Diffusing Capacity for Carbon Monoxide (DLCO): Association with long-term outcomes after Lung Transplantation in a 20-year longitudinal study (original) (raw)

European Respiratory Journal, 2021

Abstract

RationaleThe diffusing capacity for carbon monoxide corrected for haemoglobin (DLCOcor), measures gas movement across the alveolar-capillary interface. We hypothesised that DLCOcor is a sensitive measure of injurious allograft processes disrupting this interface.ObjectivesTo determine the prognostic significance of the DLCOcor trajectory on chronic lung allograft dysfunction (CLAD) and survival.MethodsA retrospective analysis was conducted of all bilateral lung transplant recipients at a single centre, between Jan-1998 and Jan-2018, with ≥1 DLCOcor measurements. Low baseline DLCOcor was defined as the failure to achieve a DLCOcor >75% predicted. Drops in DLCOcor were defined as >15% below recent baseline.Results1259/1492 lung transplant recipients were included. The median time to peak DLCOcor was 354 (range 181–737) days and the mean %-predicted DLCOcor was 80.2% (sd 21.2). Multivariable analysis demonstrated that low baseline DLCOcor was significantly associated with death (...

Michael Hutcheon hasn't uploaded this paper.

Let Michael know you want this paper to be uploaded.

Ask for this paper to be uploaded.