REVIEWARTICLE Diagnostic accuracy of 18F amyloid PET tracers for the diagnosis of Alzheimer’s disease: a systematic review and meta-analysis (original) (raw)

2015

Abstract

Imaging or tissue biomarker evidence has been in-troduced into the core diagnostic pathway for Alzheimer’s disease (AD). PET using 18F-labelled beta-amyloid PET tracers has shown promise for the early diagnosis of AD. However, most studies included only small numbers of par-ticipants and no consensus has been reached as to which ra-diotracer has the highest diagnostic accuracy. First, we per-formed a systematic review of the literature published be-tween 1990 and 2014 for studies exploring the diagnostic accuracy of florbetaben, florbetapir and flutemetamol in AD. The included studies were analysed using the QUADAS as-sessment of methodological quality. A meta-analysis of the sensitivity and specificity reported within each study was per-formed. Pooled values were calculated for each radiotracer and for visual or quantitative analysis by population included.

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