 3D-printed biomaterials, including regulatory issues, a sterile environment for part fabrication, and the achievement of target material properties with the desired architecture. This article offers a broad overview of the fi eld of 3D-printed biomaterials along with a few specifi c applications to assist the reader in obtaining an understanding of the current state of the art and to encourage future scientifi c and technical contributions toward expanding the frontiers of 3D-printed biomaterials.

Various methods of 3D and Bio-printing

Stomatoloski glasnik Srbije

Summary There is growing need for synthetic tissue replacement materials designed in a way that mimic complex structure of tissues and organs. Among various methods for fabrication of implants (scaffolds), 3D printing is very powerful technique because it enables creation of scaffolds with complex internal structures and high resolution, based on medical data sets. This method allows fabrication of scaffolds with desired macro- and micro-porosity and fully interconnected pore network. Rapid development of 3D printing technologies has enabled various applications from the creation of anatomical training models for complex surgical procedures to the printing of tissue engineering constructs. The aim of current investigations was to develop compatible printers and materials (bioinks) to obtain biomimetic scaffolds, which allow printing of living cells without significant loss of cell viability. The advanced level of such printing assumes “in situ” printing, i.e. printing cells and biom...

Parameters Influencing the Outcome of Additive Manufacturing of Tiny Medical Devices Based on PEEK

Materials, 2020

In this review, we discuss the parameters of fused deposition modeling (FDM) technology used in finished parts made from polyether ether ketone (PEEK) and also the possibility of printing small PEEK parts. The published articles reporting on 3D printed PEEK implants were obtained using PubMed and search engines such as Google Scholar including references cited therein. The results indicate that although many have been experiments conducted on PEEK 3D printing, the consensus on a suitable printing parameter combination has not been reached and optimized parameters for printing worth pursuing. The printing of reproducible tiny-sized PEEK parts with high accuracy has proved to be possible in our experiments. Understanding the relationships among material properties, design parameters, and the ultimate performance of finished objects will be the basis for further improvement of the quality of 3D printed medical devices based on PEEK and to expand the polymers applications.

3D printing technology as innovative solutions for biomedical applications

Drug Discovery Today, 2021

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Recent Developments in 3D Bio-Printing and Its Biomedical Applications

Pharmaceutics

The fast-developing field of 3D bio-printing has been extensively used to improve the usability and performance of scaffolds filled with cells. Over the last few decades, a variety of tissues and organs including skin, blood vessels, and hearts, etc., have all been produced in large quantities via 3D bio-printing. These tissues and organs are not only able to serve as building blocks for the ultimate goal of repair and regeneration, but they can also be utilized as in vitro models for pharmacokinetics, drug screening, and other purposes. To further 3D-printing uses in tissue engineering, research on novel, suitable biomaterials with quick cross-linking capabilities is a prerequisite. A wider variety of acceptable 3D-printed materials are still needed, as well as better printing resolution (particularly at the nanoscale range), speed, and biomaterial compatibility. The aim of this study is to provide expertise in the most prevalent and new biomaterials used in 3D bio-printing as well...

Application of 3D printing for engineering and bio-medicals: recent trends and development

https://doi.org/10.1007/s12008-022-01145-z, 2022

Manufacturing, industrial design, decorations, footwear, design, architecture, engineering and construction, car, aviation, dentistry and clinical enterprises, education, geographic data frameworks, structural designing, and a variety of other fields have all seen 3D printing as beneficial. In every area of application, additive manufacturing has been seen as a speedy and cost-effective solution. The applications of 3D printing are rapidly developing, and it is quickly becoming a genuinely remarkable breakthrough worth paying close attention to. In this article, we'll look at how 3D printing works, as well as existing and prospective applications in engineering and biomedicine. Scarcity of organ transplant recipients is a serious clinical concern all around the globe. Older procedures had a number of drawbacks, including complications, future injuries, and a scarcity of donors. Tissue engineering scaffolds, cell healing, and direct tissue printing are all potential for overcoming these limitations using 3D printing technology. This article provides an overview of 3D printing advancements, materials, applications, advantages, limitations, challenges, financial considerations, and 3D metal printing applications. An introduction to biomedical materials, a discussion of material-related 3D printing challenges, and a discussion of the future potential uses for medical applications has been discussed in present article.

Applications of 3D-Printed PEEK via Fused Filament Fabrication: A Systematic Review

Polymers

Polyether ether ketone (PEEK) is an organic polymer that has excellent mechanical, chemical properties and can be additively manufactured (3D-printed) with ease. The use of 3D-printed PEEK has been growing in many fields. This article systematically reviews the current status of 3D-printed PEEK that has been used in various areas, including medical, chemical, aerospace, and electronics. A search of the use of 3D-printed PEEK articles published until September 2021 in various fields was performed using various databases. After reviewing the articles, and those which matched the inclusion criteria set for this systematic review, we found that the printing of PEEK is mainly performed by fused filament fabrication (FFF) or fused deposition modeling (FDM) printers. Based on the results of this systematic review, it was concluded that PEEK is a versatile material, and 3D-printed PEEK is finding applications in numerous industries. However, most of the applications are still in the researc...