Facile Synthesis of Some Novel Tetrasubstituted 2,4-Diaminopyrimidine Derivatives in Aqueous Glucose Solution as a Fully Green Medium and Promoter (original) (raw)
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Green synthesis and Biological Evaluation of Pyrimidine Derivatives.pdf
A study was carried out on the amination of substituted-4-chloro-pyrimidine under conventional and microwave conditions in presence of bis (dibenzylideneacetone) palladium (0) (Pd(dba)2) as a metal ligand catalyst and xantphos which acts as a bidentate ligand. The reaction of 2-amino-4-chloro-6- methylpyrimidine with aromatic and aliphatic amines in presence of a catalyst gives 2-Amino-6-subsituted-pyrimidine derivatives. The reactions were studied under microwave irradiation showed moderately better results when compared to conventional method. The compounds were screened for their antimicrobial activity against pathogenic strains such as S.aureus, E.coli, K. aerogenes, A. flavus and C. albicans and anthelmintic activity conducted using P. posthuma (Indian Earthworm). Among the synthesized compounds 6a, 6c & 6f have shown significant antibacterial activity.
An efficient one-pot multi component synthesis of pyrimidine derivatives in aqueous media
Archives of Applied …, 2012
A simple and efficient synthesis of aryl and heteroaryl substituted pyrimidines has been developed via initial Knoevenagal, subsequent addition and final cyclization of aldehyde, ethylcyanoacetate and guanidine nitrate. Piperidine has been used as a catalyst. Short reaction time, environment friendly procedure and excellent yields are the advantages of this procedure. All synthesized compounds were characterized by IR, NMR and Mass spectral data.
International Journal of Organic Chemistry, 2012
A series of pyrido[2,3-d]pyrimidines derivatives have been prepared by one-pot three-component reaction of 4(6)aminouracil, malononitrile and aromatic aldehydes. This efficient synthesis was done under microwave irradiation conditions (method A) and also using catalytic amount of diammonium hydrogen phosphate [(NH 4) 2 HPO 4 ] (DAHP) in aqueous media (method B). This procedure has the advantages of good yields, easy work-up, and benign environmentally friendly character. Reaction could proceed via domino Knoevenagel-Michael-cyclization reactions.
Proficient synthesis of bioactive annulated pyrimidine derivatives: A review
Journal of Taibah University for Science
Syntheses of bioactive annulated pyrimidine derivatives are the most significant tasks in N-heterocyclic chemistry because these compounds have proved to be very attractive and useful for the design of new molecular frameworks of potential drugs with varying pharmacological activities. This review paper summarizes the one-pot multicomponent synthesis of annulated nitrogen-and oxygencontaining heterocycles, such as pyrano[2,3-d]pyrimidines, pyrido[2,3-d]pyrimidines and pyrido[2,3-d;5-6-d]dipyrimidines. The synthetic procedure is based on the chemistry of the domino Knoevenagel-Michael addition mechanism.
In this study, twenty-nine 2-aminopyrimidine derivatives are synthesized in good to excellent yields by fusing 2-amino-4,6-dichloropyrimidine with different amines in the presence of triethylamine without using any solvent or catalyst. Nucleophilic substitution reactions of 2-amino-4,6-dichloropyrimidine with amines have also been performed in ethanol. Comparisons of the yields and reaction times for both solvent and solvent-free conditions have shown that the newly developed solvent-free protocol is high yielding, more efficient, and simpler compared to conventional methods.
One-pot, three-component Synthesis of pyrrolo[2,3-d]pyrimidine Derivatives
A green approach for the synthesis of polyfunctionalized pyrrolo[2,3-d]pyrimidine derivatives was successfully achieved by a one-pot three-component reaction of arylglyoxals, 6-amino-1,3-dimethyluracil and barbituric acid derivatives in the presence of tetra-n-butylammonium bromide (TBAB) (5 mol%) as the catalyst in ethanol at 50 °C. This protocol has many advantages such as high yields (73-95%), green and simple procedure, short reaction times, easy work-up, mild reaction conditions and general applicability.
Macromolecular Symposia, 2019
A clean and ecofriendly approach for the catalyst‐free synthesis of pyrido[2,3‐d]pyrimidine derivatives by one‐pot three‐component condensation of aromatic aldehyde, malononitrile and 6‐aminouracil or 6‐amino‐1,3‐dimethyluracil using glycerol–water (3:1) as green reaction media has been developed. Catalyst‐free synthesis with high to excellent yields and use of glycerol–water system as an environmentally benign reaction condition are the prominent features of this strategy. Moreover, excellent outcomes from the calculations of green chemistry metrics reveal the greenness of the protocol.
A New Multicomponent Synthetic Route to Hexahydropyrido[2,3-d ]pyrimidine Derivatives
Journal of Heterocyclic Chemistry, 2019
A new one-pot multicomponent reaction of equimolar amounts of malononitrile and benzaldehyde in ethanol for the synthesis of hexahydropyrido[2,3-d]pyrimidine derivatives through a sequence of Knoevenagel condensation, Michael addition, and Addition of Nucleophile, Ring Opening, and Ring Closure process is described.