original ) (raw )Synthesis and Anti-Proliferative Effects of Mono- and Bis-Purinomimetics Targeting Kinases
Mario Cetina
International Journal of Molecular Sciences
View PDFchevron_right
Synthesis of 6,8,9 poly-substituted purine analogue libraries as pro-apoptotic inducers of human leukemic lymphocytes and DAPK-1 inhibitors
Juan J. Diaz-Mochon
Organic & Biomolecular Chemistry, 2015
View PDFchevron_right
Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor
Julie Tucker
Nature Structural Biology, 2002
View PDFchevron_right
Heterobiaryl purine derivatives as potent antiproliferative agents: Inhibitors of cyclin dependent kinases. Part II
LUIS ALICEA
Bioorganic & Medicinal Chemistry Letters, 2009
View PDFchevron_right
Synthesis and Pharmacophore Modelling of 2,6,9-Trisubstituted Purine Derivatives and Their Potential Role as Apoptosis-Inducing Agents in Cancer Cell Lines
Christian Espinosa-bustos
Molecules, 2015
View PDFchevron_right
Promising 2,6,9-Trisubstituted Purine Derivatives for Anticancer Compounds: Synthesis, 3D-QSAR, and Preliminary Biological Assays
Ricardo Tapia
International Journal of Molecular Sciences
View PDFchevron_right
In Vitro Evaluation of a Novel 2,6,9-Trisubstituted Purine Acting As a Cyclin-Dependent Kinase Inhibitor
Vincent Favaudon
Annals of the New York Academy of Sciences, 1999
View PDFchevron_right
Biaryl purine derivatives as potent antiproliferative agents: Inhibitors of cyclin dependent kinases. Part I
Xiaozhang Zheng
Bioorganic & Medicinal Chemistry Letters, 2009
View PDFchevron_right
Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors
Thea Norman
Chemistry & Biology, 1999
View PDFchevron_right
2,6,8,9-Tetrasubstituted Purines as New CDK1 Inhibitors
Jiri Moravec
Bioorganic & Medicinal Chemistry Letters, 2003
View PDFchevron_right
Synthesis and Biological Testing of Purine Derivatives as Potential ATP-Competitive Kinase Inhibitors
Wolfgang Albrecht
Journal of Medicinal Chemistry, 2005
View PDFchevron_right
Structural Basis of Src Tyrosine Kinase Inhibition with a New Class of Potent and Selective Trisubstituted Purine-based Compounds
Raji Sundaramoorthi
Chemical Biology <html_ent glyph="@amp;" ascii="&"/> Drug Design, 2006
View PDFchevron_right
Cyclin-Dependent Kinase Inhibition by New C-2 Alkynylated Purine Derivatives and Molecular Structure of a CDK2−Inhibitor Complex
David Grierson
Journal of Medicinal Chemistry, 2000
View PDFchevron_right
Purine analogs as phosphatidylinositol 4-kinase IIIβ inhibitors
Ivana Mejdrová
Bioorganic & medicinal chemistry letters, 2016
View PDFchevron_right
Design, Synthesis and Anticancer Activity Against the MCF-7 Cell Line of Benzo-Fused 1,4-Dihetero Seven- and Six-Membered Tethered Pyrimidines and Purines
Ana Conejo-garcía
Current Medicinal Chemistry, 2008
View PDFchevron_right
2,6,9-trisubstituted purines : Optimization towards highly potent and selective CDK1 inhibitors
Patricia Imbach , Pascal Furet
Bioorganic & Medicinal Chemistry Letters, 1999
View PDFchevron_right
A convenient synthesis and molecular modeling study of novel purine and pyrimidine derivatives as CDK2/cyclin A3 inhibitors
Heba Elzahabi
Bioorganic & Medicinal Chemistry, 2010
View PDFchevron_right
Cyclin-dependent kinase (CDK) inhibitors: development of a general strategy for the construction of 2,6,9-trisubstituted purine libraries. Part 2
David Grierson
Tetrahedron Letters, 2001
View PDFchevron_right
Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors
Lutz Preu
European Journal of Pharmaceutics and Biopharmaceutics, 2017
View PDFchevron_right
ANTITUMOR ACTIVITY OF SOME NEW 1,3,8TRISUBSTITUTED PURINE-2,6-DIONES AND 1,3,6TRISUBSTITUTED THIAZOLO[2,3-f]PURINE-2,4DIONES
Alaa Hayallah
Bulletin of Pharmaceutical Sciences. Assiut
View PDFchevron_right
45 A convenient synthesis and molecular modeling study of novel purine and pyrimidine derivatives as CDK2/cyclin A3 inhibitors
Abdel-Sattar S. Hamad Elgazwy
View PDFchevron_right
Synthesis of Novel 2,9-Disubstituted-6-morpholino Purine Derivatives Assisted by Virtual Screening and Modelling of Class I PI3K Isoforms
Ashly Rocha , Maria Casadei
Polymers
View PDFchevron_right
Synthesis of novel substituted purine derivatives and identification of the cell death mechanism
Zeynep Demir
European Journal of Medicinal Chemistry, 2015
View PDFchevron_right
Novel N9-arenethenyl purines as potent dual Src/Abl tyrosine kinase inhibitors
Raji Sundaramoorthi
Bioorganic & Medicinal Chemistry Letters, 2008
View PDFchevron_right