Prevalence of thyroid disorders in antenatal women and its impact on maternal and foetal outcome (original) (raw)
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International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2017
Background: Pregnancy is associated with major changes in the physiology of the thyroid gland. Undiagnosed thyroid disorders can adversely affect fetal and maternal outcome. This study was done to study the prevalence of thyroid disorder among antenatal women.Methods: This was a prospective study done in the antenatal clinic in the Department of Obstetrics and Gynaecology, ESI PGIMSRMGM Hospital, Parel, Mumbai, India.Results: In present study, fifty out of three hundred and fifty pregnant women screened had thyroid disorder. The prevalence of thyroid disorder in this study was 14.2%. The prevalence of subclinical hypothyroidism was 7.7% (n= 27), overt hypothyroidism was 4% (n=14), subclinical hyperthyroidism was 1.7% (n=6) and overt hyperthyroidism was 0.8% (n=3).Conclusions: Thyroid disorders in pregnancy are associated with adverse fetomaternal outcome. Its prevalence is high in Indian women. Thus thyroid screening should be included in the routine antenatal investigations.
Indian Journal of Endocrinology and Metabolism, 2015
Background: Undetected and untreated thyroid disorders are associated with adverse maternal and fetal outcomes. There are limited data on the prevalence of newly diagnosed thyroid disease during pregnancy from India. Therefore, this study was designed to evaluate the prevalence of thyroid dysfunction, especially hypothyroidism during the first trimester of pregnancy. Materials and Methods: The present cross-sectional study was conducted at Department of endocrinology and antenatal clinic in the Obstetrics and Gynecology Pt. B.D. Sharma PGIMS, Rohtak over a period of 1-year. The total sample population comprised of 461 pregnant women with uncomplicated intrauterine singleton pregnancies in the first trimester of gestation without any history of thyroid disease or intake of any thyroid medication. Morning blood samples from the participants were analyzed for thyroid function tests, which included FT3, FT4, thyroid-stimulating hormone (TSH) and anti-thyroid peroxidase antibodies (TPO). Results: A total of 461 women were enrolled for this study. Mean maternal age was 23.79 ± 3.47 years. Median gestational age was 8 weeks 5 days. The median FT3, FT4 and TSH were 3.3 pg/mL, 1.25 ng/dL, and 1.40 mIU/L, respectively. Anti-TPO was elevated in 128 (27.8%) pregnant women. 99 (21.5%) women had sub-clinical hypothyroidism and 39 (39.4%) among them were positive for anti-TPO (P ≤ 0.001). 2 (0.4%) of women had overt hyperthyroidism, whereas 15 (3.3%) of the women had sub-clinical hyperthyroidism. Conclusion: Considering the immense impact that maternal thyroid dysfunction has on maternal and fetal outcomes, prompt identification of thyroid dysfunction and its timely treatment is essential. Thus, universal screening of pregnant women for thyroid dysfunction should be considered especially in a country like India due to the high prevalence of thyroid dysfunction.
International Journal of Reproduction, Contraception, Obstetrics and Gynecology
Background: Thyroid dysfunction is the commonest endocrinological disorder in pregnancy. A broad spectrum of adverse outcomes in pregnant women and the fetus have been reported which can be prevented by early diagnosis and treatment of thyroid dysfunction. Thyroid dysfunction in pregnancy has not yet been extensively studied in India. Hence, this study was conducted for assessment of the prevalence of thyroid dysfunction in pregnancy and effect on the mother and her fetus.Methods: This study is a prospective study conducted in the department of obstetrics and gynecology, MIMER Medical College and Hospital, Talegaon Dabhade, Maharashtra. A 3 years study. Antenatal women attending the outpatient and inpatient department of the hospital. The total sample population comprised of 698 pregnant women with uncomplicated singleton intra-uterine pregnancy. All participants were screened by estimation for serum TSH in first trimester. Immediately after delivery the cord blood sample was collec...
International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2018
Background: The aim of the study is to determine the prevalence of thyroid dysfunction in pregnancy and its impact on obstetrical outcome in Eastern Uttar Pradesh.Methods: This was a prospective observational study undertaken at antenatal clinics and indoor of BRD Medical College, Gorakhpur. Total 720 antenatal women, ≤20 weeks of gestation were recruited for the study. In all patients’ routine obstetrical investigations and thyroid function tests were done. All patients were followed up to delivery. Maternal and perinatal outcome were ascertained.Results: Prevalence of thyroid dysfunction among pregnant was found to be 21.1% and subclinical hypothyroidism (15.9%) was the commonest thyroid disorder. Most common complication observed in subclinical and overt hypothyroidism was preeclampsia (9.56 % versus 20%) followed by preterm labour (7.82% versus 10%). Major fetal complications in hypothyroid mothers included intrauterine growth restriction, low birth weight and stillbirth.Conclus...
