Is Axon Guidance by Attraction and Repulsion, or by a Roll of the Dice? (original) (raw)

Abstract

Attractants and repellants guide axons to their targets. On its journey, a migrating axon may be confronted with multiple attractive and repulsive guidance cues. This presents a conundrum. How does the axon avoid a tug-of-war between attractants and repellants? Does the strongest cue win? Can one cue negate the effects of another? Can an axon switch its responsiveness to cues until they all match? Our study suggests that the key to understanding this problem may lie within the realm of probability theory.

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