Amino Acid Phosphoramidate Nucleotides as Alternative Substrates (original) (raw)
Synthesis of nucleoside 5′-O-α,β-methylene-β-triphosphates and evaluation of their potency towards inhibition of HIV-1 reverse transcriptase
Keykavous Parang
Organic & Biomolecular Chemistry, 2010
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Selective excision of chain-terminating nucleotides by HIV-1 reverse transcriptase with phosphonoformate as substrate
A. Rouzaut
2006
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3-Phosphono-l-alanine as pyrophosphate mimic for DNA synthesis using HIV-1 reverse transcriptase
Eveline Lescrinier
Org. Biomol. Chem., 2011
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2'-Deoxynucleoside 5'-triphosphates modified at alpha-, beta- and gamma- phosphates as substrates for DNA polymerases
Alexander Skoblov
Nucleic Acids Research, 1998
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δ-Di-carboxybutyl phosphoramidate of 2′-deoxycytidine-5′-monophosphate as substrate for DNA polymerization by HIV-1 reverse transcriptase
Francois Morvan
Bioorganic & Medicinal Chemistry, 2009
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Polymerase-catalyzed synthesis of DNA from phosphoramidate conjugates of deoxynucleotides and amino acids
Montserrat TERRAZAS
Nucleic acids …, 2007
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Synthesis and substrate properties towards HIV-1 reverse transcriptase of new diphosphate analogues of 9-[(2-phosphonomethoxy)ethyl]adenine
Stéphane Priet
Antiviral Chemistry and Chemotherapy
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Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase Inhibit Phosphorolysis and Resensitize the 3′-Azido-3′-deoxythymidine (AZT)-resistant Polymerase to AZT-5′-triphosphate
Alberto Pérez-mediavilla
Journal of Biological Chemistry, 2003
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4'-Acylated thymidine 5'-triphosphates: a tool to increase selectivity towards HIV-1 reverse transcriptase
Mario Amacker
Nucleic Acids Research, 1998
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Nucleoside analogues previously found to be inactive against HIV may be activated by simple chemical phosphorylation
caleb nickson
Febs Letters, 1993
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Modified nucleoside 5'-triphosphates containing 2',3'-fused threemembered rings as substrates for different DNA polymerases
Marina Kukhanova
FEBS Letters, 1993
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Nucleotide modification at the -phosphate leads to the improved fidelity of HIV-1 reverse transcriptase
Richard Willson
Nucleic Acids Research, 2005
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Template. Phosphorothioate oligonucleotides duplexes as inhibitors of HIV-1 reverse transcriptase
R. Goody
Biochemical and Biophysical Research Communications, 1992
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Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides
Giovanni Maga
Chemistry & Biology, 1999
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Decomposition Pathways and in Vitro HIV Inhibitory Effects of IsoddA Pronucleotides: Toward a Rational Approach for Intracellular Delivery of Nucleoside 5‘-Monophosphates
Loredana Cappellacci, Mario Grifantini
Journal of Medicinal Chemistry, 1996
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Conformational states of HIV-1 reverse transcriptase for nucleotide incorporation vs. pyrophosphorolysis - binding of foscarnet
Kalyan Das
ACS chemical biology, 2016
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Interaction of 2'-deoxyguanosine triphosphate analogue inhibitors of HIV reverse transcriptase with human mitochondrial DNA polymerase g
Raymond Schinazi
Antiviral chemistry & …, 2007
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Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones
John Beutler
Nucleic Acids Research, 2005
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Selective action of 4'-azidothymidine triphosphate on reverse transcriptase of human immunodeficiency virus type 1 and human DNA polymerases .alpha. and .beta
chinh bach
Biochemistry, 1993
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Solid-phase synthesis of 5′-O-β,γ-methylenetriphosphate derivatives of nucleosides and evaluation of their inhibitory activity against HIV-1 reverse transcriptase
Keykavous Parang
Tetrahedron Letters, 2010
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Nonnucleoside inhibitors of HIV-1 reverse transcriptase inhibit phosphorolysis and resensitize the 3 ’-azido-3 ’-deoxythymidine ( AZT )-resistant polymerase to AZTTP
Alberto Pérez-mediavilla
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Reactivity of Amino Acid Nucleoside Phosphoramidates: A Mechanistic Quantum Chemical Study
Arnout Ceulemans
The Journal of Physical Chemistry A, 2011
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Cellular Phosphorylation of Anti-HIV Nucleosides
Ricardo M. Biondi
Journal of Biological Chemistry, 1996
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Enhancing the catalytic repertoire of nucleic acids: a systematic study of linker length and rigidity
Mark Dickman
Nucleic acids …, 2001
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3'-Azido-3'-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase
Thomas Spector
Antimicrobial Agents and Chemotherapy, 1987
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8-Modified-2′-Deoxyadenosine Analogues Induce Delayed Polymerization Arrest during HIV-1 Reverse Transcription
Roland Marquet, G. Bec, Alain Burger
PLoS ONE, 2011
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Expanding the repertoire of DNA polymerase substrates: template-instructed incorporation of non-nucleoside triphosphate analogues by DNA polymerases and
Giovanni Maga
Nucleic Acids Research, 2006
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Synthesis and Properties of Aminopropyl Nucleic Acids
Roger Busson, Arthur Van Aerschot
ChemBioChem, 2005
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Examining Interactions of HIV-1 Reverse Transcriptase with Single-stranded Template Nucleotides by Nucleoside Analog Interference
Stuart Le Grice
Journal of Biological Chemistry, 2006
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Anti-HIV activities and physicochemical properties of phosphorothioate analogues complementary to HIV sequences
HIDEKI NAKASHIMA
Bioorganic & Medicinal Chemistry Letters, 1993
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DNA synthesis primed by mononucleotides (de novo synthesis) catalyzed by HIV-1 reverse transcriptase: tRNALys,3 activation
Olga Zakharova
FEBS Letters, 1995
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The Enzyme‐Free Release of Nucleotides from Phosphoramidates Depends Strongly on the Amino Acid
Pradeep Pallan
Angewandte Chemie International Edition, 2020
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Efficient Inhibition of Transcription Elongationin vitroby Oligonucleotide Phosphoramidates Targeted to Proviral HIV DNA
Sergei Gryaznov
Journal of Molecular Biology, 1996
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Influence of the Nucleobase and Anchimeric Assistance of the Carboxyl Acid Groups in the Hydrolysis of Amino Acid Nucleoside Phosphoramidates
Arnout Ceulemans
Chemistry - A European Journal, 2011
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