Erken Gebelikte İdiopatik Trombositopenik Purpura Nedeniyle Oluşan İntrakranial Kanama (original) (raw)
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Turkiye Klinikleri Journal of Medical Sciences, 2007
Dünyada yaygın olarak kullanılan rekombinant hepatit B aşısının, lokal yan etkilerinin yanı sıra nadiren de olsa poliradikülonörit, santral sinir sistemi demiyelinizasyonu, hepatik disfonksiyon, otoimmün hemolitik anemi, immün trombositopeni gibi sistemik yan etkiler de bildirilmiştir. Biz de rekombinant hepatit B aşısının 3. dozundan 3 hafta sonra trombositopenik purpura gelişen 10 aylık olan 1 olgu saptadık. Olgunun şikayetleri öncesinde enfeksiyon geçirme ya da ilaç alım öyküsü yoktu. Otoimmün hastalığı ve malignensiyi düşündürecek klinik ve laboratuvar bulgu saptanmadı. Kemik iliği aspiarasyonu normaldi. Rekombinant hepatit B aşısı sonrası trombositopeni gelişebileceğini vurgulamak amacı ile bu olgu sunuldu.
İdiopatik Trombositopenik Purpuralı Çocukların Değerlendirilmesi
2009
Son 4 yıl içerisinde ITP tanısı almış pediatrik hastalarda başvuru ve klinik özelliklerinin tanımlanması, klinik gidişat, tedavi şekli ve komplikasyonların değerlendirilmesi; infeksiyon öyküsü, yaş, cinsiyet, tedavi şekli ve başvuru trombosit sayısının kronikleşme ve relaps üzerine etkilerinin belirlenmesi amaçlandı.
Perinatoloji Dergisi, 1996
Objective: İn this present study, we attempted to assess frequency and location of intracranial hemorrhages in cases of perinatal child death as well as possible etiological factors. Methods: For this purpose, e examined autopsy reports of a total of 246 perinatal death cases autopsied in Mortuary Section of Forencis Medicine Council. We further evaluated medical and other relevant records in 40 (16.3%) cases with intracranial bleeding. Results: 8 (20%) were stili birds and 32 (80%) were lifebirds as determined by autopsy in this 40 cases. Trauma had been inflicted ınutero in 1 case, during labour in 7 cases and in 9 postnatal period. İn 8 cases prolonged lobour was the cause of the intracranial hemorrhage. Where as, bleeding was precipitated by maternal and/or fetal pathological factors in 7 cases. İn evaluatıon other findings in 8 cases wıthout apparent etiological factor, we assumed that intracranial bleeding was caused by intrauterine trauma in 2 and postnatal traumatic impact in 6 cases. Conclussıon: Respectively or findings show that birth management mustbe performed in held care units and more meticulously furthermore a revision of the respective paragraph et the Turkısh penal code dealing with infanticide would be recommendable.
Suçiçeği Sonrasi Gelişen İmmün Trombositopenik Purpura: Olgu Sunumu
2000
SUMMARY Immun trombocytopenic purpura is the most common hemorrhagic disorder of the childhood and produced antibodies against platelets have major role in pathogenesis. Immun trombocytopenic purpura may be seen without any reason or secondary to underlying pathologies as infections. Here we present a case of immun thrombocytopenic purpura secondary to varicella infection.
