A Modified Method for the Synthesiss of Nitrofurazone (original) (raw)
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2011
Department of Chemistry, St. Stephen's College, University of Delhi, Delhi-110 007, India<br> E-mail : sv .eswaran@gmail.com<br> Department of Biology, University of Massachussets, Boston, MA, USA<br> Division of Agricultural Chemicals, Indian Agricultural Research Institute, New Delhi-110 012, India<br> Manuscript received 21 January 2010, revised 08 June 2010, accepted 16 <em>July</em> 2010 2,4-Dinitrophenylazide was subjected to 'Click' reaction thermally in the presence of phenyl acetylene and<br> copper sulphate, sodium ascorbate as catalysts. In this reaction instead of the desired 1-(4-nitrophenyl)-4-phenyl-1<em>H</em>-<br> 1,2,3-triazole, the formation of 5(6)-nitrobenzofuroxan was observed. The same re&ult was obtained when the reaction<br> was carried out in a household microwave oven in 45 s. 'Click' reaction on 4-nitrophenylazide led to the desired triazolcs.<br> Thus an intramole...