Formulation of Ondansetron HCl Matrix Tablets with Microenvironmental pH Modifier for Improved Dissolution and Bioavailability under Hypochlorhydria (original) (raw)
2016, Asian Journal of Pharmaceutics
Background: Ondansetron hydrochloride is a serotonin sub type-3 (5-hydroxytryptamine-3) receptor antagonist. It is a widely used drug for the treatment of post-operative nausea and vomiting (PONV) and chemotherapy-induced nausea and vomiting. The recommended oral dose regimen of ondansetron hydrochloride is 8 mg, three times a day up to 1 week and it is having a short biological half-life, approximately 3-5 h. Therefore, there is a need to once daily controlled release drug delivery systems to extend its therapeutic action entire the day. Aim: The main object of the present work deals with the development of pH-independent controlled release tablets of ondansetron HCl using pH modulating technique. Materials and Methods: Ondansetron HCl is a weakly basic drug belongs to BCS Class-II and it is showing distinct pH-dependent solubility. The solubility exhibits high solubility at low pH (pH 1.2) at 37°C (23.3 mg/ml); however, it exhibits poor solubility at higher pH (6.8 pH phosphate bu...
Sign up for access to the world's latest research.
checkGet notified about relevant papers
checkSave papers to use in your research
checkJoin the discussion with peers
checkTrack your impact
Loading Preview
Sorry, preview is currently unavailable. You can download the paper by clicking the button above.