Spectrum of pediatric brain tumors in India: A multi-institutional study (original) (raw)
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Spectrum of pediatric brain tumors: a report of 341 cases from a tertiary cancer center in India
Indian journal of pediatrics, 2014
Brain tumors are the second most common cancers after hematological malignancies accounting for approximate 21% of all childhood malignancies in children between ages of 0 and 14 y. The present study was undertaken to determine the spectrum of the brain tumors diagnosed in a tertiary cancer center in South India. A retrospective analysis of the data of pediatric brain tumors diagnosed between 2003 and 2009 was done and data was classified according to the age, gender and histology types. Out of 2,844 pediatric patients, 341 (11.99%) were diagnosed as having brain tumors. Most of the patients were in the age group of >5-14 y. Male to female ratio was 1.58:1. The most common pediatric brain tumor was medulloblastoma followed by astrocytoma and ependymoma. Glioblastoma multiforme was the most common subtype of astrocytoma. Other common tumors were glioma, oligodendroglioma, periphereral neuroectodermal tumor and germ cell tumor. As compared to western data, incidence of brain tumors...
Annals of Pathology and Laboratory Medicine, 2016
Background: The primary pediatric brain tumors (PBT) are the second most common cause of death due to malignancies in children. This study was done to analyze the histological spectrum of primary brain tumors in children and also to find out the epidemiology of the common pediatric brain tumors. Methods: Data regarding age, gender, topography, and histopathology of 239 pediatric patients (0–18 years) with brain tumors operated over a period of 15 years (January-2001 to December-2015) was collected and analyzed according to World Health Organization 2007 classification Result: PBTs were more common in males (54.8%) as compared to females (45.2%) with male to female ratio of 1.21:1. Frequency of tumors was higher in childhood age group (>5-<15 years) i.e. (55.6%) when compared to adolescent age group (15.9%). The most common anatomical site was cerebellum (40.5%), followed by hemispheres (21.4%). Supratentorial tumors (51.9%) were predominant than infratentorial tumors (45.2%) a...
Asian Journal of Neurosurgery, 2018
Background: Pediatric brain tumors are unique in terms of distribution, clinical presentation, pathologic types, management, and prognosis. There are not many studies from India which have looked into the epidemiology of pediatric brain tumors. Aims: This study aimed to analyze the epidemiology of pediatric brain tumors in North Kerala and compare it with data from the rest of India and other countries. Materials and Methods: This is a retrospective study of 5-year data of pediatric brain tumors which were operated in a tertiary referral center in North Kerala, India, from 2009 to 2013. The data were procured from the departments of neurosurgery and pathology of the institution. The data were tabulated and analyzed using SPSS software. Results: A total of 71 children had histologically proven brain tumors during the 5-year period. There were 34 boys and 37 girls. Distribution in different age groups was as follows: infancy –5 (7%), 1–5 years –22 (31%), 6–10 years – 21 (29.6%), and 1...
Profile of Primary Pediatric Brain and Spinal Cord Tumors from North India
Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology
The study was carried out to find the profile of pediatric brain and spinal cord tumors during 2006-2015 in a tertiary referral center of North India. It was a retrospective medical record-based observational study. All children <18 years of age with confirmed histopathological diagnosis of cancer were included in the study. Central nervous system (CNS) tumors constituted 5.6% of all pediatric solid malignancies in our hospital. A total of 54 brain tumors and 13 spinal cord tumors were studied. Medulloblastoma was the most common brain tumor (20.3%) followed by pilocytic astrocytoma (16.6%) and glioblastoma multiforme (9.2%). The most common spinal cord tumor was Ewing's sarcoma/primitive neuroectodermal tumor (30.7%) followed by ependymoma (23%). Mean age was 10.5 years and 12.1 years for brain and spinal cord tumors, respectively. There was male predominance in brain tumors while the sex ratio was almost equal in spinal cord tumors. Histomorphologically, necrosis and angiog...
National Journal of Medical Research, 2020
Background: Pediatric brain tumours are the most common solid tumours in children and comprise approximately 20-25% of all pediatric malignancies worldwide. Aims: There is no data about the epidemiological profile of primary brain tumours in pediatric age group from the North-East India. The main aim of the study was to assess the epidemiological profile of pediatric brain tumours in children of the North-Eastern region of India and their patterns of care. Materials and Methods: In this analysis, data regarding age, sex, community, site of the tumour, clinical features, histology, geographical distribution and treatment delivered were collected from hospital cancer registry. Results: A total of 115 cases of pediatric primary brain tumours from age 0-18 years from 2012-2017 were identified and included in this study. According to this study, males (61.7%) slightly outnumbered females (38.3%) with a male: female ratio of 1.61:1 and incidence was most common in the 6-12 years age group. When divided according to anatomical site, primary brain tumours were found to be most common in cerebellum (44.35%) followed by cerebrum (36.26%). Infratentorial tumours (53%) were more than supratentorial tumours (47%). Histologically, the most common variety was found to be Medulloblastoma (34.8%) followed by Astocytomas (26.95%). Patients were mostly seen to belong to Middle Assam region (38.2%). Among the communities, Hindus (61.74%) were most commonly found to have primary pediatric brain tumours. Around 96% of the patients were offered to take radiotherapy out of which only 67% took radiotherapy, 2.6% defaulted treatment(drop outs) and 27% didn’t turn up for treatment. 4.35% of the patients took other modalities of treatment. Conclusion: Multimodality management including surgery, radiotherapy and chemotherapy remains the cornerstone in the management of pediatric brain tumours.
