Endocrinology Congress 2016: Association of fasting insulin with plasma, RBC micronutrients copper and zinc in newly diagnosed type 2 diabetic patients (original) (raw)
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Study of serum copper and zinc levels in type-II diabetes mellitus patients
2021
Diabetes mellitus is one of the world’s most prevalent diseases. The International Diabetes Federation estimates a worldwide prevalence of 387 million (8.3%) and the global burden of Type-II diabetes is expected to increase 592 million by 2035. It is found that the trace elements like copper and zinc, which act as cofactors for the essential enzymes, which are involved in many metabolic pathways, are found to be altered in the diabetics when compared to non-diabetics. This is an observational, prospective and case-control study which is conducted to assess the levels of Cu and Zn in relation to hyperglycaemia and HbA1c in the patients with uncomplicated T2DM. Newly diagnosed uncomplicated Type-II Diabetes Mellitus patients are selected as study group. The observations were arranged in suitable tables for analysis under the relevant headings. The findings were averaged as (mean ± standard deviation) for each parameter subgroups separately. Each variable, including Serum levels of Cu ...
Study of Serum Zinc and Copper levels in Type 2 Diabetes Mellitus
Introduction: Diabetes Mellitus is a metabolic disease char-acterised by hyperglycemia due to defective insulin secretion or action. Levels of trace elements like Copper and Zinc have been found to be altered in this disorder. Theses might have some role in progression of this disease. Purpose of the study was to estimate serum zinc and copper levels in type 2 diabetes mellitus patients with and without micro-vascular complication and to compare with that of healthy individuals. And also, to identify the interrelationship among these. Material and methods: A cross sectional study was carried out in the Department of Biochemistry in collaboration with Department of Medicine, Regional Institute of Medical Sciences, Imphal, Manipur. Eighty randomly selected cases of confirmed type 2 diabetes mellitus (T2DM) patients diagnosed for more than one year and another forty, age and sex matched, healthy controls were included in this study. Serum copper and zinc levels were estimated colorimetrically in the serum of these patients using commercially available kit. Results: Serum Zn levels were lower for T2DM cases with complication (89.65 ± 4.21) than cases without complications (92.32 ± 5.15) and controls (95.40 ± 3.90), while serum Copper was highest among cases with complication (164.05 ± 9.32) than cases without complication (161.40 ± 6.43) and controls (131.85 ± 7.92). Conclusion: Altered levels of trace elements Zn and Cu are found to be an important predisposing factors for diabetic patients for developing complications.
International Journal of Endocrinology and Metabolism, 2016
Background: The altered levels of some essential trace elements and antioxidant minerals have been observed in diabetic patients. Objectives: The aim of the present study was to compare the concentrations of essential trace elements, copper (Cu), zinc (Zn), and iron (Fe) in the serum of patients who have type 2 diabetes mellitus (T2DM) with those of their non-diabetic first-degree relatives (FDR) and control subjects. The association between glycated hemoglobin (HbA1c) and levels of metals was also evaluated. Patients and Methods: We studied 46 subjects with T2DM, 46 FDR, and 50 control subjects matched for age and sex. Serum concentrations of Cu, Zn, and Fe were measured by colorimetric kit. Fasting blood glucose (FBG) and HbA1c were assayed using the standard kit. Results: An imbalance in the levels of the studied metals was observed in both patients with T2DM and FDR. We found significantly decreased levels of Zn and higher levels of Cu and Fe in the patients with T2DM and FDR when compared with the control subjects (P < 0.05). HbA1c levels were positively correlated with Cu and Fe and inversely correlated with Zn in the patients with T2DM and FDR (P < 0.05). Conclusions: The patients with T2DM and FDR had altered contents of Cu, Zn, and Fe that might be a predisposing factor to the development of diabetes in future or vice versa the result of diabetes development. Impaired metabolism of these elements may contribute to the augmented risk of developing type 2 diabetes mellitus later in the life of their first-degree relatives.
Metabolism, 2009
Diabetes mellitus (DM) is associated with the alterations in the metabolism of copper (Cu), zinc (Zn), and magnesium (Mg). The aim of the present study was to investigate plasma levels of these elements in patients with DM and in healthy subjects. Association between glycated hemoglobin and levels of metals was also evaluated. We studied 36 subjects with DM (type 1, 11; type 2, 25) and 34 healthy subjects matched for age, sex, and duration of diabetes. Plasma concentrations of Cu, Zn, and Mg were measured by atomic absorption spectrometry. An imbalance in the levels of studied metals was observed in both type 1 and type 2 DM. We found higher levels of Cu (P b .001) and Cu/Zn ratio (P b .0001
Indian journal of Medical Biochemistry, 2018
Introduction: Diabetes mellitus (DM) is an epidemic facing the world today. The disease is characterized by a multitude of metabolic derangements which eventually lead to hyperglycemia and its associated complications. Trace elements, such as copper and zinc act as cofactors for essential enzymes of the metabolic pathways. Studies have reported conflicting results about their purported role in DM. Materials and methods: The study was conducted on 22 newly diagnosed cases of type II DM (T2DM) and 30 age-and sexmatched healthy controls over a period of 2 months under the Indian Council of Medical Research Short Term Research Studentship (ICMR-STS) scheme. Blood glucose, serum zinc, copper, and glycated hemoglobin (HbA1c) levels were estimated using commercially available kits on Transasia XL 640. Data were collected and analyzed using appropriate statistical tests. Results: The zinc levels were significantly decreased in the cases as compared with controls while there was no significant difference in the copper levels. A positive correlation between the copper and zinc levels was seen in the cases. Conclusion: Trace elements play an important role in the maintenance of blood sugar levels and an in-depth understanding of the underlying pathways may help in a better management of DM.
