β Cells led astray by transcription factors and the company they keep (original) (raw)

Pancreatic β cell identity requires continual repression of non-β cell programs

Vincenzo Cirulli

The Journal of clinical investigation, 2017

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Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming

anil bhushan

Genes & Development, 2011

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LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells

maike sander

The Journal of clinical investigation, 2017

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The transcription factors Nkx6. 1 and Nkx6. 2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells

maike sander

Development, 2007

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Islet-1 Is essential for pancreatic β-cell function

Jonathan Schug

Diabetes, 2014

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Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity

Mark A Magnuson

PLoS Genetics, 2013

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Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells

maike sander

Cell Reports, 2013

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Role of transcription factors in the transdifferentiation of pancreatic islet cells

Talitha van der Meulen

Journal of molecular endocrinology, 2015

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PAX4 Defines an Expandable β-Cell Subpopulation in the Adult Pancreatic Islet

Bernat Soria, Petra Isabel Lorenzo, Thierry BRUN

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PDX-1 Function is Specifically Required in Embryonic Β cells to Generate Appropriate Numbers of Endocrine Cell Types and Maintain Glucose Homeostasis

Mark A Magnuson

Developmental Biology, 2008

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PAX6 maintains β cell identity by repressing genes of alternative islet cell types

Ruth Ashery-Padan

The Journal of clinical investigation, 2017

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The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic β-cell differentiation

Lori Sussel, Beatriz Pineda

Developmental Biology, 2004

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EndoC-βH1 multi-genomic profiling defines gene regulatory programs governing human pancreatic β cell identity and function

Arushi Varshney

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The pancreatic β-cell: birth, life and death

James Shaw

Biochemical Society Transactions, 2008

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NKX6 transcription factor activity is required for - and -cell development in the pancreas

maike sander

Development, 2005

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Transcription factors direct the development and function of pancreatic β cells

Swarup K Chakrabarti

Trends in Endocrinology & Metabolism, 2003

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Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets

Alex M

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NKX6.1 Promotes PDX-1-Induced Liver to Pancreatic β-Cells Reprogramming

Eytan Mor

Cellular Reprogramming (Formerly "Cloning and Stem Cells"), 2010

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Defining a Novel Role for the Pdx1 Transcription Factor in Islet β-Cell Maturation and Proliferation During Weaning

Mark A Magnuson

Diabetes, 2017

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Stage-specific transcriptomic changes in pancreatic α-cells after massive β-cell loss

Agustín Romero

BMC Genomics, 2021

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Chronic Hyperglycemia Triggers Loss of Pancreatic β Cell Differentiation in an Animal Model of Diabetes

Jean-christophe Jonas

Journal of Biological Chemistry, 1999

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Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx

Pedro Herrera

Cell metabolism, 2017

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The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells

D. Lu, Jonathan Schisler

Proceedings of the National Academy of Sciences, 2005

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Upregulation of insulin receptor substrate-2 in pancreatic β cells prevents diabetes

Rohit Kulkarni

Journal of Clinical Investigation, 2003

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Chronic Hyperglycemia Triggers Loss of Pancreatic beta Cell Differentiation in an Animal Model of Diabetes

Wendy Hasenkamp, Jean-christophe Jonas

Journal of Biological Chemistry, 1999

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Pancreatic transcription factors and their role in the birth, life and survival of the pancreatic β cell

Colin Hay

Molecular and Cellular Endocrinology, 2008

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The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice

Klaus Kaestner

2009

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PDX1 is the cornerstone of pancreatic β-cell functions and identity

Nour Ebrahim

Frontiers in Molecular Biosciences, 2022

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What is a β cell? – Chapter I in the Human Islet Research Network (HIRN) review series

Ronald Gill

Molecular metabolism, 2021

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Pancreatic β Cells Require NeuroD to Achieve and Maintain Functional Maturity

Pedro Herrera

Cell Metabolism, 2010

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