Further sesquiterpenoids and phenolics from Taraxacum officinale (original) (raw)
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Sesquiterpenoids and phenolics from roots of Taraxacum udum
Fitoterapia, 2010
From roots of Taraxacum udum, two new and four known sesquiterpene lactones were isolated, together with five known phenolic compounds. The new compounds were characterized as 11β, 13-dihydrotaraxinic acid and taraxinic acid 6-O-acetyl-β-glucopyranosyl ester by spectroscopic methods, especially 1D and 2D NMR, and by comparison with structurally related compounds. The plant material was shown to be a good source of taraxinic acid derivatives.
Natural Product Research, 2020
The chemical studies of roots and aerial parts of Taraxacum portentosum Kirschner & St ep anek, a member of the section Palustria (H. Lindb.) Dahlst. (Asteraceae), led to the isolation of one new eudesmanolide and 13 known compounds, including five sesquiterpenoids: taraxinic acid, 11b,13-dihydrotaraxinic acid, taraxinic acid b-glucopyranosyl ester and its 11b,13-dihydroderivative, ixerin D, one apocarotenoidloliolide and seven phenolics: scopoletin, 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-1-propanone, methyl p-hydroxyphenylacetate, 5-methoxy-eugenyl-4-O-b-glucopyranoside, syringin, dihydroconiferin, and dihydrosyringin. Their structures were established by 1 H NMR. The new compound was characterized as 3-oxo-4bH-11,13-eudesmen-12,6-olide-8-O-b-glucopyranoside based on spectroscopic data (1 D and 2 D NMR) and HRESI mass spectrometry.
Sesquiterpenoids and phenolics from Taraxacum hondoense
Fitoterapia, 2005
Eleven sesquiterpene lactones, including the new guaianolide 11h-hydroxydeacetylmatricarin-8-O-h-glucopyranoside, along with four known phenolic glucosides were isolated from Taraxacum hondoense. The compounds were characterized by spectral methods.
Anti-tumour effect of combinations of three acids isolated from Taraxacum officinale
Acta Veterinaria Brno, 2022
Taraxacum officinale (TO) is a well-known medicinal plant used in folk medicine for its variety of biological activities. In this study a methanolic extract from roots was used to examine its anti-tumour effect by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) viability assay on two mouse tumour cell lines, fibrosarcoma and hepatoma cell lines. Normal hepatocyte and fibroblast cell lines were used as a control. Furthermore, three active compounds were isolated from the extract, caffeic acid, chlorogenic acid, and ursolic acid, in order to investigate their cytotoxicity and possible interactions between them in their combinations on the same tumour and non-tumour cell lines. The anti-tumour effect of the TO extract was confirmed on the fibrosarcoma cell line in a dose dependent manner. The anti-proliferative acting of each acid was described on both cancer cell lines and for the first time the combinations of these acids were investigated and their commo...
Ethnobotany of the genus Taraxacum-Phytochemicals and antimicrobial activity
Plants belonging to the genus Taraxacum have been used in traditional healthcare to treat infectious diseases including food-borne infections. This review aims to summarize the available information on Taraxacum spp., focusing on plant cultivation, ethnomedicinal uses, bioactive phytochemicals, and antimicrobial properties. Phyto-chemicals present in Taraxacum spp. include sesquiterpene lactones, such as taraxacin, mongolicumin B, and taraxinic acid derivatives; triterpenoids, such as taraxasterol, taraxerol, and officinatrione; and phenolic derivatives, such as hydroxycinnamic acids (chlorogenic, chicoric, and caffeoyltartaric acids), coumarins (aesculin and cichoriin), lignans (mongolicumin A), and taraxacosides. Aqueous and organic extracts of different plant parts exhibit promising in vitro antimicrobial activity relevant for controlling fungi and Gram-positive and Gram-negative bacteria. Therefore, this genus represents a potential source of bioactive phytochemicals with broad-spectrum antimicrobial activity. However, so far, preclinical evidence for these activities has not been fully substantiated by clinical studies. Indeed, clinical evidence for the activity of Taraxacum bioactive compounds is still scant, at least for infectious diseases, and there is limited information on oral bioavailability, pharmacological activities, and safety of Taraxacum products in humans, though their traditional uses would suggest that these plants are safe.
Eudesmanolides and inositol derivatives from Taraxacum linearisquameum
Phytochemistry, 1999
The methanol extract of subaerial parts of Taraxacum linearisquameum Soest afforded two eudesmane type sesquiterpene lactones, 2-hydroxysantamarine-1-D-glucopyranoside (2) and 3hydroxy-4H-3-dihydrosantamarine--D-glucopyranoside (3) and two inositol derivatives, (1S,2S,4R,5S)-2,3,4,6-tetrahydroxy-5-[2-(4-hydroxyphenyl)acetyl]oxycyclohexyl-2-(4hydroxyphenyl)acetate (4) and (2S,3R,5R,6S)-2,3,5,6-tetrahydroxy-4-[2-(4hydroxyphenyl)acetyl]oxycyclohexyl-2-(4-hydroxy-phenyl)acetate (5). Additionally, the known compound taraxinic acid -D-glucopyranosyl ester (1) has been isolated.
