Synthesis and Characterization of Bioactive Sol – Gel Glass: A Preliminary Study (original) (raw)
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Biomatter
Bioactive glass is one of the widely used bone repair material due to its unique properties like osteoconductivity, osteoinductivity and biodegradability. In this study bioactive glass is prepared by the sol gel process and stabilized by a novel method that involves a solvent instead of the conventional calcinations process. This study represents the first attempt to use this method for the stabilization of bioactive glass. The bioactive glass stabilized by this ethanol washing process was characterized for its physicochemical and biomimetic property in comparison with similar composition of calcined bioactive glass. The compositional similarity of the two stabilized glass powders was confirmed by spectroscopic and thermogravimetric analysis. Other physicochemical characterizations together with the cell culture studies with L929 fibroblast cells and bone marrow mesenchymal stem cells proved that the stabilization was achieved with the retention of its inherent bioactive potential. ...
Synthesis and characterisation of sol gel derived bioactive glass for biomedical applications
Materials Letters, 2006
Bioactive glasses have been used successfully as bone-filling materials in orthopaedic and dental surgery, but their poor mechanical strength limits their applications in load-bearing positions. Approaches to strengthen materials decrease their bioactivity. In order to realize the optimal matching between mechanical and biological properties, the sol-gel-self propagating method is adopted to prepare gel-derived bioglass bulk: 58S in the system SiO 2 -CaO-P 2 O 5 . The obtained glass was analysed for its composition, crystalinity and morphology through FT-IR, Raman, XRD, STEM and X-ray microanalysis.
Characterization of Bioactive Glass Synthesized by Sol-Gel Process in Hot Water
2020
Bioactive glass 70SiO2-30CaO (mol.%) was successfully synthesized by modified sol–gel in hot water without using an acid catalyst. TG-DSC analysis showed that the amorphous glass could be synthesized by sintering the sample at 700 °C for three hours. The N2 adsorption/desorption and TEM investigations highlighted that the synthetic glass had a mesoporous structure, consisting of spherical particles with sizes in the range of 11–20 nm. The specific surface area, pore volume, and average pore diameter of synthetic glass were 150.13 m2/g, 0.37 cm3/g, and 11.84 nm, respectively. Moreover, synthetic bioactive glass presented interesting bioactivity and good biocompatibility after in vitro experiments in simulated body fluid (SBF) and in cellular medium.
Sol-gel derived bioactive glass ceramics for dental applications
Non-Metallic Biomaterials for Tooth Repair and Replacement, 2013
Sol-gel derived silica-based bioactive glasses and ceramics attain many advantages owing to silicon which has a benefi cial role in bone formation in vivo. They exhibit mesoporous architecture with interconnected pore structure and a high specifi c surface area that positively affects their bioactivity. Their compositions of up to 100 mol% SiO 2 in binary, ternary or quaternary systems, the potential for varying the microstructure in the same composition by controlling the chemical reactions and their ability to form scaffolds are some of the unique properties that distinguish them from their melt-derived counterparts. In the fi eld of dental restoration and regeneration, sol-gel silica-based bioactive composites have started to emerge in various applications including coatings, scaffolds and dental tissue regeneration.
Bioglass® and resulting crystalline materials synthesized via an acetic acid-assisted sol–gel route
Journal of Sol-Gel Science and Technology, 2017
In this study, we report on the synthesis of a bioactive glass powder with the original 45S5 composition (Bioglass ®) by means of an acetic acid-assisted sol-gel route. A glassy material was obtained after the gels underwent a thermal stabilization treatment at 600°C for 3 h. Above this temperature, the heat-treated gels crystallized partially, forming a sodium-calcium-silicate Na 2 CaSi 2 O 6 phase. Even after crystallization, this material showed in vitro bioactivity in simulated body fluid after 12 h, when the formation of hydroxycarbonate apatite on the material surface was identified by X-ray diffraction. Not surprisingly, microbiological assays revealed that these gel-derived materials appear to have an antibacterial effect against Pseudomonas aeruginosa (ATCC 27853)-a Gramnegative bacterium that is noted for its environmental survival versatility, ability to produce biofilm and resistance to some antibiotics. Thus, using common precursors that are widely available, relatively cheap, simple to use, and which result in gels with low stabilization temperature, it was possible to explore the versatility of sol-gel processing to obtain the golden standard 45S5 bioglass.