Akut poststreptokoksik glomerülonefritli bir çocuk hastada idiyopatik trombositopenik purpura
Türk Pediatri Arşivi, 2011
A Ak ku ut t p po os st ts st tr re ep pt to ok ko ok ks si ik k g gl lo om me er rü ül lo on ne ef fr ri it tl li i b bi ir r ç ço oc cu uk k h ha as st ta ad da a i id di iy yo op pa at ti ik k t tr ro om mb bo os si it to op pe en ni ik k p pu ur rp pu ur ra a I Id di io op pa at th hi ic c t th hr ro om mb bo oc cy yt to op pe en ni ic c p pu ur rp pu ur ra a i in n a a c ch hi il ld d w wi it th h a ac cu ut te e p po os st ts st tr re ep pt to oc co oc cc ca al l g gl lo om me er ru ul lo on ne ep ph hr ri it ti is s
Yenidoğan yoğun bakım ünitemizdeki erken ve geç trombositopeni nedenlerinin değerlendirilmesi
Turkish Journal of Clinics and Laboratory, 2015
Trombositopeni yenidoğan döneminde sık görülen hematolojik sorunlardan biridir. Bu çalışmanın amacı yenidoğan yoğun bakım ünitemizde (YYBÜ) yatan hastalarda trombositopeni sıklığı ve nedenlerini belirlemektir. Gereç ve Yöntemler: Ocak 2011-Mayıs 2014 tarihleri arasında YYBÜ'de yatan hastalar dosya kayıtlarından geriye yönelik olarak incelendi. Postnatal ilk 72 saatte gözlenen trombositopeni erken, 72 saatten sonra görülenler ise geç trombositopeni olarak tanımlandı. Hastaların demografik ve klinik özellikleri ve laboratuar bulguları kaydedildi. Bulgular: Çalışma süresince YYBÜ' de trombositopeni sıklığı %11 idi. Erken trombositopeni gözlenen hastaların trombositopeni nedenleri plasental yetmezlik (n=14), 1 hastada aynı zamanda kromozom anomalisi, sepsis (n=14), maternal trombositopeni (n=7), perinatal asfiksi (n=6), hemofagositoz (n=1) idi. İki hastada yalancı trombositopeni, 4 hastada tanısal değerlendirme yapılamamakla birlikte, neonatal alloimmün trombositopeni düşünüldü. Geç trombositopeni gözlenen hastaların trombositopeni nedenleri kültür pozitif sepsis (n=15), klinik sepsis (n=10), NEK (n=7), TAR Sendromu (n=1), CMV enfeksiyonu (n=1) ve yalancı trombositopeni (n=5) idi. Sonuçlar: Çalışmamızda ilk 72 saat içinde tanı alan hastalarda trombositopeni genellikle gebelik veya doğum komplikasyonlarına bağlı iken, 72 saatten sonra tanı alan hastalar sıklıkla edinilmiş enfeksiyon veya nekrotizan enterokolitle ilişkilidir. Sonuç olarak, trombositopeninin erken veya geç olması etiyolojik açıdan önemlidir.
İdiopatik Trombositopenik Purpuralı Hastalarda Splenektomi: 109 Olgununun Analizi
Dicle Tıp Dergisi, 2012
Objectives: Splenectomy is performed in order to provide the treatment in the patients with severe idiopathic thrombocytopenic purpura, refractory to medical treatment. In this study, we aimed to investigate the postoperatif and longterm outcomes in the patients who underwent splenectomy with the diagnosis of idiopathic thrombocytopenic purpura. Materials and Methods: Between 2001-2010 at Dicle University Medical Faculty, General Surgery Department, a retrospective review of the 109 patients who had undergone splenectomy for ITP was reviewed. Age, gender, presence of accessory spleens and location, duration of the operation, number of preoperative platelet tranfusion, number of preoperative and postoperative blood transfusion, length of hospital stay, long-term outcomes, morbidity and mortality were recorded. Results: The mean age was 37.10 ± 16.62 (16-72), and there were 88 (80.7%) female and 21 (19.3%) male patients. The mean operation time was 44.87 ± 10:32 (30-120) minutes. The average postoperative blood and preoperative platelet transfusion were 1.63 ± 0.85 (0-3) and 2.01 ± 0.71 (1-3) units, respectively. The accessory spleens were encountered in 20 (18.3%) patients at the ultrasonographic examination. And also the accessory spleens were encountered in 23 (21.1%) patients during operation and confirmed with histopathologic examination. The most common localization of accessory spleens were splenic hilus. The postoperative complications were occurred in 16 patients (14.7%) and the most complication was atelectasia. The mean length of hospital stay was 4:56 ± 2:45 (2-12) days. Patients were followed for an average of 28 (9-48) months. At the follow-up period, 1 (0.9 %) patient had died. Conclusion: Splenectomy can be performed safely in the treatment of the patients with idiopathic thrombocytopenic purpura unresponsive to medical treatment. Long-term good results can be obtained with splenectomy in these patients. The accessory spleens should not be overlooked to prevent recurrences.
2016
The thrombocytopenia-absent radii (TAR) syndrome is characterized by bilateral absence of the radii in the presence of both thumbs and thrombocytopenia. Lower limb involvement and cardiac, gastrointestinal, renal, and genital abnormalities may also be seen in the patients with TAR syndrome. Thrombocytopenia may be congenital or may develop within the first few weeks to months of life; in general, thrombocytopenic episodes decrease with age. Cow’s milk intolerance is common and can be associated with exacerbation of thrombocytopenia. Anemia has been described in a large number of patients. It is not clear whether this is entirely related to blood loss from bleeding secondary to thrombocytopenia or whether there may be a shortened RBC lifespan. There appears to be a hemolytic component to the anemia, particularly during the first year of life. TAR syndrome should be kept in mind in a neonate with thrombocytopenia that is associated with hemolytic anemia and cow’s milk intolerance shou...