Inotropic and chronotropic effects of 6-hydroxy-4-methylquinolin-2(1H)-one derivatives in isolated rat atria (original) (raw)

A Comparison of Three Phosphodiesterase Type III Inhibitors on Mechanical and Metabolic Function in Guinea Pig Isolated Hearts

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Comparison of cyclic nucleotide phosphodiesterase isoenzymes in rat and rabbit ventricular myocardium: positive inotropic and phosphodiesterase inhibitory effects of Org 30029, milrinone and rolipram

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ANTIARRHYTHMIC ACTIVITY OF SOME ISOQUINOLINE DERIVATIVES DETERMINED BY A RAPID SCREENING PROCEDURE IN THE MOUSE"2

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Pivotal effects of phosphodiesterase inhibitors on myocyte contractility and viability in normal and ischemic hearts

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The Inotropic Effect of the Active Metabolite of Levosimendan, OR-1896, Is Mediated through Inhibition of PDE3 in Rat Ventricular Myocardium

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Positive Inotropic Effect of the Inhibition of Cyclic GMP-Stimulated 3', 5'-Cyclic Nucleotide Phosphodiesterase (PDE~ 2) on Guinea Pig Left Atria in Eu-and …

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Current Status of Phosphodiesterase Inhibitors in the Treatment of Congestive Heart Failure

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Cardiovascular effects of a novel, potent and selective phosphodiesterase 5 inhibitor, DMPPO: in vitro and in vivo characterization

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(Imidazolylphenyl)pyrrol-2-one inhibitors of cardiac cAMP phosphodiesterase

Paul Erhardt

Journal of Medicinal Chemistry, 1993

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The effect duration of selective phosphodiesterase inhibitors in the guinea pig

Francesco Marchini

Life Sciences, 1998

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The effects of levosimendan and OR-1896 on isolated hearts, myocyte-sized preparations and phosphodiesterase enzymes of the guinea pig

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Potent Cardioprotective Effect of the 4-Anilinoquinazoline Derivative PD153035: Involvement of Mitochondrial KATP Channel Activation

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A quantitative comparison of functional and anti-ischaemic effects of the phosphodiesterase-inhibitors, amrinone, milrinone and levosimendan in rabbit isolated hearts

Alexis Rump

British Journal of Pharmacology, 1994

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The mechanism by which adenosine and cholinergic agents reduce contractility in rat myocardium. Correlation with cyclic adenosine monophosphate and receptor densities

Joel Linden

Circulation Research, 1985

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The Mechanism by Which Adenosine and Cholinergic Agents Reduce Contractility in Rat Myocardium

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Synthesis, Docking Studies, Pharmacological Activity and Toxicity of a Novel Pyrazole Derivative (LQFM 021)—Possible Effects on Phosphodiesterase

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Electrophysiological effects of disopyramide and quinidine on guinea pig atria and canine cardiac purkinje fibers. Dependence on underlying cholinergic tone

Michael Mirro

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Novel diazinone derivatives separate myofilament Ca2+ sensitization and phosphodiesterase III inhibitory effects in guinea pig myocardium

inge lues

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Ischemia-dependent efficacy of phosphodiesterase inhibition☆

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Design, synthesis and evaluation of N2,N4-diaminoquinazoline based inhibitors of phosphodiesterase type 5

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Phosphodiesterase inhibition and Ca2+ sensitization

Michael Fluss

Molecular and Cellular Biochemistry, 1996

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Proteolysis of cyclic AMP phosphodiesterase-II attenuates its ability to be inhibited by compounds which exert positive inotropic actions in cardiac tissue

Brendan Price

Biochemical Pharmacology, 1987

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Effect of an antihypertensive hydrazine derivative on Ca2+ current of single frog cardiac cells

giau tran

European Journal of Pharmacology: Molecular Pharmacology, 1993

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