GASTRORETENTIVE SYSTEM IMPROVES THE PROBLEMS OF ORAL DRUG DELIVERY SYSTEMS: A REVIEW (original) (raw)

Gastroretention helps to provide better availability of new products with new therapeutic possibilities and substantial benefits for patients. Dosage forms with a prolonged gastric residence time, i.e. gastro retentive dosage forms (GRDFs), will provide us with new and important therapeutic options. GRDFs extend significantly the period of time over which the drug may be released. Thus, they not only prolong dosing intervals, but also increase patient compliance beyond the level of existing controlled release dosage forms. This application is especially effective in delivery of sparingly soluble and insoluble drugs. A number of approaches have been used to increase the GRT of a dosage form in a variety of concepts. These include Floating drug delivery systems, Bioadhesive systems, Swelling and expanding systems, Modified shape systems and High density drug delivery systems. This review also discusses the recent advances in the field of gastroretentive drug delivery systems. KEYWORDS: Delivery System, Gastroretentive, Gastric Residence Time, Bioavailability.

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