Kyron T-114 as an effective Precursor for development of fixed dose combination Orodispersible Formulation using taste masked Resinate (original) (raw)

International Journal of Drug Development & Research

The objective of the present work was to develop taste masked fixed dose combination orodispersible tablet of dextromethorphan HBr (DXM), chlorpheniramine maleate (CPM) and phenylephrine HCl (PHE) using polymer (Eudragit E-100) and various grades of ion exchange resins (Kyron® and Tulsion®). The taste masking agents were explored for their effectiveness by investing drugs in ratios of 1:1, 1:2 and 1:3, with taste masking agents and coded as DS1 – DS18. After the evaluation for taste masking drug: Kyron T-114 (1: 3; DS6) was found as an effectively taste masked resinate and was optimized, evaluated for pharmacotechnical parameters, and characterized by diffuse reflectance spectroscopy, differential scanning calorimetry and surface morphology. DS6 was formulated as orodispersible tablets by direct compression and official and unofficial tests and orodispersion characteristics were evaluated. Resinate DS6 of DXM, CPM and PHE with Kyron T-114 in the ratio of 1:3 successfully masked the ...