Proprotein convertase subtilisin/kexin type 9 is a psoriasis-susceptibility locus that is negatively related to IL36G (original) (raw)

AI-generated Abstract

The study investigates the role of proprotein convertase subtilisin/kexin type 9 (PCSK9) as a potential susceptibility locus for psoriasis, revealing an inverse relationship between PCSK9 and IL36G expression in skin keratinocytes. Through RNA-Seq and single-cell RNA-Seq analyses, the research presents evidence of PCSK9's regulatory influence on inflammatory cytokines, establishing it as a significant factor in psoriasis pathophysiology.

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