Immunoglobulin genes implicated in glioma risk (original) (raw)

This study investigates the association between immunoglobulin heavy chain gamma (IGHG) gene polymorphisms and glioma risk. Specifically, the role of γ marker (GM) allotypes was examined in glioma patients compared to healthy controls, revealing that the GM 3 allele is linked to a significantly increased risk of glioma, particularly high-grade astrocytomas. The findings suggest that these genetic factors may influence the immune response to human cytomegalovirus, a potential contributor to gliomagenesis.