Nanoparticle release from anionic nanocellulose hydrogel matrix (original) (raw)
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Controlled drug release from hydrogel nanoparticle networks
Journal of Controlled Release, 2004
Monodisperse nanoparticles of poly-N-isopropylacrylamide-co-allylamine (PNIPAM-co-allylamine) and PNIPAM-coacrylic acid (PNIPAM-co-AA) were synthesized. The close-packed PNIPAM-co-allylamine and PNIPAM-co-AA nanoparticles were converted to three-dimensional gel networks by covalently crosslinking neighboring particles at room temperature and neutral pH using glutaric dialdehyde and adipic acid dihydrazide, respectively. Controlled release studies were conducted using dextran markers of various molecular weights as model macromolecular drugs. Release was quantified under various physical conditions, including a range of temperatures and dextran molecular weights. Dextran, entrapped in cavities in the nanoparticle network, was released with a rate regulated by their molecular weights and cavity size. No release from a conventional bulk PNIPAM gel, with high crosslinking density, was observed. The rate of release from the PNIPAM-co-allylamine network was temperature-dependant, being much faster at room temperature than that at human body temperature. In contrast, release of low molecular weight dextrans from the PNIPAM-co-AA network showed a temperature-independent release profile. These nanoparticle networks have several advantages over conventional bulk gels for controlling the release of high molecular weight biomolecules. D
Macromolecular bioscience, 2017
A hybrid hydrogel composed of solid lipid nanoparticles (LNPs) entrapped within chemically cross-linked carboxymethylcellulose (CMC) is developed to achieve localized and sustained release of lipophilic drugs. The analysis of LNP stability as well as the hydrogel swelling and mechanical properties confirm the successful incorporation of particles up to a concentration of 50% w/wCMC . The initial LNP release rate can be prolonged by increasing the particle diameter from 50 to 120 nm, while the amount of long-term release can be adjusted by tailoring the particle surface charge or the cross-linking density of the polymer. After 30 d, 58% of 50 nm diameter negatively charged LNPs escape from the matrix while only 17% of positively charged nanoparticles are released from materials with intermediate cross-linking density. A mathematical diffusion model based on Fick's second law is efficient to predict the diffusion of the particles from the hydrogels.
International Journal of Advance Research , 2024
Nanoparticles loaded hydrogel has emerged as a promising strategy in the field of drug delivery systems, offering unique advantages in terms of controlled release, enhanced bioavailability, and targeted delivery of therapeutic agents. Nanoparticles, typically ranging from 1 to 100 nanometers in size, serve as carriers for drugs, encapsulating them within their matrix and protecting them from degradation. Hydrogels, on the other hand, are three-dimensional cross-linked networks of hydrophilic polymers capable of absorbing and retaining large amounts of water. It aims to provide acomprehensive understanding of nanoparticles loaded hydrogel in drug delivery systems by elucidating the relationship between nanoparticles and hydrogels and their synergistic effects on drug delivery. Firstly, the properties of nanoparticles, including size, surface charge, and composition, significantly influence their interactions with hydrogels and the encapsulation efficiency of drugs. Secondly, the unique characteristics of hydrogels, such as tunable swelling behavior and biocompatibility, complement the stability and sustained release kinetics of nanoparticles.Furthermore, the incorporation of nanoparticles into hydrogel matrices enhances their mechanical strength and allows for the development of stimuli-responsive systems, enabling on-demand drug release triggered by external stimuli such as pH, temperature, or magnetic fields. The synergistic combination of nanoparticles and hydrogels opens up new avenues for the design of advanced drug delivery systems with improved therapeutic efficacy and reduced side effects. In conclusion, nanoparticles loaded hydrogel represents a promising platform for the development of next-generation drug delivery systems, offering unprecedented control over drug release kinetics and targeting capabilities. This review highlights the importance of understanding the interplay between nanoparticles and hydrogels in optimizing the performance of drug delivery systems for various biomedical applications.
REVIEW ON NANOGEL AS TARGATED CONTROLLED DRUG RELEASE
Int J Biol Med Res. 2024; 15(4): 7923-7925
Nanogel is nanoparticles synthesized by combining a hydrogel and a cross-linked hydrophilic polymer. These Nanogels have emerged as promising drug-carrying agents for targeting cancer cells because they can be easily formed and tailored.Nanogels and microgels are soft, deformable, and penetrable objects with an internal gel-like structure that is swollen by the dispersing solvent. Their softness and the potential to respond to external stimuli like temperature, pressure, pH, ionic strength, and different analytes make them interesting as soft model systems in fundamental research as well as for a broad range of applications, in particular in the field of biological applications. Recent tremendous developments in their synthesis open access to systems with complex architectures and compositions allowing for tailoring micro gels with specific properties. At the same time state-of-the-art theoretical and simulation approaches offer deeper understanding of the behavior and structure of nano-and microgels under external influences and confinement at interfaces or at high volume fractions. Developments in the experimental analysis of nano-and microgels have become particularly important for structural investigations covering a broad range of length scales relevant to the internal structure, the overall size and shape, and interparticle interactions in concentrated samples. Here we provide an overview of the state-of-the-art, recent developments as well as emerging trends in the field of nano-and micro gels
The main objective of this research is to investigate how curcumin liposomal nanocarriers influence the drug release behaviour of PVA/PEG hydrogels in relation to physico-mechanical properties. For this purpose, optimal nanoliposomes from drug loading and release viewpoints, prepared by the thin-film hydration method, were incorporated into the hydrogel composition. Hydrogel samples were physically crosslinked using the freeze-thaw procedure. According to the atomic force microscopy and field-emission scanning electron microscopy observations, nanoliposomes showed a spherical morphology with an average particle size of 100 nm and narrow size distribution. The X-ray diffraction results revealed that adding nanoliposomes to the hydrogel increases the degree of PVA chains crystallinity, enhances tensile modulus and tensile strength of the hydrogel, while decreasing swelling and dehydration rates. SEM micrographs observation displayed that the porosity in the hydrogel structure in the p...
