Lignans: Chemical and Biological Properties (original) (raw)
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An update on bioactive plant lignans
Natural Product Reports, 2005
Lignans are a class of secondary plant metabolites produced by oxidative dimerization of two phenylpropanoid units. Although their molecular backbone consists only of two phenylpropane (C 6 -C 3 ) units, lignans show an enormous structural diversity. There is a growing interest in lignans and their synthetic derivatives due to applications in cancer chemotherapy and various other pharmacological effects. This review deals with lignans possessing anticancer, antioxidant, antimicrobial, anti-inflammatory and immunosuppressive activities, and comprises the data reported in more than 100 peer-reviewed articles, so as to highlight the recently reported bioactive lignans that could be a first step towards the development of potential new therapeutic agents.
Lignans: Insight to Chemistry and Pharmacological Applications-An Overview
Lignans are widely distributed in the plant kingdom and have been found in species belonging to more than seventy families. These are found in several foods, mostly in seeds, beans and berries. Sesame seed lignans are perhaps best known for their positive health effects as antioxidants. In recent times, lignans attracted much interest in the researchers due to their wide range of biological applications and their utility as useful synthons. This review describes up to date developments in the lignan chemistry, with a more emphasis on their natural sources, methods developed for synthetic analogues and critical discussion on biological activities.
Lignans and lignins are among the main metabolic products of phenylpropanoid metabolism in vascular plants. They are compounds representing the building blocks of plant cell walls. Moreover they have a broad range of biological activities such as antitumoral, antimitotic, antiviral and cytotoxic and are thought to be involved in the plant defense against pathogens and pests. In this paper we report a survey of the past and current literature about lignans and neolignans and their germination inhibitory activity on cultivated and wild species from plants of the Mediterranean area. Some examples of synthetic methodologies of these molecules have also been reported.
Recent advances in research on lignans and neolignans
Nat. Prod. Rep., 2016
Lignans and neolignans encompass an enormous group of naturally occurring phenols which are widely spread mostly within the plant kingdom. Here, we review the naturally occurring lignans, neolignans, and their glycosides, which have been isolated between 2009 and 2015.
Phytochemical and Biosynthetic Studies of Lignans, with a Focus on Indonesian Medicinal Plants
In this thesis phytochemical and biosynthetic studies of lignans are described. The focus is on the Indonesian medicinal plants Phyllanthus niruri and Piper cubeba and on two Linum species, Linum flavum and L. leonii, native to European countries. Both Indonesian plants are used in jamu. Jamu is the Indonesian traditional herbal medicine, practised for many centuries in the Indonesian community to maintain good health and to treat diseases. The manufacturing of jamu is shifting more and more from household scale to the bigger industries. As the economical and clinical value of jamu nowadays increases in Indonesia, there is a need for further scientific proof and well conducted research. Jamu has to be developed in order to assure its efficacy and safety. Chapter 2 reviews the research carried out on jamu and jamu plants, covering a broad range of aspects including phytochemistry, pharmacology, toxicologicy and clinical studies. In addition, ethical issues such intellectual property ...
Critical Reviews in Food Science and Nutrition, 2020
Lignans are complex diphenolic compounds representing phytoestrogens and occur widely across the plant kingdom. Formed by the coupling of two coniferyl alcohol residues, lignans constitute major plant "specialized metabolites" with exceptional biological attributes that aid in plant defence and provide health benefits in humans by reducing the risk of ailments such as cancer, diabetes etc. Linseed (Linum usitatissimum L.) is one of the richest sources of lignans followed by cereals and legumes. Among the various types of lignans, secoisolariciresinol diglucoside (SDG) is considered as the essential and nutrient rich lignan in linseed. Lignans exhibit established antimitotic, antiviral and anti-tumor properties that contribute to their medicinal value. The present review seeks to provide a holistic view of research in the past and present times revolving around lignans from linseed and its allied species. This review attempts to elucidate sources, structures and functional properties of lignans, along with detailed biosynthetic mechanisms operating in plants. It summarizes various methods for the determination of lignan content in plants. Biotechnological interventions (in planta and in vitro) aimed at enriching lignan content and adoption of integrative approaches that might further enhance lignan content and medicinal and nutraceutical value of Linum spp. have also been discussed.
Lignans: a versatile source of anticancer drugs
Beni-Suef University Journal of Basic and Applied Sciences
Background Cancer is considered as the second deadliest disease globally. Plants have continuously offered unique secondary metabolites with remarkable biological applications. Lignans have gained great importance due to their biological activity. Previous studies revealed that the most remarkable bioactivity of lignan class of molecules is anticancer. They are derived from the oxidative dimerization of two phenylpropanoid units. This review covers the isolated anticancer lignans and their mechanistic aspects. Main body A bibliographic investigation was performed by analyzing the information available on anticancer lignans in the internationally accepted scientific databases including Web of Science, SciFinder, PubMed, Scopus, and Google Scholar. In this review we have tried to sum up the isolated anticancerous lignan, its source, active plant part, extract and various cell lines used to establish different studies. Here we have included a total number of 113 natural lignans. Many s...