B1CTcu5 analogs as promising antimicrobial peptides, replacing the sequence cysteine (original) (raw)

The study investigates the synthesis and antimicrobial efficacy of homologues of the B1CTcu5 peptide, originally derived from the Indian frog, Clinotarsus curtipe. Given the challenges posed by bacterial resistance and the need for new therapeutic agents, this research explores the replacement of cysteine in the peptide structure. Various analogs were evaluated for their antimicrobial activity against Salmonella Typhi, Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus, showing promising minimum inhibitory concentrations (MIC) in the range of 15.6 - 62.5 µg/mol. These findings suggest that substituting cysteine with amino acids like alanine and lysine can enhance the potential of B1CTcu5 analogs as effective antimicrobial agents.