99mTc-amoxicillin: a novel radiopharmaceutical for Infection Imaging (original) (raw)

Arabian Journal of Chemistry, 2015

Abstract

ABSTRACT Amoxicillin, a penicillin derivative was synthesized as ready-to-used single vial kit and radiolabeled with technetium-99m. Various trials have been carried out to optimize the concentration of stannous chloride, amoxicillin, pH and reaction time. Radiochemical purity, in vitro and in vivo stability, partition co-efficient, protein binding and biodistribution in rabbit infected with Streptococcus pneumoniae were studied. The biodistribution studies in rabbit showed that 99mTcamoxicillin started to accumulate in the infected area at 1-h post administration. 99mTc-amoxicillin may prove itself as potential novel radiopharmaceutical for imaging infections caused by many bacteria.

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