AT1R inhibitor losartan does not attenuate LPS-induced cardiac fibrosis (original) (raw)
2013
Abstract
<p>Percent collagen fraction area in the left ventricle by picrosirius red staining (mean+SEM, n = 5) increased with LPS (P<0.001, 2 way ANOVA). LPS effects were not affected when the AT<sub>1</sub>R inhibitor losartan was added to the drinking water (P = 0.80). Losartan alone had no effect. There was no significant interaction between LPS and losartan (P = 0.70).</p
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