International Journal of Clinical and Diagnostic Pathology, 2019
Tumours of central nervous system occur relatively frequently in early years of life. They are the most common malignancy of childhood after leukaemia in overall cancer incidence. Paediatric brain tumours has histomorphological diversified spectrum & differ significantly from their adult counterpart. Present retrospective observational study was carried out to analyse the histomorphological spectrum of Paediatric CNS tumours at tertiary care centre from central India. This study is an attempt to map the rising trend of paediatric brain tumours in central India. This rise may be due to expansion of available neurosurgical services along with advanced imaging modalities in this part of India. Medulloblastoma, Pilocytic astrocytoma, Ependymoma, Craniopharyngioma & Choroid plexus papilloma were among the top five diagnosis in present study.
IP innovative publication pvt. ltd, 2019
Paediatric brain tumours are the most common solid tumours in children and hence, leading cause of mortality and morbidity in children in our country. Though we have enough statistical data about its epidemiology in western population, there are only a few reports from developing countries like India. Aims: To study the epidemiological patterns of brain tumours in children in our institute. Materials and Methods: It is a medical record based observational study in which retrospective epidemiological approach is used. The records of 50 children <18 years registered in our department suffering from primary brain malignancy over a period of one year are selected. Data regarding age, sex, site of the tumour, clinical features, histology and immunohistochemistry are collected. The World Health Organization classification 2016 of neoplasms is adopted. Results: Male patients falling under the age group of 6-10 years is the most common age group in which these tumours are diagnosed. The most common primary paediatric brain tumours were astrocytic tumours (28%), followed by medulloblastoma (26%) and ependymoma (16%). The most common astrocytic tumour was pilocytic astrocytoma. Conclusion: Our study is an attempt to analyse the epidemiological pattern of paediatric CNS tumours in premiere tertiary care cancer institute of western India which showed the histological profile of paediatric brain tumours in India is like that reported in the Western literature.
2021
Objective: To analyze the histological spectrum of pediatric brain tumors (PBT) in Pakistani population and to compare the results with international data. Study Design: Retrospective observational study. Place and Duration of Study: Armed Forces Institute of Pathology, Rawalpindi, from Jan 2015 and Dec 2019. Methodology: This data was analyzed using the latest World Health Organization (WHO) classification of Tumors of Central Nervous System 2016. The cases were divided in 5 categories according to age (0-2, 3-5, 6-8, 9-11 & 12-14 years). Results: A total of 43 cases were included in the study. Of these cases, 26 (60.46%) were male and 17 (39.5%) were female. Male to female ratio was 1.5-1. The 6-8 year age group had the highest number of tumors while 0-2 year age group had the least. Mean age of diagnosis was 7.6 years. Ependymoma wasthe most common morphological type with 12 cases (28%) followed by pilocytic astrocytoma, diffuse glioma with 10 cases each (23%) and medulloblastoma...
Middle East Journal of Cancer, 2018
Background: Treatment of childhood brain tumours requires coordinated efforts by multiple specialities-neurosurgery, neuroradiology, neuropathology, oncology, and radiotherapy. The outcome is worse in developing countries compared to developed countries because of deficiencies in proper registry, failure of timely diagnosis, lack of availability and coordination of multiple specialists required for comprehensive management and high abandonment rates. Method: The pediatric neuro-oncology program was initiated in collaboration with the neighbouring neurosurgery institution as a step towards improving care for pediatric brain tumor patients in our hospital. Epidemiology, treatment and followup of brain tumours in children aged 1-14 years attending the pediatric oncology department were studied. Patients received multimodality treatment with surgery, radiotherapy and chemotherapy by specialists in both centres. The study period was from January 2008 to December 2012. Results: There were 375 pediatric brain tumour patients during the study period. 166 patients (44.2%) had supratentorial tumors and 209 (55.73%) had infratentorial tumors. 42.6% of tumours were high-grade and 53.6% were low grade. The commonest histopathological tumour type was astrocytoma (48.8%) followed by medullobastoma (24.5%). 287 (76.5%) patients underwent surgery, 216 (57.6%) patients received radiotherapy, 97 (25.8%) patients received chemotherapy and 94 (25%) required follow-up only. Patient follow-up rates improved from 37.2% to 82.6% and treatment abandonment decreased from 35.8% to 14.8% over these years. Conclusions: Impact of the pediatric neuro-oncology program in our hospital has made it possible to provide comprehensive multidisciplinary treatment in a coordinated manner, describe the epidemiology of pediatric brain tumors, reduce treatment abandonment, and improve the follow-up of pediatric brain tumour patients.