Solitary amyloid tumor of the tongue base (original) (raw)
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Rare amyloidoma of the tongue base: A case report and review of the literature
Molecular and Clinical Oncology
Localized amyloidosis is a rare condition characterized by the deposition of misfolding protein in a tissue, without other systemic manifestations. Only a small number of cases of localized amyloidosis of the tongue have been reported to date, in contrast to systemic amyloidosis, in which localization on the tongue is common. This study presents a rare case of localized amyloidosis of the tongue (amyloidoma) and provides a summary of the known literature of localized amyloidosis. This study describes the case of a 36-year-old female who presented with a swelling of the tongue base. The diagnosis of amyloidoma was made based on the findings of the physical examination, head and neck MRI findings and the histopathological examination with Congo red stain under polarized light. The histopathological diagnosis was as follows: Localized lambda light-chain amyloidosis. A thorough physical examination was performed by the ENT and Hematology/Oncology departments, without revealing signs of systemic disease. A series of hematological and imaging tests were also performed to verify that there was no sign of systemic involvement. The patient declined surgical excision and the 2-year follow-up did not reveal any changes in tumor dimension. Although the etiology of localized amyloidosis is yet not clear, the prolonged reaction of tissue plasma cells to environmental antigens may be a causative factor for the initiation of the neoplastic process.
Primary systemic amyloidosis of tongue with chondroid metaplasia
Journal of Oral and Maxillofacial Pathology, 2013
Amyloid is a pathologic proteinaceous substance deposited between cells in various tissues in a variety of clinical conditions. We report a case of amyloidosis of tongue with extensive chondroid metaplasia diagnosed on incisional biopsy in a multiple myeloma patient, who underwent autologous peripheral blood stem cell transplant for the same in 2010 and now presented with disease relapse after 2 years.
Amyloid deposition in the tongue: clinical and histopathological profile
Anticancer research, 2010
Oral amyloidosis is a rare and debilitating disease that, whether primary or secondary, may severely impact the quality of a patient's life. The study investigated the characteristics of amyloid deposition in the tongue from the clinical and histopathological profiles. Biopsy specimens were received from five patients: 2 female, 3 male. All biopsies were taken from the tongue, and all had amyloid deposition in the subepithelial connective tissue, conclusive for a diagnosis of amyloidosis. All patients showed macroglossia and difficulty in eating and impairment of speech. In three cases there was no evidence of systemic involvement or associated disease; these were characterized as localized amyloidosis of the tongue. The other two cases revealed multisystemic involvement. Histologically, the disease was diagnosed through specific staining with Congo red, which examined under polarized light revealed the amyloid deposits as apple-green birefringence. The findings show the tongue ...
Oral localized amyloidosis: a literary analisys and case report
Journal of Oral Diagnosis, 2022
Introduction: Amyloidosis is a condition related to aggregates of proteins in several organs of the body and can be systemic or localized. Amyloidosis localized in the oral cavity is extremely rare, being the tongue the more prevalent region. Objective: The aim of this present study is to describe a case of localized amyloidosis on the tongue and surgically removed. Methods: Also, a review of English-language literature of oral localized amyloidosis from 1946 to 2021 was performed. Results: A total of 52 cases of oral localized amyloidosis were found in the literature. The majority of the cases was observed in female patients (53,84%), with an average age of 55,4 years (range 9 to 90 years) and the tongue being the most common localization (49,12%). Conclusions: Amyloidosis is a rare condition with atypical sign and symptoms. The systemic involvement should be evaluated due to worse prognosis of this condition and the possibility of organs failures. There is no standard treatment for local amyloidosis, but surgical excision is indicated to reduce the functional prejudice and pain, in symptomatic cases.
