The prevalence of hyperprolactinaemia in overt and subclinical hypothyroidism (original) (raw)

HyperprolactInemIa is a common condition that can result from a number of causes, including medication use, hypothyroidism, and pituitary disorders. Depending on the underlying cause and consequences of the hyperprolactinemia, selected patients may require treatment. Hyperprolactinaemia may develop in patients with primary hypothyroidism through a variety of mechanisms. In response to the hypothyroid state, a compensatory increase in the discharge of central hypothalamic thyrotropin-releasing hormone occurs, which results in stimulation of prolactin (PRL) secretion. Furthermore, prolactin elimination from the systemic circulation is reduced, which contributes to increased prolactin concentrations [1-4]. Other reasons