Correlation of clinical, radiological and serum analysis of hypovitaminosis D with polycystic ovary syndrome: A systematic review and meta-analysis (original) (raw)
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International Journal of Life Science and Pharma Research
Polycystic ovarian syndrome (PCOS) is the most common heterogeneous multisystem endocrinopathy in women of reproductive age, with an ovarian manifestation of various metabolic disturbances. Based on Rotterdam criteria, PCOS is further classified into four phenotypes. Vitamin D deficiency affects 65- 75% of PCOS patients. There is very little research on the relationship between vitamin D deficiency and PCOS phenotypes. As a result, we intended to investigate the relationship between vitamin D, PCOS, and various PCOS phenotypes. This is a case-control study where we had been 100 people in the study. A total of 50 PCOS participants were classified into phenotype A, phenotype B, phenotype C, and phenotype D using Rotterdam criteria. There were 50 participants who did not have PCOS. Serum vitamin D levels were measured in the study population. The CIDRF (Central Inter-Disciplinary Research Facility) used an ELISA kit and reader to quantify vitamins. The results obtained were further cla...
PCOS Physiopathology and Vitamin D Deficiency: Biological Insights and Perspectives for Treatment
Journal of Clinical Medicine
Recent literature has stressed the importance of vitamin D (VD) in polycystic ovary syndrome (PCOS). Women with PCOS are deficient in VD, particularly those with a higher weight. Hypovitaminosis is a risk factor for glucose intolerance, and reduced levels of VD is associated with insulin resistance and increased diabetes risk. Since women with PCOS and hirsutism seem to have lower levels of VD than women with PCOS without hirsutism, a correlation between VD deficiency and hyperandrogenism may be suggested. Interestingly, VD is crucial for many human physiological functions, including to counteract inflammation and oxidative stress. Some studies evaluated effects of VD supplementation on glucose homeostasis variables, hormonal status, lipid concentrations, and biomarkers of inflammation and oxidative stress among VD-deficient women. Moreover, VD has been shown to play a role in egg quality and fertility. This review aims to show the relationship between VD and the endocrine and metab...
International Journal of Reproduction, Contraception, Obstetrics and Gynecology
Background: Polycystic ovarian syndrome is the most common hormonal disturbance in the reproductive age women, with prevalence of 5-10%. Vitamin D deficiency is common in women with or without PCOS. The aim of this study was to assess association of serum vitamin D level with metabolic and endocrine dysregulation in women with PCOS.Methods: This cross-sectional study was done over a period of one year. 100 women of age group 20-40 years were divided in group A 30 (BMI >30 mg/m2) with PCOS, group B 20 (BMI <25 mg/m2) with PCOS, group C 50 controls and were investigated for serum FSH, LH, LH/FSH ratio, S. total testosterone, S. postprandial insulin level, glucose insulin ratio, 25 hydroxy vitamin D level.Results: LH/FSH ratio >2 (33.33% in obese and 50% in non-obese), serum total testosterone level >0.8ng/ml (80% in obese and 75% in non-obese) (p value was significant between study group as well as between study and control group). Serum fasting, postprandial blood glucose...
ASSESSMENT OF VITAMIN D AND CALCIUM LEVELS IN WOMEN WITH PCOS: AN OBSERVATIONAL STUDY
Asian Journal of Pharmaceutical and Clinical Research Journal, 2022
Objectives: Polycystic ovarian syndrome (PCOS) is a prevalent endocrinal disorder in the women of reproductive age group. The present study aims to investigate the correlation between Vitamin D and calcium levels in PCOS subjects as well as to establish the correlation between body mass index, hyperandrogenism, and metabolic syndrome in various phenotypes of PCOS. Methods: In the present prospective and observational study, a total of 80 patients diagnosed with PCOS were recruited. The recruited patients were divided in the following two groups-study group (60 women diagnosed with PCOS based on Rotterdam criteria); and control group (20 women without PCOS recruited from outpatient department and infertility clinics). Baseline characteristics, Vitamin D level, and serum calcium levels were measured in the two groups and then compared. Results: The mean age of patients in both the groups was found to be comparable (study group: 26.45±5.95 years versus control group: 28.40±6.65 years; p=0.221). The difference of mean 25-Hydroxy Vitamin D3 level was found to be statistically highly significant (study group 14.71 [±9.12] ng/mL versus control group was 22.47 [±6.71] ng/mL; p=0.0008). The difference of mean serum calcium level was also found to be statistically highly significant (study group 9.14 [±0.50] mg/mL, and control group 9.74 [±0.45] mg/mL; p<0.0001). Conclusion: Women with PCOS have a significantly lower serum 25-hydroxyvitamin D and calcium levels as compared to controls. There is need for routine Vitamin D3 and calcium screening in all patients of PCOS for better insight into its role in the syndrome. Screening and correction of Vitamin D3 and calcium deficiency may prevent PCOS and its manifestations.
Role of Vitamin D in the Etiology of Polycystic Ovary Syndrome, A Review
2018
Polycystic ovary syndrome (PCOS) is a common cause of ovarian dysfunction in women suffering from anovulation. It is characterized by chronic anovulation, hyperandrogenism, and/or the presence of polycystic ovaries on ultrasonography. No single etiologic factor fully accounts for the spectrum of abnormalities in PCOS. Interactions between genetic and environmental factors such as genetic, gonadotropins and insulin contribute to the pathogenesis of PCOS. Vitamin D deficiency among PCOS women is prevalent and reaches 67 to 85 percent. The prevalence of vitamin D deficiency has been found to be associated with metabolic syndrome which may have great impact on public health. Low 25(OH)D levels may exacerbate the symptoms of PCOS, including insulin resistance, ovulatory, menstrual irregularities, infertility, hyperandrogenism, obesity and elevate the risk of cardiovascular diseases. Many observational studies suggest a possible role of vitamin D in an inverse association between vitamin ...