Clinicopathology & Molecular Analysis of Diffuse Intrinsic Pontine Glioma (DIPG) in Children - Insights from Past, Present, and Future Directions (original) (raw)

Journal for Research in Applied Sciences and Biotechnology

Diffuse Intrinsic Pontine Glioma, or DIPG, is a rare, highly aggressive, heterogeneous group of brainstem tumors. Around 10-20% of primary brain tumors are considered pediatric brain tumors, of which 10-15% are diffuse brainstem tumors. It is considered untreatable and surgically unremovable due to its intrinsic position within the brain. Over the years, applying radiotherapy and chemotherapy has not shown a better outcome. However, gene-targeted therapy has proven successful, but it is still in the developing phase. This article covers the various aspects of DIPG, from clinical and molecular definitions to a vision for a universally accepted novel approach to beat this severe condition by joining fundamental science and translational research.

Sign up for access to the world's latest research.

checkGet notified about relevant papers

checkSave papers to use in your research

checkJoin the discussion with peers

checkTrack your impact