Copper, zinc, and magnesium levels in non-insulin dependent diabetes mellitus
Postgraduate Medical Journal, 1998
A relationship has been reported between trace elements and diabetes mellitus. This study evaluated the role of such a relationship in 83 patients with non-insulin dependent diabetes mellitus (40 men and 43 women), with a mean duration of diabetes of 3.9 ± 3.6 years. Patients with nephropathy were excluded. Thirty healthy nondiabetic subjects were studied for comparative analysis. Subjects were subdivided into obese and non-obese. Diabetic subjects were also subdivided into controlied and uncontrolled groups; control was based on fasting blood glucose and serum fructosamine levels. Plasma copper, zinc and magnesium levels were analysed using a GBC 902 double beam atomic absorption spectrophotometer. Plasma zinc and magnesium levels were comparable between diabetic and nondiabetic subjects, while copper levels were significantly elevated (p<0.01) in diabetic patients. Age, sex, duration and control of diabetes did not influence copper, zinc, or magnesium concentrations. We conclude that zinc and magnesium levels are not altered in diabetes mellitus, but the increased copper levels found in diabetics in our study may merit further investigation of the relationship between copper and non-insulin dependent diabetes mellitus.
Alqalam journal of Medical, Applied and Sciences, 2022
Type 2 diabetes mellitus (DM) is associated with increased morbidity and mortality due to the development of complications, especially due to poor glycemic control. Trace elements especially zinc and copper are cofactors of many enzymatic reactions which are involved in protein, lipid and glucose metabolism. Obesity is a chronic condition linked to disturbances in the metabolism of zinc and copper. The aim of the study was to estimate zinc and copper levels in type2 diabetes mellitus patients and to investigate their relations to glycemic control and body mass index (BMI). The study included 46 type2 diabetic patients and 43 healthy subjects aged 30-60 years for both sex (males and females). Blood glucose, HbA1c, lipid profile parameters were biochemically estimated in the study along with the measurement of BMI and systolic, diastolic blood pressure. All the results were statistically analyzed and were significant between the study and control groups. Zinc levels were inversely correlated with serum glucose, HbA1c, serum cholesterol, Triglyceride, LDL cholesterol, systolic, diastolic blood pressure and BMI levels and positively correlated with HDL cholesterol. Copper levels were positively correlated with blood glucose, HbA1c, serum cholesterol, Triglyceride, LDL cholesterol, systolic, diastolic blood pressure and BMI levels and negatively with HDL cholesterol. It is concluded that zinc and copper levels play major roles in glycemic control and alterations in lipid profile parameters among type 2 diabetes mellitus patients. Obesity contributes to changes in zinc and copper levels.
Serum Zinc and Copper Concentrations and Cu/Zn ratios in Patients with Hepatopathies or Diabetes
Journal of Trace Elements in Medicine and Biology, 1998
The serum zinc and copper levels, as well as Zn/Cu ratios, were determined in 30 patients (18 with diabetes and 12 with hepatopathies) and compared to healthy-age matched controls by atomic absorption spectrometry. Serum Zn (0.946 ± 0.302 mg/I) and Cu (0.952 ± 0.355 mg/l) concentrations were not significantlydifferent in patients with hepatopathies as compared to controls (p>0.05). Serum Zn concentrations (0.778 ± 0.164 mg/l) were significantly lower in diabetic patients than those determined in controls (p<O.Ol). In contrast, Cu levels (0.987 ± 0.305 mg/l) were not significantly different (p>0.05) than in controls. Serum Cu/Zn ratios were not significantly different in patients with diabetes or hepatopathies than those measured in healthy controls (p>0.05). In patients, no statistically significant differences were observed in the Zn, Cu and Cu/Zn with respect to sex (p>0.05) or age (p>0.05).
Biological Trace Element Research, 2008
There is accumulating evidence that the metabolism of several trace elements is altered in diabetes mellitus and that these nutrients might have specific roles in the pathogenesis and progress of this disease. The aim of present study was to compare the level of essential trace elements, chromium (Cr), copper (Cu), iron (Fe), manganese (Mn), nickel (Ni), and zinc (Zn) in biological samples (whole blood, urine, and scalp hair) of patients who have diabetes mellitus type 2 (n = 257), with those of nondiabetic control subjects (n = 166), age ranged (45–75) of both genders. The element concentrations were measured by means of an atomic absorption spectrophotometer after microwave-induced acid digestion. The validity and accuracy was checked by conventional wet-acid-digestion method and using certified reference materials. The overall recoveries of all elements were found in the range of (97.60–99.49%) of certified values. The results of this study showed that the mean values of Zn, Mn, and Cr were significantly reduced in blood and scalp-hair samples of diabetic patients as compared to control subjects of both genders (p < 0.001). The urinary levels of these elements were found to be higher in the diabetic patients than in the age-matched healthy controls. In contrast, high mean values of Cu and Fe were detected in scalp hair and blood from patients versus the nondiabetic subjects, but the differences found in blood samples was not significant (p < 0.05). These results are consistent with those obtained in other studies, confirming that deficiency and efficiency of some essential trace metals may play a role in the development of diabetes mellitus.