Lipid-hydrogel films for sustained drug release
International Journal of Pharmaceutics, 2015
We report a hybrid system, fabricated from nanostructured lipid particles and polysaccharide based hydrogel, for sustained release applications. Lipid particles were prepared by kinetically stabilizing selfassembled lipid nanostructures whereas the hydrogel was obtained by dissolving kappa-carrageenan (KC) in water. The drug was incorporated in native as well as lipid particles loaded hydrogels, which upon dehydration formed thin films. The kinetics of drug release from these films was monitored by UV-vis spectroscopy while the films were characterized by Fourier transform infra-red (FTIR) spectroscopy and small angle X-ray scattering techniques. Pre-encapsulation of a drug into lipid particles is demonstrably advantageous in certain ways; for instance, direct interactions between KC and drug molecules are prohibited due to the mediation of hydrophobic forces generated by lipid tails. Rapid diffusion of small drug molecules from porous hydrogel network is interrupted by their encapsulation into rather large sized lipid particles. The drug release from the lipid-hydrogel matrix was sustained by an order of magnitude timescale with respect to the release from native hydrogel films. These studies form a strong platform for the development of combined carrier systems for controlled therapeutic applications.
International Journal of Pharmaceutics
Concentrated 3 % and 6.5 % anionic nanofibrillar cellulose (ANFC) hydrogels were introduced as matrix reservoirs for controlled delivery applications of small molecules and proteins. A further aim was to study how the freeze-drying and subsequent rehydration of ANFC hydrogel affects the rheological properties and drug release of selected model compounds from the reconstructed hydrogels. It was demonstrated that the 3 % and 6.5 % ANFC hydrogels can be freeze-dried with suitable excipients into highly porous aerogel structures and redispersed back into the hydrogel form without significant change in the rheological properties. Freeze-drying did not affect the drug release properties from redispersed ANFC hydrogels, indicating that these systems could be stored in the dry form and only redispersed when needed. For large molecules, the diffusion coefficients were significantly smaller when higher ANFC fiber content was used, indicating that the amount of ANFC fibers in the hydrogel can be used to control the release rate. The release of small molecules was controlled with the ANFC fiber content only to a moderate extent. The results indicate that ANFC hydrogel can be used for controlled delivery of several types of molecules and that the hydrogel can be successfully freeze-dried and redispersed.
An Overview of Nanogel Drug Delivery System ARTICLE INFO ABSTRACT
Nanogels based materials have high drug loading capacity, biocompatibility, and biodegradability which are the key points to design a drug delivery system effectively. The pursuit of this review article is to concisely describe the recent development of nanogel drug delivery system in terms of drug loading and swelling of drug from nanogels. Furthermore, biomedical application and current clinical trial studies of nanogel are summarized briefly. Here, different types of nanogels along with the synthetic procedure and mechanism of drug release from nanogel carrier are mainly focused. An intensive study of clinical trial in future will confirm nanogel as a suitable carrier for drug delivery.
Hydrogels and nanogels as a promising carrier for drug delivery
IntechOpen eBooks, 2023
Among the drug delivery systems, hydrogels and nanogels have shown a vital role because of their advantageous 3D crosslinked networks. They have the propensity to absorb water due to their hydrophilic groups, making them excellent superabsorbents that are water-insoluble. Nanogels are crosslinked nano-sized hydrogels (20-200 nm) with greater tissue permeation due to their smaller size. Hydrogels and nanogels demonstrate many advantages, including biocompatibility, hydrophilicity, controlled drug release, and smart drug delivery. They are regarded as an interesting approach for the controlled release of medications since they can encapsulate drug molecules in their water-swollen network. Recent advances in polymer chemistry and nanotechnology have resulted in several significant improvements in the field of hydrogels and nanogels as drug delivery systems. In this chapter, the properties of hydrogels and nanogels, as well as their classification, drug release mechanisms, and applications for drug delivery, will be discussed.
An Overview of Nanogel Drug Delivery System
Journal of Applied Pharmaceutical Science
Nanogels based materials have high drug loading capacity, biocompatibility, and biodegradability which are the key points to design a drug delivery system effectively. The pursuit of this review article is to concisely describe the recent development of nanogel drug delivery system in terms of drug loading and swelling of drug from nanogels. Furthermore, biomedical application and current clinical trial studies of nanogel are summarized briefly. Here, different types of nanogels along with the synthetic procedure and mechanism of drug release from nanogel carrier are mainly focused. An intensive study of clinical trial in future will confirm nanogel as a suitable carrier for drug delivery.