Significant linkage and non-linkage of type 1 von Willebrand disease to the von Willebrand factor gene (original) (raw)

Abstract

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The study investigates the genetic underpinnings of type 1 von Willebrand disease (VWD) and aims to clarify the role of the von Willebrand factor (VWF) gene in this hereditary bleeding disorder. It highlights the occurrence of significant linkage in some variants of VWD, while pointing out the lack of such linkage in type 1 VWD. Various indirect genetic analyses were conducted on families with type 1 VWD, aiming to determine the relationship between phenotype and the VWF locus, and the potential influence of blood group on disease expression was also explored.

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