Association Of Vitamin D Status And Diabetes Mellitus (original) (raw)
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Indian journal of endocrinology and metabolism, 2014
Vitamin D deficiency (VDD) has been linked to impaired glucose tolerance and type 2 diabetes (T2D) in humans. The aim of the present study was to find the vitamin D status in newly detected T2D patients compared with healthy controls. One hundred and two, newly detected T2D patients and similar number of age, body mass index (BMI), and gender matched healthy controls without diabetes were studied. In addition to basic information, metabolic parameters and serum 25 hydroxy vitamin D (25HD) were measured in both the groups. Overall 25HD, was lower (mean ± SD, 18.81 ± 15.18 ng/ml) in patients with T2D as compared to healthy controls (28.46 ± 18.89 ng/ml) (P = 0.00). Taking a cut of 30 ng/ml, 81% of T2D patients had either VDD or insufficiency compared to 67% of healthy control subjects. Severe VDD (25HD of < 5 ng/ml) was seen in 16.2% of patients with diabetes and 2.5% of control subjects. Levels of 25HD had a negative correlation with HbA1c, fasting plasma glucose. VDD is common in...
Iranian journal of diabetes and obesity, 2020
Objective: It has been explored that Vitamin D play role in various non-skeletal disorders including Diabetes Mellitus. The present study was designed with the aim to assess association among control, pre-diabetic and diabetic with vitamin D and association between lipid profile and vitamin D. Materials and Methods: A total of 109 subjects were recruited for the cross-sectional study including 37 as control, 41 pre-diabetic and 31 diabetic. A clinical examination was done for all the groups including fasting samples (12hrs) for lipid parameters, serum 25 (OH) vitamin D level and (HbA1/C). Results: It was found that in control subjects 37.9% have the sufficient vitamin D3 level whereas 17.1% subjects in pre-diabetic, 16.6% in diabetic with good glycemic control and no subject was found to have sufficient vitamin D3 level in diabetic with poor glycemic control. The mean vitamin D3 levels was highest in control i.e. -26.53±11.99 ng/ml followed by 20.23±4.12ng/ml in prediabetics,19.07±8...
Serum 25-Hydroxy Vitamin D levels in Type 2 Diabetes Mellitus-A Comparative study
Innovative publication, 2016
Background: Type 2 diabetes mellitus (DM) is a disease of impaired carbohydrate metabolism. Vitamin D deiciency and diabetes mellitus are two common conditions and they are widely prevalent across all ages, races, geographical regions, and socioeconomic conditions. The present study aimed to see the effect of 25 hydroxy (OH) vitamin D levels on glycemic control and to show their role in pathogenesis. Materials and Methods: It was a case control study. The study included 100 cases of clinically diagnosed type 2 DM and 100 age and sex matched healthy controls. Venous blood sample was analysed for fasting blood sugar(FBS), post prandial blood sugar (PPBS), serum 25-OH vitamin D and glycosylated hemoglobin(HbA1c) in both cases and controls. Statistical analysis was done using student't' test. Pearson's correlation was performed to establish the relationship between study variables. Results: There was decreased levels of serum 25-OH vitamin D levels (p<0.001) in cases as compared to the controls. There was negative correlation between 25-OH vitamin D levels and glycosylated hemoglobin (HbA1c) in cases of type 2 DM. Conclusion: 25-OH Vitamin D levels were lower in patients of type 2 DM as compared to control group. Early detection of vitamin D deficiency and supplementation may help in improvement of glycemic control and prevent complications.
