behalf of the KRASTENT Study Group 1 (original) (raw)

Abstract

Digestive and Liver Disease j o u r n a l h o m e p a g e : w w w . e l s e v i e r . c o m / l o c a t e / d l d Oncology Influence of K-ras status and anti-tumour treatments on complications due to colorectal self-expandable metallic stents: A retrospective multicentre study a b s t r a c t Background: This study aimed to explore the relationship between K-ras status, anti-tumour treatments, and the complications of colorectal self-expandable metallic stenting in colorectal cancer. Methods: This is a retrospective, multicentre study of 91 patients with obstructive advanced colorectal cancer palliated with enteral stents between 2007 and 2011. Results: K-ras wild-type tumours were diagnosed in 44 patients (48.4%); 82 (90.1%) received chemother-apy and 45 (49.4%) had additional biological therapy (34 bevacizumab, 11 cetuximab). Twenty-one (23.1%) experienced stent-related complications: 11 (52.4%) occurred in the K-ras mutant group (P = 0.9). K-ras wild-type patients were not less l...

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