Silver Nanoparticles as Potential Antiviral Agents (original) (raw)
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Silver Nanoparticles: Review of Antiviral Properties, Mechanism of Action and Applications
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New antiviral drugs and new preventive antiviral strategies are a target of intense scientific interest. Thanks to their peculiar properties, nanomaterials play an important role in this field, and, in particular, among metallic materials, silver nanoparticles were demonstrated to be effective against a wide range of viruses, in addition to having a strong antibacterial effect. Although the mechanism of antiviral action is not completely clarified, silver nanoparticles can directly act on viruses, and on their first steps of interaction with the host cell, depending on several factors, such as size, shape, functionalization and concentration. This review provides an overview of the antiviral properties of silver nanoparticles, along with their demonstrated mechanisms of action and factors mainly influencing their properties. In addition, the fields of potential application are analyzed, demonstrating the versatility of silver nanoparticles, which can be involved in several devices a...
Application of Silver Nanoparticles in Viral Inhibition: A New Hope for Antivirals
2014
In modern era, viral infections constitute one of the main health problems. Chemically synthesized antiviral drugs have adverse side effects which are associated with other health complications. The emergence of new infectious diseases and increase in frequency of drug resistant viruses demand the most effective and novel therapeutic agents, one of which are nanoparticles. Nanoparticles excel as therapeutic agents due to their unique physiochemical properties and a universally applicable physical mode of action. Their large surface area to volume ratio offers them an edge as an antiviral agent. The review focuses on the mechanism of action of silver nanoparticles and their novel therapeutic applications against some viruses bearing potentially fatal consequences.
Silver Nanoparticle as Antiviral Agent and Its Uses
Nano Trends-A Journal of Nano Technology & Its Applications, 2020
Silver had been used by human thousands of years ago as various types of medicines (Rasaratna Samuccahay, Bhagbhatta). As the years passes more scientific uses of silver metals had been seen as the human civilization progresses. After the discovery of nano technology Silver is being used in a variety of ways .Nano particles exhibits less toxicity as compared to their ionic counterpart. Nowadays silver is used in various forms colloidal silver Nanoparticle (AgNPs) is one of the main form of silver, Today is being used in Human body considering toxicity level Colloidal Silver is being used as a new antimicrobial agent having broad microbial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi (Nauran H Assar and Hayam M Hamuoda,2010). Domestic cleaning products enhanced with antimicrobial silver have been patented (Minner and Eatough 2007). Viral infections make disparate need for the development of safe and potent alternatives to conventional antiviral drugs. In now days, nanoscale materials have emerged as novel antiviral agents for the enormous possibilities offered by their unique chemical and physical properties. Colloidal silver or silver nanoparticle has its own antimicrobial properties to combat all types of viruses including human immunodeficiency virus, hepatitis B virus, herpes simplex virus, flu virus etc. Our main focus through this review is to literate the people about this rediscovered material and it has antimicrobial properties which will be very much helpful for the society in long run.
Synthesis approach-dependent antiviral properties of silver nanoparticles and nanocomposites
Journal of Nanostructure in Chemistry
Numerous viral infections are common among humans, and some can lead to death. Even though conventional antiviral agents are beneficial in eliminating viral infections, they may lead to side effects or physiological toxicity. Silver nanoparticles and nanocomposites have been demonstrated to possess inhibitory properties against several pathogenic microbes, including archaea, bacteria, fungi, algae, and viruses. Its pronounced antimicrobial activity against various microbe-mediated diseases potentiates its use in combating viral infections. Notably, the appropriated selection of the synthesis method to fabricate silver nanoparticles is a major factor for consideration as it directly impacts antiviral efficacy, level of toxicity, scalability, and environmental sustainability. Thus, this article presents and discusses various synthesis approaches to produce silver nanoparticles and nanocomposites, providing technological insights into selecting approaches to generate antiviral silver-based nanoparticles. The antiviral mechanism of various formulations of silver nanoparticles and the evaluation of its propensity to combat specific viral infections as a potential antiviral agent are also discussed.
Nanomaterials
Rapid development of nanotechnology has been in high demand, especially for silver nanoparticles (AgNPs) since they have been proven to be useful in various fields such as medicine, textiles, and household appliances. AgNPs are very important because of their unique physicochemical and antimicrobial properties, with a myriad of activities that are applicable in various fields, including wound care management. This review aimed to elucidate the underlying mechanisms of AgNPs that are responsible for their antiviral properties and their antibacterial activity towards the microorganisms. AgNPs can be synthesized through three different methods—physical, chemical, and biological synthesis—as indicated in this review. The applications and limitations of the AgNPs such as their cytotoxicity towards humans and the environment, will be discussed. Based on the literature search obtained, the properties of AgNPs scrutinizing the antibacterial or antiviral effect shown different interaction to...