International Journal of Basic and Clinical Pharmacology, 2015
Vitamin D deficiency, as reflected by circulating 25-hydroxyvitamin D (25[OH]D) levels <20 ng/ml, is prevalent in as many as one-half of middle-aged to elderly adults in developed countries. 1,2 The ubiquitous distribution of Vitamin D receptors in the body, controlled by nearly 3000 genes, 3,4 suggest that a deficiency could have widespread health consequences. Thus, understanding the characteristics that promote Vitamin D deficiency in the general population has important clinical implications. Vitamin D deficiency is estimated to affect over 1 billion people worldwide, 1 and its prevalence is increasing in conjunction with Type 2 diabetes (T2D), obesity, and derangements in metabolic traits. Recent studies have examined the physiological functions of Vitamin D beyond its well-established role in musculoskeletal health. 5 In addition to findings of oncologic 4 and immunologic 5 associations, Vitamin D deficiency is associated with metabolic derangements and T2D. 6-8 Although 1, 25(OH)D is the active form of Vitamin D, it is not suitable for measuring Vitamin D serum level. 25(OH)D has a longer half-life and it can more precisely show the food intake and skin production of Vitamin D. A serum level of <20 ng/ml (50 nmol/L) 25(OH)D is considered as Vitamin D deficiency, between 20 and 30 ng/ml as its insufficient level and higher than 30 ng/ml as its desirable or sufficient level. 9-11
Spectrum of Vitamin D in Type 2 Diabetes Mellitus: A Hospital Based Study
Journal of Evidence Based Medicine and Healthcare, 2018
BACKGROUND Vitamin D deficiency has been found to have an inverse relationship with the occurrence of type-2 diabetes mellitus. The aim of this study was to assess serum vitamin D level in patients with type 2 DM and correlate its finding with healthy controls, and to ascertain the relationship between low 25(OH) vitamin D levels and the marker of glycemic control, glycated hemoglobin A1c (HbA1c). MATERIALS AND METHODS Total 100 patients of type 2 diabetes mellitus were selected as cases with an equal number of non-diabetic persons without chronic renal failure, coronary artery disease, chronic liver disease, patients not on calcium and vitamin D supplementation were taken as controls. Serum 25 hydroxyvitamin D3 level was estimated and compared with fasting blood glucose and glycosylated HbA1C in both the cases and controls.
A Study on Vitamin D Levels in Patients with Type II Diabetes compared to Normal Subjects
2015
Vitamin D deficiency is highly prevalent in the world and in Asian countries including Iran. There is a great deal of evidence suggesting the relationship between serum Vitamin D level and prevalence of type II diabetes. The objective of this study was to assess the serum level of Vit D in diabetics and non-diabetics and to compare the results of the two groups. This descriptive epidemiological study was carried out on 79 participants including 40 diabetic patients and 39 healthy individuals. The participants were randomly selected from the participants of the Ahwaz Metabolic Syndrome project. The serum vitamin D level, FBS, PTH, and insulin level were measured in the participants. The insulin resistance (HOMA-IR index) was also calculated for all participants. In general, 97.1% of healthy participants and 88.1% of diabetics were diagnosed with vitamin D deficiency or inadequacy. No difference was observed between the levels of vitamin D in the two groups (P=0.23). There was a stati...
Evaluation of Serum 25-Hydroxyvitamin D Levels in Type 2 Diabetes Mellitus Patients
https://www.ijhsr.org/IJHSR\_Vol.7\_Issue.2\_Feb2017/IJHSR\_Abstract.022.html, 2017
Background: Vitamin D plays an important role in calcium metabolism and vitamin D deficiency may be associated with a range of diseases, including cardiovascular disease and type 2 diabetes and has been associated with impaired insulin action, through direct effect of vitamin D on the β-cell function. Aim: To evaluate serum 25-Hydroxy vitamin D levels in type 2 diabetes mellitus patients. Materials And Methods: The study was conducted on 45 diagnosed type 2 Diabetes mellitus patients and 25 non-diabetic age and gender matched control in the Department of Biochemistry, Government Medical College Patiala sample was collected in plain vial and serum25-hydroxy vitamin D levels were evaluated by ELISA technique and the results were statistically analysed. Results: The Mean values of serum 25-hydroxyvitamin D levels in study group and control group were 16.31± 14.03 and 26.63 ± 16.54 respectively (Normal Value of vitamin D =30-74 ng/ml).The decrease in Vitamin D levels in study group as compared to control group shows statistically significant association(p value< 0.07). Conclusions: Vitamin D levels appeared to be lower in diabetes mellitus type 2 patients than in the control group. These findings may have therapeutic implications as cautious vitamin D supplementation may improve glycemic control in diabetes mellitus type 2.