Solitary Fibrous Tumor of the Dorsal Tongue Area
Indian Journal of Otolaryngology and Head & Neck Surgery, 2018
Solitary fibrous tumor (SFT) is a rare tumor occurring in pleura or extrapleural areas. The tongue is infrequently affected, in less than 25 published cases. A female patient, 35 years of age, noticed an oval mass in the posterior dorsal part of the tongue. The operated mass was nodule, 10 mm in size, sharply circumscribed, rather firm. The histology shows uniform CD34 positive spindle tumor cells. The diagnosis of benign SFT of the tongue was made.
Annals of Diagnostic Pathology, 2002
Solitary fibrous tumors are rare in extrapleural sites and extremely rare in the oral cavity. We report a case of a solitary fibrous tumor arising from the tongue of a 70-year-old woman. The tumor measured 1.6 cm in maximum diameter and consists of spindle-shaped cells distributed in a haphazard pattern. Immunohistochemical studies show strong positivity for CD34 and bcl-2, and weak positivity for desmin. Smooth muscle actin and S-100 protein are negative. Electron microscopy shows uniform neoplastic spindle cells with mesenchymal features. The differential diagnosis for spindle cell neoplasms in the tongue is discussed.
Localized Amyloidosis of the Neck: A Rare Case and Literature Review
Genes Review
Amyloidosis is the term used for a group of diseases characterized by extracellular deposition of fibrillar proteinaceous substance called amyloid, in a βpleated sheet conformation. Amyloidoma or amyloid tumor is a tumor-like localized deposit of amyloid encountered occasionally in association with multiple myeloma, various chronic inflammatory diseases and primary amyloidosis. Soft tissue amyloidoma is rare, and soft tissue amyloidoma without evidence of systemic amyloidosis is even rarer. We report a rare case of primary AL type localized amyloidoma with a clinicopathological review and particular attention to its head and neck manifestation.
Malignant solitary fibrous tumor of the tongue
American Journal of Otolaryngology, 2003
Solitary fibrous tumor is a generally benign spindle-cell neoplasm that has been predominantly described in the visceral pleura and other serosal sites and is extremely rare in the head and neck area. We report the first known case of malignant solitary fibrous tumor of the tongue in a 57-year-old female patient who experienced rapid growth of a longstanding right anterior tongue mass, with associated dysphagia and dysarthria. Magnetic resonance imaging was suggestive of a low-flow vascular malformation not requiring preoperative embolization. The patient underwent partial peroral glossectomy for the excision of the tumor. Final pathology, however, was consistent with solitary fibrous tumor, characterized as malignant by histopathologic criteria, and the patient was returned for re-excision of the close surgical margins. The patient has experienced symptomatic improvement, and she remains free of recurrence 12 months later. All reports of solitary fibrous tumors of the oral cavity and 3 reports of the tongue tumors described in the literature to date represent benign lesions. To our knowledge, this is the first report of a malignant solitary fibrous tumor of the tongue. Presentation, differential diagnosis, criteria for malignancy, treatment, and possible prognostic implications of this rare entity are discussed.
Unusual presentation of oral amyloidosis
Contemporary Clinical Dentistry, 2015
Amyloidosis is a rare disease of difficult diagnosis that occurs due accumulation of amyloid substance localized or systemic. The oral cavity is an unusual site and can be related to both localized and systemic forms and for that reason a full investigation is necessary to determine the extent of the disease. This study reports a case of a 58-year-old melanoderm male patient referred to the Department of Oral and Maxillofacial Surgery with white plaques on the tongue and multiple nodules in the region of the buccal mucosa and labial commissure, with 6 months of evolution and painful symptoms. An incisional biopsy was performed on both sites and histological examination indicated the presence of eosinophilic amorphous material within the connective tissue, positive for crystal violet staining, consistent with amyloidosis. At the present time, there is no consensus on the management of local amyloidosis. Surgical treatment of localized forms is indicated in some cases to reduce the functional prejudice. Moreover, follow-up is mandatory, both to manage recurrences and to monitor the possible evolution of the disease to the systemic form.