Selective muscarinic antagonists differentially affect in vivo acetylcholine release and memory performances of young and aged rats (original) (raw)

Neuroscience, 1997

Abstract

Brain acetylcholine release and memory performance were investigated in young (three- to six-months) and old (20- to 24-months) rats. Acetylcholine release was measured in vivo in the cortex and hippocampus of freely-moving animals, under basal conditions and in the presence of the following muscarinic antagonists: scopolamine, (±)-5,11-dihydro-11-{[(2-[2-[(dipropylamino) methyl]-1-piperidinyl} ethyl) amino] carbonyl}-6H-pyrido(2,3-b)(1,4)-benzodiazepine-6-one (AFDX 384) and pirenzepine. The amount of acetylcholine released

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