Inorganic Chemistry Communications (original) (raw)
The syn the sis and char ac ter iza tion of new co or di na tion com pounds of some organotin(IV) chlo rides with fexofenadine are re ported; the ligand mol e cules ap pear to be bound to the tin atom through car bonyl ox y gen atom. The struc ture of the syn the sized com pounds has been char ac ter ized by el e men tal anal y ses, and bond ing in these complexes is dis cussed in terms of their IR, 1 H NMR and through Mössbauer stud ies. The spec tro scopic re sults ob tained are in full agree ment with the pro posed 1:1 stoichiometry. The syn the sized com plexes have been screened for anti-in flam ma tory ef fect. The re sults ob tained showed that triphenyltin(IV) de riv a tives of fexofenadine ex hib ited prom is ing anti-in flam ma tory ef fect as com pared to the other tin(IV) de riv a tives of the same ligand. IN OR GANIC CHEM IS TRY carboxylate lig ands and es tab lished their bioactivities . Given the phar ma colog i cal im por tance of fexofenadine and the po ten tial bi o log i cal ac tiv ity of organotin carboxylates, it was thought of some in ter est to ex plore the chem is try of organotin/ fexofenadine com pounds. We re port here the syn the sis and spec tral char ac ter iza tion of [R 3 SnL] (where R = Me (1), Et (2), n-Bu (3), Ph (4), benzyl (5), and L is deprotonated fexofenadine).
A bst ra ct : T ra ns iti o n me t al c o mp le x e s ha ve be e n e x pl oi t e d e x te ns i ve l y t o de sig n ne w d r ugs d ue t o t he i r f avo ra b le e le c t ro nic e nv i ro n me nt a nd t una bl e ge o me t ry. T he se s pe c i f ic p rope rt ie s ha ve p ro v e d t o be adv a nt ag e o us f o r t he i r ve rs at ile bi ol og ic al ap pl ic ati o ns. He re i n, we are f oc us i ng o n s y nt he si s of t wo e ste r b ase d ox ova na di u m c om ple x e s , say, bis( b ut ano ic ac id-3 -ox o-1, 1di m e t hy le t hy le ste r) ox ov ana d i um(I V ) (1) a nd bis (d ip rop a n-2 -yl-p rop a ne di oa te )ox o v ana di um (I V ) ( 2). C o mp le x es we re c ha ra c te ri ze d b y UV s pe c t ro sc o py, FT I R st ud ie s and M ass s pe c t ro sc o pic anal ys is. T he c o mp le x e s a re asse sse d f o r c he mic al nuc le ase ac t i vi t y ag ai nst p la s mid p B R3 2 2 usi ng g el e l e c t rop ho re si s. Furt he r s up p o rt t owa rds bi ndi ng mo de i s ca r rie d o ut b y UV t i t ra ti o n usi ng c al f t hy mus D NA. Doc ki ng st udie s a re d o ne t o c o mpa re e x pe ri me nta l a nd t heo re ti c al re s ul ts. K e y wo rds : Ox o va na di um c o mpl e xe s, DN A b i ndi ng , nucl e ase act i vit y, doc ki ng. A bst ra ct : W ol la st o nite ( Ca SiO 3 ) ha s re c e i ve d its c onsi de r ati o n i n t he f i e l d of ha rd t iss ue e ng i ne e ri ng d ue t o it s go o d bi o act i vi ty a nd bi oc o mp at ib ili t y. I n t he pr e se nt st ud y, Wo ll ast o nite wa s p re p are d b y s ol -g e l c om busti o n me t ho d b y usi ng t a rt a ric ac id a s a f ue l f or t he fi rs t t i me . C al c i um ni t rat e a nd t e t rae t hy l o rt hos il i cate we re t a ke n as t he s ourc e of c alc i u m a nd si l ic a te . T he obt a i ne d pro d uc t wa s c ha ra c te ri se d by F T-I R s pec t ro sc op y t o ide nti fy t he c ha r act e ri st ic f unc ti o na l g ro up s pre se nt i n t he m at e ri al a nd po wde r X -Ra y dif f rac ti o n te c hni q ue f or t he p ha se i de nti fi c at i o n. T he SE M i mag e re ve al s t hat t he mo rp hol og y of W ol l ast o nite whic h wa s i r re g ul ar i n s ha pe a nd p a rt ic le s a re ho mog e ne o us i n s i ze .