New Antivirals and Antibacterials Based on Silver Nanoparticles
ChemMedChem, 2020
The rediscovery of the medical uses of silver provides another noticeable example, this time at the interface of chemistry and medicine, of the real (and nonlinear) progress of scientific research. Several new silver‐based antimicrobial products have thus been commercialized in the last two decades. Next‐generation antibacterials and antivirals of broad scope, low toxicity and affordable cost, we argue in this study, will be based on microencapsulated Ag nanoparticles.
Silver nanoparticles are broad-spectrum bactericidal and virucidal compounds
J …, 2011
The advance in nanotechnology has enabled us to utilize particles in the size of the nanoscale. This has created new therapeutic horizons, and in the case of silver, the currently available data only reveals the surface of the potential benefits and the wide range of applications. Interactions between viral biomolecules and silver nanoparticles suggest that the use of nanosystems may contribute importantly for the enhancement of current prevention of infection and antiviral therapies. Recently, it has been suggested that silver nanoparticles (AgNPs) bind with external membrane of lipid enveloped virus to prevent the infection. Nevertheless, the interaction of AgNPs with viruses is a largely unexplored field. AgNPs has been studied particularly on HIV where it was demonstrated the mechanism of antiviral action of the nanoparticles as well as the inhibition the transmission of HIV-1 infection in human cervix organ culture. This review discusses recent advances in the understanding of the biocidal mechanisms of action of silver Nanoparticles.
Metal nanoparticles: The protective nanoshield against virus infection
Critical Reviews in Microbiology, 2014
The promises of nanotechnology have been realized to deliver the greatest scientific and technological advances in several areas. The biocidal activity of Metal nanoparticles in general and silver nanoparticles (AgNPs) depends on several morphological and physicochemical characteristics of the particles. Many of the interactions of the AgNPs with the human body are still poorly understood; consequently, the most desirable characteristics for the AgNPs are not yet well established. Therefore, the development of nanoparticles with well-controlled morphological and physicochemical features for application in human body is still an active area of interdisciplinary research. Effects of the development of technology of nanostructured compounds seem to be so large and comprehensive that probably it will impact on all fields of science and technology. However, mechanisms of safety control in application, utilization, responsiveness, and disposal accumulation still need to be further studied in-depth to ensure that the advances provided by nanotechnology are real and liable to provide solid and consistent progress. This review aims to discuss AgNPs applied in biomedicine and as promising field for insertion and development of new compounds related to medical and pharmacy technology. The review also addresses drug delivery, toxicity issues, and the safety rules concerning biomedical applications of silver nanoparticles. C
Antiviral and Immunomodulatory Activity of Silver Nanoparticles in Experimental RSV Infection
Viruses, 2019
Respiratory syncytial virus (RSV) is an important etiological agent of respiratory infection in children for which no specific treatment option is available. The RSV virion contains two surface glycoproteins (F and G) that are vital for the initial phases of infection, making them critical targets for RSV therapeutics. Recent studies have identified the broad-spectrum antiviral properties of silver nanoparticles (AgNPs) against respiratory pathogens, such as adenovirus, parainfluenza, and influenza. AgNPs achieve this by attaching to viral glycoproteins, blocking entry into the host cell. The objective of this study was to evaluate the antiviral and immunomodulatory effects of AgNPs in RSV infection. Herein we demonstrate AgNP-mediated reduction in RSV replication, both in epithelial cell lines and in experimentally infected BALB/c mice. Marked reduction in pro-inflammatory cytokines (i.e., IL-1α, IL-6, TNF-α) and pro-inflammatory chemokines (i.e., CCL2, CCL3, CCL5) was also observe...
Metal Nanoparticles: a Promising Treatment for Viral and Arboviral Infections
Biological Trace Element Research
Globally, viral diseases continue to pose a significant threat to public health. Recent outbreaks, such as influenza, coronavirus, Ebola, and dengue, have emphasized the urgent need for new antiviral therapeutics. Considerable efforts have focused on developing metal nanoparticles for the treatment of several pathogenic viruses. As a result of these efforts, metal nanoparticles are demonstrating promising antiviral activity against pathogenic surrogates and clinical isolates. This review summarizes the application of metal nanoparticles for the treatment of viral infections. It provides information on synthesis methods, size-related properties, nano-bio-interaction, and immunological effects of metal nanoparticles. This article also addresses critical criteria and considerations for developing clinically translatable nanosized metal particles to treat viral diseases.