Evaluation of Counter Irritant Potential of Aqueos Bark Extract of Cinnmon Loureiroi (original) (raw)
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EVALUATION OF ANTIEMETIC POTENTIAL OF AQUEOUS BARK EXTRACT OF CINNAMON LOUREIROI
Crude aqueous bark extract of Cinnamon loureiroi. was evaluated for anti-emetic potential. Emesis was induced by the oral administration of copper sulphate and fresh aqueous extract of Brassica compestris to male chicks of fifteen days age. The anti-emetic activity was determined by calculating the mean decrease in number of retching in contrast with those of control. Cinnamon (3 and 6 mg / kg body weight orally) showed anti-emetic activity when compared with standard drugs Chlorpromazine , Domperidone and Metoclopramide. Both the extracts, showed the antiemetic activity, highest (79.22% inhibition) and the lowest (58. 94 % inhibition) in copper sulphate induced emesis and highest (81.91% ) and the lowest( 59.57%) in Brassica compestris induced emesis .
Toxicology Reports, 2019
Cymbopogon citratus has been used by the local people in Ankober district, northern Ethiopia, as traditional medicine to treat various ailments. Its essential oil has been shown to have antibacterial, antifungal, antiprotozoal, anti-carcinogenic, anti-inflammatory and antioxidant activities amongst others. This study was conducted to determine skin irritation, acute and subacute toxicity of C. citratus essential oil in mice and rabbits. The essential oil was analyzed using GC-MS. The essential oil at dose of 2000 mg/kg body weight was administered to mice for 21 consecutive days. The mice mortality, behavioral change, injury and other signs of illness were recorded once daily. Biochemical parameters were evaluated. Liver and kidney were taken after sacrifice for gross findings and histological analyses. 10 % ointment formulation of C. citratus oils was applied on the rabbit skin to determine skin irritation effects. The result revealed, the presence of citral (71.297%), myrcene (19.034%), 4, 5-epoxycarene (2.780%), linalool (1.713%), ((S)-cis-verbenol (1.110 %), linalool (1.713 %), ((S)cis-verbenol (1.110 %) and undecan-2-one (1.001 %) in the C. citratus essential oil. There was no significant difference (p > 0.05) in the body weights, gross abnormalities of the organs and biochemical parameters compared to the control. No histopathological changes were detected in the organs tested. 10 % ointment formulation of C. citratus oils did not cause skin irritation. Analysis of results leads to the conclusion that Ethiopian C. citratus essential oil may be considered as relatively safe and non-toxic.
Analgesic Activity of Aqueous Extract of Citrullus Lanatus Peels
The present study was undertaken to evaluate the analgesic activity of aqueous extract of Citrullus lanatus peels (AECL) using Eddy's hot plate method. The AECL produced a significant analgesic activity in a dose dependent manner. All the doses of AECL (250, 500 and 1000mg/kg) had shown analgesic activity. The reaction time obtained for these three doses after 90 minutes of drug administration was found out to be 5.15 mins, 8.92 mins and 10.82 mins respectively which was comparable to Diclofenac sodium (5 mg/kg) that showed the reaction time of 12.36 mins. It was concluded that the AECL has good analgesic potential and may be adopted as alternative to conventional NSAIDS.
Acta Amazonica, 2014
Alho do mato (Cipura paludosa, Iridaceae) is a medicinal plant found in the Amazon rain forest, North of Brazil. It has been used to treat algic, inflammatory and infectious processes. The aim of this study was to evaluate the anti-inflammatory and antinociceptive action of the crude Cipura paludosa ethanolic extract at concentrations ranging between 2.0 and 4.0% in Oil and Water cream formulations for topical use. The physical-chemical stability of the formulations was monitored over a six-month period with the use of accelerated stability tests. In order to evaluate the anti-inflammatory and antinociceptive activities, we used a paw edema test induced by carrageenan and a formalin test, respectively. The paw edema test showed that there was a statistical difference in the control group in relation to the treatments. The formalin test did not confirm antinociceptive action of the treatments with the extract in the early phase of the test. However, statistical difference was confirm...
Journal of Ethnopharmacology, 2011
Aim of the study: Caryocar coriaceum Wittm. fruit pulp fixed oil (CCFO) has been widely employed by communities from Brazil Northeastern in the treatment of skin inflammation, respiratory affections, wound healing and muscle pain. In this study, we evaluated the topical effect of CCFO against different irritant agents in vivo, in order to verify its antiedematous effect as well to unravel its tentative mechanisms of action. Materials and methods: CCFO was obtained from Caryocar coriaceum fruits using ethyl acetate as solvent. Ear edema provoked by the application of Croton oil (single and multiple applications), arachidonic acid (AA), capsaicin, phenol and histamine to Swiss mice was used to evaluate the topical anti-inflammatory effect of CCFO. Histological analysis from mice ears sensitized with Croton oil and AA single application was also performed. Results: Crude CCFO (20 L/ear) demonstrated significant topical antiedematous effect against Croton oil single (inhibition of 32.0%; P < 0.05) and multiple (41.4% after 9 days, P < 0.001) applications, AA (inhibition of 49.7%; P < 0.01) and phenol (inhibition of 38.8%; P < 0.001). In contrast, CCFO did not antagonize the edema caused by topical treatment with capsaicin and histamine when compared to control group (P > 0.05). Histological analysis also revealed that CCFO was able to reduce the edema and the influx of inflammatory cells in mice ears sensitized with Croton oil and AA. Conclusions: CCFO exhibited a similar profile of topical anti-inflammatory activity to that of drugs that classically modulate the production of arachidonic acid metabolites. The study also indicates the potential application of CCFO as an important herbal medicine to be used against skin inflammatory diseases.
