Zika Virus Seroprevalence, French Polynesia, 2014-2015 (original) (raw)
Related papers
2019
SUMMARYBackgroundSerosurveys published following major outbreaks of Zika virus (ZIKV) have so far shown a high level of seroprevalence from samples collected within 12 months of the first confirmed case. A common assumption is that ZIKV infection confers long-term protection against reinfection, preventing ZIKV from re-emerging in previously affected areas for many years. However, the long-term immune response to ZIKV following an outbreak remains poorly documented.MethodsWe compared results from eight serological surveys, with sample sizes ranging from 49 to 700, before and after known ZIKV outbreaks in the Pacific region: five from cross-sectional studies of schoolchildren and the general population in French Polynesia over a seven-year period; and three from a longitudinal cohort in Fiji over a four-year period.FindingsWe found strong evidence of a decline in seroprevalence in both countries over a two-year period following first reported ZIKV transmission. In the cohort in Fiji,...
eLife, 2020
It has been commonly assumed that Zika virus (ZIKV) infection confers long-term protection against reinfection, preventing ZIKV from re-emerging in previously affected areas for several years. However, the long-term immune response to ZIKV following an outbreak remains poorly documented. We compared results from eight serological surveys before and after known ZIKV outbreaks in French Polynesia and Fiji, including cross-sectional and longitudinal studies. We found evidence of a decline in seroprevalence in both countries over a two-year period following first reported ZIKV transmission. This decline was concentrated in adults, while high seroprevalence persisted in children. In the Fiji cohort, there was also a significant decline in neutralizing antibody titres against ZIKV, but not against dengue viruses that circulated during the same period.
Impact of Zika Virus Emergence in French Guiana: A Large General Population Seroprevalence Survey
The Journal of Infectious Diseases, 2019
Background Since the identification of Zika virus (ZIKV) in Brazil in May 2015, the virus has spread throughout the Americas. However, ZIKV burden in the general population in affected countries remains unknown. Methods We conducted a general population survey in the different communities of French Guiana through individual interviews and serologic survey during June–October 2017. All serum samples were tested for anti-ZIKV immunoglobulin G antibodies using a recombinant antigen-based SGERPAxMap microsphere immunoassay, and some of them were further evaluated through anti-ZIKV microneutralization tests. Results The overall seroprevalence was estimated at 23.3% (95% confidence interval [CI], 20.9%–25.9%) among 2697 participants, varying from 0% to 45.6% according to municipalities. ZIKV circulated in a large majority of French Guiana but not in the most isolated forest areas. The proportion of reported symptomatic Zika infection was estimated at 25.5% (95% CI, 20.3%–31.4%) in individ...
Eurosurveillance, 2016
HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Zika emergence in the French Territories of America and description of first confirmed cases of Zika virus infection on Martinique,
Zika Virus : A Literature Review
2016
Zika virus is a mosquito-borne arbovirus first isolated in the Zika forest in 1947. After a period of obscurity, it emerged in 2007 with an outbreak in the Yap Island, Federated States of Micronesia followed by another outbreak in 2013 in French Polynesia. During the French Polynesian outbreak, Zika virus was found to be associated with neurological complications like Guillain-Barre Syndrome. The current epidemic in Brazil also demonstrated an increased incidence of congenital malformations and neurological complications forcing the World Health Organization to declare Zika fever as a Public Health Emergency of International Concern (PHEIC). This review attempts to compile the current knowledge available on the virology, clinical features, complications, diagnosis, treatment and control of Zika virus infection.
Performance of 2 Commercial Serologic Tests for Diagnosing Zika Virus Infection
Emerging Infectious Diseases
Zika virus, a mosquito-transmitted flavivirus, has been isolated from sentinel monkeys, mosquitoes, and sick persons in Africa and Southeast Asia. Serologic surveys indicate that Zika virus infections can be relatively common among persons in southeastern Senegal and other areas of Africa, but that Zika virus-associated disease may be underreported or misdiagnosed. In 2007, a large outbreak of Zika virus infection occurred on Yap Island in the southwestern Pacific that infected ≈70% of the island's inhabitants, which highlighted this virus as an emerging pathogen. The purpose of this study was to investigate and report 3 unusual cases of arboviral disease that occurred in Colorado in 2008. Clinical and serologic evidence indicate that two American scientists contracted Zika virus infections while working in Senegal in 2008. One of the scientists transmitted this arbovirus to his wife after his return home. Direct contact is implicated as the transmission route, most likely as a sexually transmitted infection.
Journal of Medical Virology, 2017
Zika virus (ZIKV) viremia is reported as low and transient; however, these estimates rely on limited data. We report RNA loads in sera collected from symptomatic patients during the 2013-2014 French Polynesian ZIKV outbreak. We performed molecular detection of ZIKV RNA in sera from 747 patients presenting with suspected acute phase ZIKV infection. Among patients with confirmed infection, we analyzed the duration of viremia, assessed viral RNA loads and recorded the main clinical symptoms. A total of 210/747 (28.1%) sera tested positive using a ZIKV-specific RT-PCR. Viral RNA loads in symptomatic patients that ranged from 5 to 3.7 × 10 6 copies/mL (mean 9.9 × 10 4 copies/mL) were not related to a particular clinical presentation, and were significantly lower than those previously obtained from asymptomatic ZIKV infected blood donors. The rate of detection of ZIKV RNA in sera from suspected cases of acute phase ZIKV infection was low. ZIKV RNA loads were lower in symptomatic patients compared to asymptomatic blood donors and were lower than RNA loads usually reported in dengue infections. As there is no abrupt onset of symptoms in ZIKV infections, we suggest that infected patients sought for medical attention when viremia was already decreasing or had resolved.
Neurologic Clinics
Zika virus was first identified in a rhesus monkey in the Zika Forest of Uganda in 1947. 1 It was later found in people with febrile illnesses in West Africa in 1954. 2 It then spread to Indonesia, 3 Micronesia, 4 the Philippines, 5 French Polynesia, 6 and Easter Island-South Pacific 7 in 2014. Zika virus infections were not documented on mainland South America until the first report of autochthonous transmission in Brazil in May 2015. The conclusion at that time was that Zika virus was introduced into Brazil during the 2014 World Cup Football. 8 This was not supported due to the fact that no Pacific countries with documented Zika virus infection had competed in the World Cup competition. However, Pacific countries had participated in the August 2014 Va'a World Sprints canoe championship, which was held in Rio de Janeiro, suggesting that introduction of Zika virus into Brazil could have occurred then. 9 Another possibility was the introduction of Zika virus to Brazil by travelers from Chile. 10 Since its introduction into Brazil The authors have nothing to disclose.