Congenital granular cell lesion: A rare tumor of new born (original) (raw)

Congenital granular cell tumor (congenital epulis): a lesion of multidisciplinary interest

Medicina oral, patología oral y cirugía bucal, 2007

Congenital granular cell tumor (CGCT), or congenital epulis, is a very uncommon benign soft tissue lesion that usually arises from the alveolar mucosa of neonates and may cause respiratory and feeding problems. We report a case of a 3-day-old female newborn, who presented an intraoral tumor mass which was protruding from her mouth, and compromising feeding. Under general anesthesia, the lesion was completely removed and the patient had an uneventful postoperative course. Clinical features and treatment approaches are presented and discussed, emphasizing the necessity of a multidisciplinary approach in such cases.

Congenital Granular Cell Tumor of a Newborn: A Case Report

Indian Journal of Neonatal Medicine and Research, 2016

Congenital Granular Cell Tumour (CGCT) is a rare benign soft tissue tumour of newborn, different from adult GCT. The tumour has a strong predilection for the maxillary alveolar ridge with a female preponderance. Here we report an unusual case of congenital granular cell epulis in the mouth of a 2 hour old female newborn. She had a round, soft, pedunculated mass measuring (2x 2x1) cm. which was causing feeding difficulty. This case was reported as congenital granular cell epulis. We are presenting this case because of its rare nature and uncommon presentation at this age.

Congenital granular cell epulis—a case report

Oral and Maxillofacial Surgery Cases, 2015

Congenital granular cell epulis (CGCE) is an uncommon benign lesion found in newborns. It has predominance for females with an 8:1 ratio in relation to males and is exclusively encountered in the oral cavity. The most affected oral site is located around the canine/incisor region of the maxillary alveolar ridge, where the lesion arises from the soft tissue as a solitary pedunculated mass. CGCE's histogenesis remains obscure and controversial. We present a rare case of 2 separate CGCE lesions adjacent to each other measuring 23 Â 18 Â 10 and 15 Â 10 mm, positioned facially on the right maxillary alveolar process. The patient, a 2-day-old female newborn, did not experience any serious difficulty regarding breathing or deglutition. Complete surgical excision was the treatment of choice in this case, and the procedure was performed under both general and local anesthesia. Histologic and immunohistochemical analysis confirmed the diagnosis of CGCE. The patient showed satisfactory postoperative healing and excellent health at both the 10-day recall appointment and the 6-month follow-up.

Congenital granular cell epulis: a case report with immunohistochemistry

گۆڤاری ههولێر بۆزانستی پزیشکی ددان, 2021

Congenital granular cell epulis is a rare benign tumor of soft tissue in newborns. In most cases it arises from the anterior part of the maxillary alveolar ridge and is ten times more prevalent in females than males. We present a case report of a 2-month-old female infant, who presented with a mass on the gingival mucosa. The lesion was completely removed by simple excision. A final diagnosis of a congenital granular cell tumor was made by histologic and immunohistochemical examination.

Multiple Congenital Granular Cell Tumor in a Neonate - A Rare Case

APSP Journal of Case Reports

Congenital granular cell tumor (CGCT) is an uncommon congenital benign epulis in neonates. A preliminary diagnosis is usually put forth clinically but may be confused with other anomalies. Herein, we report an unusual case of intra oral congenital granular cell tumor in a 4-day-old female newborn. The tumor was excised completely. At 3-month follow-up, the baby is doing fine without any recurrence.

A case report of a huge congenital granular cell epulis operated under local anesthesia

The Pan African medical journal, 2012

Congenital granular cell epulis (CGCE) is a very rare benign soft tissue lesion of the neonate, it most frequently located on the anterior maxillary alveolar ridge. It has a female predilection. It is a tumor with no tendency to recur after excision. The exact histogenesis of this tumor remains unresolved and it may be hamartomata.

Congenital granular cell lesion: a case report

Revista de Cirurgia …, 2010

The congenital granular cell lesion is a rare disease that affects newborns. We present a case of a patient with nodular lesions that were located on the anterior part of the maxillary alveolar. The surgical resection of the one lesion and its histological and immunohistochemical study were made.

Congenital granular cell epulis -Unraveling the histogenesis

Journal of Oral Medicine, Oral Surgery, Oral Pathology and Oral Radiology, 2023

Congenital Granular cell epulis is a rare benign tumor of the newborn. It also known as granular cell tumor of the newborn or Neumann's tumor. It originates exclusively on the alveolar ridge, most commonly seen in maxillary anterior region, typically seen as a mass protruding out of the mouth, which may interfere with respiration or feeding. Despite its striking appearance, the lesion is ultimately benign. However, immediate surgical treatment is required if there is a risk of airway obstruction or feeding difficulties. Here, two cases were reported to reveal the histological findings and reassess the immunohistochemical characteristics that may hint towards the histogenesis of the congenital epulis. Histopathology of both masses composed of diffuse sheets and clusters of polygonal cells containing small round to oval nuclei and abundant coarsely granular cytoplasm. The immunoreactivity of the granular cell was examined by immunohistochemical markers such as S100 protein, CD68, CD1a and Neuron specific enolase (NSE). In the present case tumour cells were positive for NSE and CD68 and negative for S100 and CD1a. Although the exact nature of its histogenesis still remains a mystery. Keywords: Congenital epulis, Granular cell, Histogenesis, Neumann's tumor.