Effect of Cinnamon Cinnamomum cassia Powder
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Proceedings of the 1st International Conference on Education, Humanities, Health and Agriculture, ICEHHA 2021, 3-4 June 2021, Ruteng, Flores, Indonesia, 2021
Introduction: Cinnamomum burmannii (Nees & T. Nees) Blume which has the main content of Cinnamaldehyde has an anti-inflammatory effect. Research on the antiinflammatory effect of the essential oil of the bark of C. burmannii from Kerinci Regency (CBOK) has been conducted. Methods: The anti-inflammatory test of CBOK was carried out using Wistar rats. The anti-inflammatory test was carried out by using the paw test. The volume increase in paw due to swelling were measured. Histopathological analysis was performed by counting inflammatory cells and expression of TNF-α. The data analyzed were edema volume inhibition, the number of inflammatory cells and the expression of TNF-α. Results: There was a significant difference in the increase in inhibition of edema in the administration of CBOK compared to the negative control. A decrease in the number of inflammatory cells and TNF-α expression were observed. Thus, in this study of CBOK has anti-inflammatory effects.
Assessment of Potential Toxicological Effects of Cinnamon Bark Aqueous Extract in Rats
International Journal of Bioscience, Biochemistry and Bioinformatics, 2015
Cinnamon stick is world widely used in cooking, traditional medicine, perfumery and aesthetic industries. Many studies have demonstrated the potential of cinnamon extracts in diabetes treatment. Although it has been reported as safe in general cooking recipe and categorized as GRAS by USDA, sub-acute toxicity procedure was conducted in this study to determine the effect of cinnamon extract on histopathological changes as well as the haematological parameters of blood. Water extraction was done for dried cinnamon. Twenty-four female Sprague Dawley rats were used in this study. The oral route was selected because it is the most likely route of human exposure through the consumption of herbs. The concentrations studied were 0.1, 0.5 and 2.0g/kg cinnamon aqueous extract (CE). There were no statistically significant effects of all concentrations of CE on behaviour, mortality, water intake, food consumption, weight gain, internal organs weight (liver and kidney) and heamatological parameters during treatment and post-treatment periods except: 1) the slight decreased in kidney and liver weight of rats treated with 0.5g/kg and 2) slight decreased in liver weight of rats treated with 2.0g/kg, during post-treatment period. Hence, these toxicity studies suggest that the CE is low to moderate in toxicity and CE below 0.5 g/kg dose level is safe to be used in the efficacy study especially for diabetes treatment.
Pharmacognosy Journal, 2021
Introduction: Research related to alternative medicine from natural ingredients that can relieve the effects of inflammation is important, especially to reduce the unwanted side effects of antiinflammatory drugs. Cinnamomum burmannii (Nees & T. Nees) Blume is a native Indonesian species which contains essential oils and reported for its anti-inflammatory effect. Therefore, this research was conducted to determine the metabolite profile and anti-inflammatory effect of essential oil from the bark of C. burmannii (CBO) from Lombok Timur Regency. Methods: The metabolite profile of CBO was determined using Gas Chromatography-Mass Spectra (GC-MS). The anti-inflammatory test was conducted used male Wistar rats. A total of 30 male rats were divided into 5 groups, each group consisting of 6 rats. Rats were injected with carrageenan 1%/100µl/paw which had previously been given oral CBO at a dose of 30, 60, 90 mg/kg BW. Paw swelling was measured at 1, 2, 3, 4 and 5 hours after injection. The volume of edema was measured and the animals were sacrificed. The left leg was cut and preserved as material for Hematoxylin Eosin (HE) and Immunohistochemistry (IHC) preparations. The variables taken were the percentage of inhibition edema, the number of inflammatory cells by HE and the amount of TNF-α by IHC staining. Results: The results showed that there was a difference between negative control and positive control in the number of inflammatory cells and TNF-α observed in rat's paw edema. The number was less in the positive control. Likewise, when administering CBO (60 mg/kg BW and 90 mg/kg BW) the number of inflammatory cells and TNF-α was lower than the negative control. Conclusion: It can be concluded that CBO from Lombok Timur can be used as a natural anti-inflammatory agent.
The Internet Journal of Nutrition and Wellness, 2010
Objective To study anti-inflammatory and analgesic effects of extract from the roots and leaves of Citrullus lanatus and assess their acute toxicity in animals. Methods The mouse model with ear edema induced by xylene and the rat model with paw edema or granuloma by carrageenin or cotton pellet were used for anti-inflammatory effects of the extract. Effects of the extract on analgesia was tested respectively by measuring the latency of mice licking hind foot from hot plates and by counting the times of body twisting in response to acetic acid. The acute toxicity of the extract was determined with the method of Bliss. Results The extract significantly inhibited the ear edema, granuloma hyperplasia, and paw edema. It significantly lifted the pain threshold on mouse hot-plate responses and reduced their writhing times. During the 7 d observation period in its acute toxicity assay, no apparent toxic reaction was shown and all mice survived at a dose of 87 g extract per kg body weight. Conclusion The extract could protecte mice/rates from inflammation and analgesia, and may be safe as an orally administered natural product for humans.