Prevalence of Thyroid Dysfunction in Pregnancy and Its Outcome: The Indian Scenario
https://www.ijrrjournal.com/IJRR\_Vol.5\_Issue.8\_Aug2018/Abstract\_IJRR0028.html, 2018
Thyroid gland is the most important endocrinal gland in the human's body. It plays the important role in maintaining the metabolic rate and body's homeostasis mechanism. [12] But however some physiological changes occur during the pregnancy. This leads to increased and decreased in level of thyroid hormone. All pregnant women shows the increased risk for subclinical hypothyroidism with maternal and fetal complication such as preeclampsia, abortion, abruption placenta, preterm labor, anemia, miscarriage, postpartum hemorrhage, prematurity, low birth weight, still birth, perinatal death and intrauterine growth retardation. This complication was highly due to delayed diagnosis and lack of knowledge among public. As this study conclude the early screening of thyroid function, prompt diagnosis and counseling to the patient will reduce the incidence of hypothyroidism.
International journal of reproduction, contraception, obstetrics and gynecology, 2018
Background: Thyroid dysfunction is known to be the commonest endocrinological disorder in pregnancy. A range of adverse outcomes in pregnant women and the fetus have been reported. These can be prevented if the thyroid dysfunction is diagnosed and treated as early as possible. There are limited studies conducted on the prevalence of thyroid dysfunction in pregnancy in India. Hence, this study was conducted for assessment of the prevalence of thyroid dysfunction in pregnancy. Methods: The present study is a prospective study conducted in the
Archives of Gynecology and Obstetrics, 2010
Purpose Thyroid disorders are among the common endocrine problems in pregnant women. It is now well established that not only overt, but subclinical thyroid dysfunction also has adverse eVects on maternal and fetal outcome. There are few data from India about the prevalence of thyroid dysfunction in pregnancy. With this background, this study aims to Wnd prevalence of thyroid dysfunction in pregnancy and its impact on obstetrical outcome in Indian population. Methods Six hundred and 33 pregnant women in second trimester were registered. Detailed history and examination was done. Apart from routine obstetrical investigations, TSH level estimation was done. If TSH level was deranged then free T 4 and thyroperoxidase antibody level estimation were done. Patients were managed accordingly and followed till delivery. Their obstetrical and perinatal outcomes were noted. Results Prevalence of thyroid dysfunction was high in this study, with subclinical hypothyroidism in 6.47% and overt hypothyroidism in 4.58% women. Overt hypothyroids were prone to have pregnancy-induced hypertension (P = 0.04), intrauterine growth restriction (P = 0.01) and intrauterine demise (P = 0.0004) as compared to control. Cesarean section rate for fetal distress was signiWcantly higher among pregnant subclinical hypothyroid women (P = 0.04). Neonatal complications and gestational diabetes were signiWcantly more in overt hyperthyroidism group (P = 0.03 and P = 0.04, respectively). Conclusions Prevalence of thyroid disorders, especially overt and subclinical hypothyroidism (6.47%) was high. SigniWcant adverse eVects on maternal and fetal outcome were seen emphasizing the importance of routine antenatal thyroid screening.
International Journal of Clinical Obstetrics and Gynaecology, 2021
Background: The thyroid dysfunctions are quite common endocrinal disorders seen during pregnancy and the maternal thyroid dysfunctions may go unnoticed due to nonspecific symptoms. The maternal thyroid dysfunction has an adverse impact on both maternal and fetal outcome. The evaluation of thyroid functioning during first trimester avoids complications both in mother and fetus. The present study was conducted to assess the maternal thyroid functions (T3, T4, &TSH) during first trimester of pregnancy and also to determine the proportion of thyroid dysfunction in these subjects. Method: One hundred and thirty five apparently normal first trimester pregnant women were randomly selected in the age group of 18-45 years from obstetric outpatient department of S.D M Medical College, Dharwad. The FT3, FT4 &TSH values were estimated using chemiluminescent immune assay method and TPO antibodies for abnormal thyroid functions. Conclusion: A high proportion of hypothyroid (15.5% hypothyroid range) was observed in first trimester of pregnancy, and hence a routine antenatal screening is suggested to diagnose the thyroid dysfunction at the earliest gestation.
Prevalence of thyroid disorders among pregnant women at a tertiary care hospital in Rajasthan
2021
Pregnancy can be viewed as a state in which a combination of events concur to modify the thyroidal economy. There is change in the level of thyroxinebinding globulin, total thyroid hormone level and change in the level of thyroid stimulating hormone (TSH) during normal pregnancy. Endemic iodine deficiency accounts for most of the cases of hypothyroidism in pregnant women worldwide while chronic autoimmune thyroiditis is the most common cause of hypothyroidism in iodine sufficient parts of the world. The presentation of hypothyroidism in pregnancy is not always classical and may sometimes be difficult to distinguish from the ABSTRACT
Annals of International medical and Dental Research, 2018
Background: In our country there is paucity of studies related to thyroid dysfunctions in pregnancy. Hence the present study was planned to evaluate the prevalence of thyroid disorders in second trimester of pregnancy. Methods: Assay of FT3, FT4 and TSH were done in 100 pregnant women in their second trimester of pregnancy selected from Obstetrics & Gynaecology OPD. Results: Out of total 100 women, 35 (35%) had sub-clinical hypothyroidism and 32 (32%) of them had overt hypothyroidism. None of the women had either sub-clinical hyperthyroidism or overt hyperthyroidism. Conclusion: Universal screening in pregnancy should be done in country like India for thyroid disorders as the prevalence of these undiagnosed thyroid dysfunctions is high.