Truncated Tau with the Fyn-binding domain and without the microtubule-binding domain hinders the myelinating capacity of an oligodendrocyte cell line (original) (raw)
2008, Journal of Neurochemistry
are observed in the Fyn-and laminin-2-minus mice. Fynminus mice have a severe myelin deficit in forebrain at all ages (Sperber et al. 2001), whereas cervical spinal cord has no decrease in myelin content, number of OLGs, or number of myelinated fibers (Sperber et al. 2001). Also, the laminin-2-minus mice have myelin deficit in the brain not the spinal cord (Chun et al. 2003). Recently, Lee et al. (2006) showed that transgenic mice that express a dominant-negative beta1 Integrin protein (lacking the C-terminal tail) have hypomyelinated axons in spinal cords and optic nerves with a significant increase in the number of unmyelinated axons within the spinal cord and optic nerves. In contrast, the corpus callosum has no myelin defects, whereas during remyelination of the corpus callosum the actual percentage of myelinated axons is reduced (Lee et al. 2006). These previous studies provided evidence that integrin-dependent pathways are important during myelination; however, the conditional ablation of the beta 1-integrin gene in oligodendroglial cells did not affect CNS myelination and remyelination (Benninger et al. 2006). Therefore, these results indicate that both integrin-dependent and-independent