Salivary IgA responses to oral microorganisms in newborn (original) (raw)

Abstract

Objectives: Analysis of the mucosal immune system represents an interesting way to understand the microbial colonization in early life, particularly the response of salivary IgA. Previous study showed in children with 6 months of age, a high complexity of SIgA response to antigens (Ags) of mutans streptococcal (MS), but little is known about the ontogeny of the mucosal immune system in the first 3 months of life especially in preterm (PT, < 37 weeks). We compared the levels and specificity of SIgA to MS and others species enrolled with initial infection in fullterm (FT) and PT early in life. Methods: Stimulate saliva from 160 children, with 0 day of life and after 3 months, were enrolled in this study. Salivary IgA and IgM levels were determined by ELISA. Subsets of 24 FT and 24 PT showing similar salivary IgA levels were paired. SIgA antibody reactivity to MS, S. sanguinis (SSA), S.mitis (SMI) and S.gordonii (SGO) Ags was determined in Western blot assays. Results: Levels of SIg...

Virginia Ferriani hasn't uploaded this paper.

Let Virginia know you want this paper to be uploaded.

Ask for this paper to be uploaded.