Conidiobolomycose rhinofaciale avec localisations cervicales, thoraciques et brachiales : à propos d’un cas nigérian (original) (raw)
Related papers
Histopathologic features of Buruli ulcer patients in a referral hospital in South Eastern Nigeria
Zenodo (CERN European Organization for Nuclear Research), 2023
Background: Buruli ulcers are characterized by massive subcutaneous tissue destruction which can be treated effectively and completely when detected early. Characteristic histopathologic changes are considered one of the confirmatory laboratory methods for the diagnosis of Buruli ulcers. Objective: To assess the histopathologic features of Buruli ulcer cases presenting in a referral hospital in South Eastern Nigeria. Methods: A cross-sectional prospective study was carried out among a cohort of 39 Buruli ulcer disease patients referred to a referral hospital in South Eastern Nigeria between July and December 2021. A semi-structured, interviewer-administered questionnaire was used to collect data on the socio-demographic characteristics of the respondents while the incisional skin biopsy specimens obtained from the patients in the course of their treatments were sent for histopathologic evaluation. Data were analyzed using SPSS version 22; with alpha set at p-value ≤ 0.05. Results: Twenty one (53.8%) of the study participants were males while 18 (46.2%) were females. Their mean age was 28.41±18.668. Epidermal hyperplasia and elastolysis of the dermis were present in 35 (89.7%) of the patients. There was inflammation of the dermis and subcutis in 34 (87.2%) of the patients while necrosis of the subcutis was present in 38 (97.4%) of the patients. AFB was not visualized in any of the lesions of the patients. Overall, the characteristic histopathologic features of Buruli ulcer were demonstrated in 33 (84.6%) of the patients and four (10.3%) of the patients had features of squamous cell carcinoma while 2 (5.1%) had features of varicose veins.
Rare Occurrence: Buruli Ulcers in Gulu, Northern Uganda. A Case report
A Buruli ulcer (BU) is a disease caused by infection with Mycobacterium ulcerans. It is one of the most neglected but treatable tropical diseases. The causative organism is from the family of mycobacteriacae which causes tuberculosis and leprosy. Buruli ulcer has received the least attention than these other two diseases. Its infection leads to extensive destruction of skin and soft tissue and formation of large ulcers usually on the legs or arms. Early diagnosis and treatment are vital in preventing such disabilities. We describe a case report of Buruli ulcer diagnosed using culture and histology and successfully managed in Gulu Regional Hospital using medical and surgical methods.
Cutaneous basidiobolomycosis: Seven cases in southern Benin
Annales de Dermatologie et de Vénéréologie, 2017
Background.-Cutaneous basidiobolomycosis is the most common form of entomophthoramycosis. Herein we report seven cases of cutaneous basidiobolomycosis. Patients and methods.-A retrospective observational study was conducted at the Buruli ulcer treatment centre in Pobè and at the national teaching hospital in Cotonou from 2010 to 2015. Results.-Seven cases of cutaneous basidiobolomycosis were diagnosed. The mean patient age was 9.53 years. There were 4 female and 3 male patients, all from southeast Benin. Clinically, the disease presented in all cases as a hard, well-defined, subcutaneous plaque with little inflammation, and which could easily be lifted from the deep structures but remained attached to the surface structures. The overlying skin was hyperpigmented. Plaques were localized to the buttocks or thighs. All patients had inflammatory anaemia with an accelerated
A case of squamous cell carcinoma occurring on a scar of Buruli ulcer in Bouake, Ivory Cost
Pan African Medical Journal, 2019
Buruli ulcer is infectious necrotizing panniculitis due to Mycobacterium ulcerans. Buruli ulcer is healed by leaving dystrophic, fibrous and retractile scars. On these scars can occur long-term squamous cell carcinoma. We report the first case of squamous cell carcinoma occurring on healing of Buruli ulcer. A 32-year-old woman with Buruli ulcer who has been cured for about 10 years is seen for ulcero-bulging knee swelling. The examination had revealed a large swelling of about ten centimeters in diameter, ulcero-budding, with an easily bleeding cauliflower appearance. The diagnosis of squamous cell carcinoma being retained without metastasis, resection of the tumor with scarring after one month without chemot herapy. There was no recurrence after six months of decline. The epidemiology of Buruli ulcer, responsible for scarring, explains t he young age of our patient and the localization of carcinoma on the limb. The carcinomatous degeneration of scars, especially the scars of old burns, is constantly reported. The characteristics of Buruli ulcer scars, which bring them closer to burn scars, may explain why they are particularly affected by carcinomatous degeneration. One could also mention the chronicity of the wound in this infection, or wonder if the mycobacteria itself coul d play a role in carcinogenesis. This observation is, in our opinion, an alarm signal. We must fear an outbreak of cases in the years to come. To this end, preventive measures should already be taken by sensitizing the patients for an early consultation before any modification of their scars. After recovery, Buruli ulcer seems to present a risk of long-term evolution to a cancer. The scars of this condition, which could be considered precancerous lesions.
Dermatopathology
Background: Buruli ulcer (BU) is a cutaneous infectious disease caused by Mycobacterium ulcerans. In this prospective study, we aim to clarify the main histopathological features of cutaneous BU based on 4-mm skin punch biopsies and to evaluate the diagnostic value of this method. Methods: Between 2011 and 2013, a prospective study was conducted in Cameroon. Dry swabs from ulcerative lesions and fine-needle aspirates of nonulcerative lesions were examined for Ziehl-Neelsen (ZN) staining, followed by PCR targeting IS2404 and culture. Two 4-mm punch biopsies were performed in the center and in the periphery of each lesion. Results: The 364 patients included in the study had 422 lesions (381 were ulcerative and 357 lesions were biopsied). Among the 99 ulcerated lesions with a final diagnosis of BU, histological features for BU were fulfilled in 32 lesions. 32/32 showed subcutaneous necrosis with a neutrophilic inflammatory infiltrate. 26/32 presented alcohol-resistant bacilli confirmed by ZN stain on histology. Conclusion: Punch biopsies help in establishing the correct diagnosis of BU and also in the differential diagnosis of chronic ulcers. The main histological feature for BU is diffuse coagulative necrosis of subcutaneous tissue, with acid-fast bacilli detected by ZN stain.