Serum 25-hydroxy vitamin D level in diabetic patients versus normal individuals; a pilot study
Journal of Parathyroid Disease, 2016
Introduction: Vitamin D deficiency is a common health problem throughout the world. There is growing interest in vitamin D status as a potentially adjustable risk factor for diabetes mellitus. Objectives: The main aim of this investigation is to assess, the possible differences of vitamin D serum value of diabetics versus normal persons. Patients and Methods: This study was a cross-sectional investigation was conducted on 106 persons (females; 44, males; 62) consisting of 75 subjects, were free of any diseases who had normal fasting blood sugar (FBS) and 31 type 2 diabetic patients. Blood level of 25-hydroxy vitamin D [25(OH) D] was FBS, 2-hour postprandial blood sugar (2-h PPBS), calcium, creatinine, and uric acid were measured using standard kits. The independent t test was used to determine the significance of any baseline differences between groups and Pearson correlation test was used to assess correlations by STATA software version 12. Results: The mean serum 25(OH) D concentr...
Assessment of Vitamin D Deficiency in Type 2 Diabetes Mellitus Patients
JOURNAL OF HEALTHCARE IN DEVELOPING COUNTRIES, 2020
Aim: To assess vitamin D deficiency in type 2 diabetes mellitus patients. Materials & Methods: Eighty- two type 2 diabetes mellitus patients of either gender and equal number of healthy controls were also enrolled. 25(OH)D level was estimated by chemiluminescence immunoassay (CLIA). Normal serum 25 (OH)D level was defined as 30 ng/ml or more. Vitamin D insufficiency state was defined at a level of 21 – 29 ng/ml. Vitamin D deficiency state was defined at a level of 20 ng/ml or less. Severe vitamin D deficiency was defined as < 10 ng/ml. Results: There were 35 severely deficient, 20 deficient, 12 insufficient and 15 normal patients in group 1 and 2 severely deficient, 4 deficient, 8 insufficient and 8 normal subjects in group 2. Conclusion: Type II DM patients had severe vitamin D deficiency as compared to healthy control subjects.
International Journal of Research in Medical Sciences
Prediabetes broadly refers to an intermediate stage between normal glucose levels and the clinical entity of type 2 diabetes, encompassing both impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). 1 The progression from prediabetes to type 2 diabetes occurs over many years before the development of overt hyperglycemia seen in diabetes. 2 The risk of progression to diabetes depends on the degree of insulin resistance and deficiency of Insulin secretion and other risk factors ABSTRACT Background: Role of vitamin D in the regulation of calcium metabolism is well established. Vitamin D deficiency has been linked to impaired glucose tolerance and type 2 DM in humans. There is a limited available data on the relationship of vitamin D insufficiency/deficiency with glucose homeostasis among prediabetic individuals in South Indian population. Hence we examined serum 25(OH) D 3 concentration among prediabetics. The objective of this study is to evaluate prevalence of vitamin D deficiency in prediabetics and to study any correlation between vitamin D and BMI, FBS and PPBS among prediabetics. Methods: A case control study was carried out among 40 prediabetics & controls, after obtaining consent from subjects and clearance from institutional ethics committee. Serum vitamin D levels were measured by radioimmunoassay in both groups. Statistical analysis was done using "t" test & Pearson correlation coefficient (r). Results: Vitamin D levels less than 20 ng/ml were found in 72.5% of cases and 35% of controls. 5% of the cases and 12.5% of the controls had vitamin D above 30 ng/ml and this difference was statistically significant. Mean vitamin D levels in cases and controls was 17.09±5.89 ng/ml and 23.67±11.02 ng/ml respectively (P<0.05). A significant inverse correlation was observed between vitamin D levels & body mass index (r=-0.274; p=0.014); random blood sugar (r=-0.35; p=0.001); fasting blood sugar (r=-0.328; p=0.003); post prandial blood sugar (r=-0.276; p=0.013). Conclusions: High prevalence of hypovitaminosis D exists among prediabetics and there is significant inverse correlation between BMI, FBS, PPBS and vitamin D levels. Hence, a prospective study covering large pre-diabetic individuals is essential to confirm the findings.