Formulation of Ondansetron HCl Matrix Tablets with Microenvironmental pH Modifier for Improved Dissolution and Bioavailability under Hypochlorhydria (original) (raw)

Background: Ondansetron hydrochloride is a serotonin sub type-3 (5-hydroxytryptamine-3) receptor antagonist. It is a widely used drug for the treatment of post-operative nausea and vomiting (PONV) and chemotherapy-induced nausea and vomiting. The recommended oral dose regimen of ondansetron hydrochloride is 8 mg, three times a day up to 1 week and it is having a short biological half-life, approximately 3-5 h. Therefore, there is a need to once daily controlled release drug delivery systems to extend its therapeutic action entire the day. Aim: The main object of the present work deals with the development of pH-independent controlled release tablets of ondansetron HCl using pH modulating technique. Materials and Methods: Ondansetron HCl is a weakly basic drug belongs to BCS Class-II and it is showing distinct pH-dependent solubility. The solubility exhibits high solubility at low pH (pH 1.2) at 37°C (23.3 mg/ml); however, it exhibits poor solubility at higher pH (6.8 pH phosphate bu...