Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium (original) (raw)

Abstract

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Genetic determinants of heel bone properties were investigated through a meta-analysis of genome-wide association studies. Significant associations were found with nine single nucleotide polymorphisms (SNPs), including a novel locus near TMEM135 linked to osteoblastogenesis, which may enhance understanding of osteoporosis. The study indicates that both quantitative ultrasound measures and BMD share common genetic factors, providing insights into fracture risk assessment.

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