6.10a. Inorg. Chem. 31,1233.pdf
The ruthenium complex [Ru2(CloHsN2)(CO),(PiPr3),] (1) (CloHIoN2 = 1,8-diaminonaphthalene) reacts with 1 equiv of HgX, (X = C1, Br, I, 02CCH,, 02CPh, 02CCH2C1, 02CCF3, SCN, ONC) to give the adducts [(1)HgX2], in which the Hg atoms are bonded to both Ru atoms of complex 1. Correlations between the 2J(3'P-199Hg) coupling constants of their 31P NMR spectra and the corresponding halogen electronegativities or acid pK,s have been observed. With the exception of [(1)Hg(O2CCF,),], which does not react with any other mercury(I1) salt, the compounds [(l)HgX,] react with HgX', (X' = C1, Br, I, 02CCH3, 02CPh, 02CCH2C1) to give the insertion products [(l)Hg(p-X'),HgX,] only when X' is more electron-withdrawing than X; otherwise, the addition products [(l)Hg(pX),HgX',] are formed. All reactions of [(l)HgX,] with Hg(02CCF3), give the same substitution product [(l)Hg(02CCF3)2]. The molecular structures of [(l)Hg(O,CCF,),] and [(l)Hg(p-Cl),HgCI,] have been confirmed by X-ray crystallography. [(l)Hg(O,CCF,),]: monoclinic, space group C2/c, a = 23.730 (9) A, b = 12.578 (4) A, c = 14.51 1 (7) A, fl = 94.76 (5)O, Z = 4. [(1)Hg(p-C1),HgC1,]~CH2Cl2: monoclinic, space group P 2 , / n , a = 15.840 (7) A, b = 12.694 (4) A, c = 23.366 (2) A, fl = 105.74 (2)O, Z = 4. Cabeza, J. A.; Fernindez-Colinas, J. M.; Riera, V.; Garda-Granda, S.; Van Der Maelen, J. F. Inorg. Chim. Acta 1991, 185, 187. Cabeza, J. A.; Fernindez-Colinas, J. M.; Riera, V.; Pellinghelli, M. A.; Tiripicchio, A. J. Chem. Soc., Dalton Trans. 1991, 371. Andreu, P. L.; Cabeza, J. A.; Riera, V.; Robert, F.; Jeannin, Y. J. Organomet. Chem. 1989, 372, C15. Oro, L. A.; Fernindez, M. J.; Modrego, J.; Foces-Foces, C.; Cano, F. H. Angew. Chem., Inr. Ed. Engl. 1984, 23, 913. Fernindez, M. J.; Modrego, J.; Oro, L. A.; Apreda, M. C.; Cano, F. H.; Foces-Foces, C. J. Chem. SOC., Dalton Trans. 1989, 1249. See, for example: Panizo, M.; Cano, M. J. Organomet. Chem. 1984, 266,247. Pardo, M. P.; Cano, M. J. Organomet. Chem. 1983,247,293. Faraone, F.; Lo Schiavo, S.; Bruno, G.; Bombieri, G. J. Chem. Soc., Chem. Commun. 1984, 6. (a) Ermer, S.; King, K.; Rosenberg, E.; Manotti-Lanfredi, A. M.; Tiripicchio, A.; Tiripicchio-Camellini, M. Inorg. Chem. 1983, 22, 1339. (b) Rosenberg, E.; Ryckman, D.; Hsu, I.-N.; Gellert, R. W. Inorg. Chem. 1986, 25, 194. (c) Rosenberg, E.; Hardcastle, K. I.; Day, M. W.; Gobetto, R.; Hajela, S.; Muftikian, R. Organometallics 1991, 10, 203. (d) Fadel, S.; Deutcher, J.; Ziegler, M. L. Angew. Chem., Int. Ed. Engl. 1977, 16, 704. (e) Fajardo, M.; Holden, H. D.; Johnson, B. F. G.; Lewis, J.; Raithby, P. R. J. Chem. SOC., Chem. Commun., 1984, 24. (f) G6mez-Sa1, M. P.; Johnson, B. F. G.; Lewis, J.; Raithby, P. R.; Syed-Mustaffa, S. N. A. B.
Organometallic 1998, 17, 4259-4262.pdf
The crystal structure of di-n-butyltin pyridine-2-phosphonate-6-carboxylate, [C 14 H 24 NO 6 -PSn] 2 , features centrosymmetric dimers disposed about a central Sn 2 O 2 core. The phosphonate carboxylate dianion is µ 2 -tetradentate, coordinating one tin atom via one of the phosphonate oxygen atoms, the pyridine nitrogen atom, and one of the carboxylate oxygen atoms; the latter atom also coordinates the second tin atom of the dimer. The remaining positions in the seven-coordinate, distorted pentagonal bipyramidal geometry are occupied by a water molecule and two n-butyl groups that occupy axial positions. The lattice is stabilized by hydrogen-bonding contacts leading to an arrangement of parallel, orthogonally related chains of dimeric units. In methanol solution, the dimer is involved in a dissociation equilibrium that is fast on the NMR time scale. (1) (a) Gielen, M.; Joosen, E.; Mancilla, T.; Jurkschat, K.; Willem, R.; Roobol, C.; Bernheim, J.; Atassi, G.; Huber, F.; Hoffmann, E.; Preut, H.; Mahieu, B. Main Group Met. Chem. 1987, 10, 147. (b) Gielen, M.; Acheddad, M.; Bouâ lam, M.; Biesemans, M.; Willem, R. Bull. Soc. Chim. Belg. 1991, 100, 743. (c) Gielen, M.; Acheddad, M.; Mahieu, M.; Willem, R. Main Group Met. Chem. 1991, 14, 73. (d) Willem, R.; Biesemans, M.; Bouâ lam, M.; Delmotte, A.; El Khloufi, A.; Gielen, M. Appl. Organomet. Chem. 1993, 7, 311. (2) (a) Huber, F.; Preut, H.; Hoffmann, E.; Gielen, M. Acta Crystallogr. 1989, C45, 51. (b) Gielen, M.; Acheddad, M.; Tiekink, E. R. T.
Chemical Society 132(49): 17411-17425
2016
Neutralizing positive charges at the surface of a protein lowers its rate of amide hydrogen exchange without altering its structure or increasing its thermostability (Article begins on next page) The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters.