Curcuma Longa: The Golden Spice, Powerfulanticancer Agent in Breast Cancer Treatment (original) (raw)

2019, Era's Journal of Medical Research

Various experiments have proved that Curcuma longa (CL), the Golden Spice of our kitchen, exibits anticancer effects to inhibit the uncontrolled cell division and metastasis of carcinoma cells, by the cell cycle arrest and finally promote to programmed cell death. In particular, CL exhibits the most powerful phytocompound to affect human breast cancer, the most prevalent type of cancer among the women, throughout the world. The main compounds present in CL can be classified as Curcuminoids and Non-curcuminoids, which shows the anticancer, anti-inflamatory functions for cancer cells. It helps in powerful inhibition in low concentration on breast cancer cell lines that exhibit the estrogen receptor negative(ER) and sensitizes the cells towards the anticancer drugs in low dose. Above all, it promotes the cells towards apoptosis, which does not have hormone receptor expression. Curcuminoids and non curcuminoids inhibit the excessive cell division of breast cancer stem cells (BCSC). Prevention of BCSC proliferation is performed by suppressing metastasis and adherence of the cells with one another, ultimately limiting tumor formation. The main powerful phyto-compound present in CL, curcumin, causes the yellow coloration of it, has drawn the main interest as the chemosensitizing agent also. Different mode of cancer cell targeting and apoptosis is discussed.

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