International Journal of Molecular Sciences, 2025
Taraxacum officinale (dandelion) is a perennial flowering plant of the Asteraceae family that has spread globally and is well-known for its traditional uses. The aim of this work is to provide a detailed review of scientific literature on the genus Taraxacum from the last two decades, with particular emphasis on the biological and pharmacological characteristics of dandelions. The traditional use of Taraxacum species and their potential use in medicine are assessed. In addition, individual papers describing principal pathways and molecules modulated by Taraxacum in antitumoral, anti-inflammatory, antidiabetic, hepatoprotective, immunomodulatory, antimicrobial, and antioxidant activities are presented. This review of phytochemical studies reveals that dandelions contain a wide range of bioactive compounds, such as polyphenols, phytosterols, flavonoids, carotenoids, terpene, and coumarins, whose biological activities are actively explored in various areas of human health, some constituents having synergistic activities, including antioxidant, antimicrobial, anti-inflammatory and anticancer activities. The study provides a screening of Taraxacum sp. chemical composition, an assessment of the main pharmacological properties, and a description of relevant studies supporting the use of dandelion for its particularly valuable and diversified therapeutic potential in different diseases.
Taraxacum officinale: a high value less known medicinal plant
Annals of Plant Sciences, 2014
The family Asteraceae, best represented by the species of Taraxacum officinale , is known world wide for its manifold uses. It is widely used to cure kidney disease, swelling, skin problems, heart burn, eye inflammation, bone fractures, diabetes mellitus, hypertension, gastrointestinal complaints, warts, liver/gallbladder problems, hepatitis B, cancer, etc., and widely used in modern medicine. Therefore, an attempt has been made to assess the medicinal potential of the species both in traditional and modern medicine system. This paper provides the relevant information about medicinal properties of the high value medicinal plants. Further, we have tried to compile all the possible information regarding the medicinal potential of this plant. So far only limited scientific studies have been conducted on this plant. So further research is required to highlight the potential of the plant.
FARMACIA, 2023
A phytochemical investigation of the aerial parts of Taraxacum gracilens Dahlst. (Asteraceae) yielded two coumarins (esculetin (1) and cichorin (2)), two flavonoids (luteolin (3) and chrysoeriol (4)) and four phenolic acids (caffeic acid (5), ferulic acid (6), chlorogenic acid (7) and 3,5-dicaffeoylquinic acid (8)). The presence of these compounds has been acknowledged for the first time in this species. The polyphenolic content and antioxidant activities of EtOH extract and PE, CHCl3, AcOEt and BuOH fractions of the EtOH extract from the aerial parts of Taraxacum gracilens Dahlst. were investigated. We evaluated the antioxidant activities of the extract and its fractions by measuring their ability to inhibit lipid peroxidation induced by Fe3+-ascorbate, their reducing power and their hydrogen donor activities. Also, the inhibitory activity against COX-2 was evaluated to determine the anti-inflammatory activity of the samples. The AcOEt and CHCl3 fractions showed the highest antioxidant activity due to their richest phenolic contents, followed by the BuOH fraction, whereas the EtOH extract, containing the least phenolics, showed the weakest activity. The PE fraction did not show any antioxidant activity due to its lack of phenolic content. EtOH extracts and their fractions showed inhibitory activity against COX-2.
International Journal of Pharmacognosy and Phytochemical Research
Introduction: Plants belonging to the genus Taraxacum have been used in traditional medicine. Nowadays, extracts of these plants have been reported for the treatment of diseases, including liver disorders. Increasing interest and research on these plants also revealed its potential for treating cancer. This study aims to evaluate the antioxidant activity and cytotoxic properties of crude extracts from aerial parts of Taraxacum hispanicum H.Lindb, against human hepatocarcinoma (HepG2). Material and methods: Evaluation of the antioxidant properties was performed using DPPH in vitro test, superoxide scavenging assay and Fe2+ chelating activity. MTT assay was used to determine metabolic activity, for 24 and 48 hours. Results: For antioxidant capacity of the ethanolic extract (overall the one with the best results), IC50 values were 62.4 ± 6.7 μg/ml (DPPH radical scavenging activity) 53.9 ± 10.3 μg/ml (Fe2+ chelating activity) and 2.0 ± 0.3 μg/ml (superoxide scavenging assay). The aqueou...