Bioactive glass nanoparticles obtained through sol–gel chemistry
Chemical Communications, 2013
The different routes of the sol-gel technique based on the 5 Stöber method enable preparation of the nanoparticles of SiO 2 -CaO glass with different average size diameter, narrow size distribution and good dispersible capability. The Eu 3+doped glass with luminescent properties can be also obtained.
Bioactive glass 58S prepared using an innovation sol-gel process
Processing and Application of Ceramics, 2019
A 58S bioglass with a composition in the ternary system 58SiO2-33CaO-9P2O5 (wt.%) was prepared by an innovation sol-gel process in which a small amount of ammonia was used to facilitate the condensation reactions within an acidic solution prepared by tetraethyl orthosilicate, triethyl phosphate and calcium nitrate tetrahydrate. The properties of synthetic glass were investigated by several techniques. The amorphous nature and high specific surface area (99.1m2/g) of the obtained glass were confirmed by using X-ray diffraction and low-temperature nitrogen adsorption techniques, respectively. In vitro experiments were performed by soaking glass samples in the simulated body fluid (SBF). The XRD patterns and SEM images confirmed the bioactivity of the synthesized bioglass by formation of a dense and visible hydroxyapatite layer on its surface after 2 days of in vitro assays. The ICP-OES data illustrated the ion exchange behaviours between the bioglass 58S and the SBF solution.
Hydrothermal assisted conventional sol-gel method for synthesis of bioactive glass 70S30Cы
2021
Bioactive glasses (Bioglasses) are widely synthesized by the conventional sol-gel method consisting of two main steps for sol and gel formation. However, the conversion from sol to gel requires a long time (5-7 days). In this study, the hydrothermal system was used to quickly synthesize the bioactive glass by reducing the conversion time from sol to gel. The hydrothermal assisted conventional sol-gel method was applied for synthesis of the bioactive glass 70SiO 2-30CaO (mol%) (noted as 70S30C). The synthetic glass was investigated by the physical-chemical techniques. The ''in vitro'' experiments in SBF (Simulated Body Fluid) solution was also performed to evaluate the bioactivity of synthetic material. The obtained results show that the bioactive glass 70S30C was successfully elaborated by using the hydrothermal assisted conventional sol-gel method. The consuming time was reduced compared to the conventional method. The physical-chemical characterization confirmed that the synthetic glass is amorphous material with mesoporous structure consisting of interconnected particles. The specific surface area, pore volume and average pore diameter of synthetic glass were 142.8 m 2 /g, 0.52 cm 3 /g, and 19.1 nm, respectively. Furthermore, synthetic bioactive glass exhibited interesting bioactivity when immersed in simulated body fluid (SBF) solution for 1 days and good biocompatibility when cultured in cellular media.
ACS omega, 2019
During the processes associated with glass corrosion, porous hydrated glass alteration layers typically form upon exposure to aqueous conditions for extended time periods. The impacts of the alteration layer on glass durability have not been agreed upon in the glass science community. In particular, the formation mechanisms of hydrated glass alteration layers are still largely unknown and require further investigation, but these layers often require months to years to develop and are often too thin to adequately characterize. Meanwhile, sol−gel-derived silicate gels are relatively easy to synthesize in bulk with custom compositions relevant to hydrated glass alteration layers. If alteration layers and synthetic silicate gels demonstrate physical and chemical properties that are sufficiently similar, synthetic silicate gels could be used as analogues for hydrated glass alteration layers in future studies. However, synthetic gels must first be prepared and evaluated before comparisons between glass alteration layers and synthetic silicate gels can be made. This work focuses entirely on the synthesis and observed physical properties of synthetic silicate gels. A future work will compare the characteristics of synthetic gels described in this work with altered waste glass formed in similar pH environments. In this study, synthetic gels were made with custom compositions at various pH values to evaluate the effect of pH on gel structure and morphology. Several other variables were examined also, such as composition, drying, and aging. Gels were produced by sequential additions of organometallic precursors in a single container. Gels were analyzed with several techniques including small-angle X-ray scattering, gas adsorption, and He pycnometry to determine the effects of the variables on physical properties. Results show that gels prepared at pH 3 consistently contained fewer primary particles with diameters larger than 7.2 nm and fewer pores with diameters larger than 30 nm compared to gels synthesized at pH 7 and 9. Composition was shown to have no discernable effect on primary particle and pore sizes at any pH.