Cyclic Enkephalin Analogues with Exceptional Potency and Selectivity for δ-Opioid Receptors (original) (raw)

Cyclic Enkephalin Analogues with Exceptional Potency and Selectivity for δ-Opioid Receptors 1

Victor Hruby is to

Journal of Medicinal Chemistry, 1997

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Cyclic enkephalin analogs with exceptional potency at peripheral .delta. opioid receptors

Victor Hruby is to

Journal of Medicinal Chemistry, 1994

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A novel cyclic enkephalin analogue with potent opioid antagonist activity

Peter Schiller

Bioorganic & Medicinal Chemistry Letters, 2004

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Cyclic enkephalin analogs that are hybrids of DPDPE-related peptides and Met-enkephalin-Arg-Gly-Leu: prohormone analogs that retain good potency and selectivity for δ opioid receptors

Victor Hruby

The Journal of Peptide Research, 1999

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Ring substituted and other conformationally constrained tyrosine analogs of [cyclic] [D-Pen2,D-Pen5]enkephalin with .delta.-opioid receptor selectivity

Victor Hruby

Journal of Medicinal Chemistry, 1992

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N-Methylated Cyclic Enkephalin Analogues Retain High Opioid Receptor Binding Affinity

Peter Schiller

Chemical Biology & Drug Design, 2010

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Synthesis and Biological Activities of Cyclic Lanthionine Enkephalin Analogues: δ-Opioid Receptor Selective Ligands

Peter Schiller

Journal of Medicinal Chemistry, 2002

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Development of Novel Enkephalin Analogues that Have Enhanced Opioid Activities at Both μ and δ Opioid Receptors

Chad Park

2007

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Synthesis and Evaluation of N,N-Dialkyl Enkephalin-Based Affinity Labels for δ Opioid Receptors

Jane Ishmael

Journal of Medicinal Chemistry, 2000

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Single residue modifications of the delta opioid receptor selective peptide, [d-Pen2,d-Pen5]-enkephalin (DPDPE)

Henry I. Mosberg

International Journal of Peptide and Protein Research, 2009

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Ring substituted and other conformationally constrained tyrosine analogues of [D-Pen2,D-Pen5]enkephalin with delta opioid receptor selectivity

Victor Hruby is to

Journal of medicinal chemistry, 1992

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A cyclic enkephalin analog with high in vitro opiate activity

Peter Schiller

Proceedings of the National Academy of Sciences, 1980

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Development of μ/δ Opioid Ligands: Enkephalin Analogues Containing 4-Anilidopiperidine Moiety

Victor Hruby is to

Advances in Experimental Medicine and Biology, 2009

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Dicarba Analogues of the Cyclic Enkephalin Peptides H-Tyr- c [ d -Cys-Gly-Phe- d (or l )-Cys]NH 2 Retain High Opioid Activity †

Peter Schiller

Journal of Medicinal Chemistry, 2007

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Preparation and evaluation at the delta opioid receptor of a series of linear Leu-enkephalin analogues obtained by systematic replacement of the amides

Yves Dory

2013

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Comparative binding properties of linear and cyclic δ-selective enkephalin analogues: [3H]-[D-Thr2, Leu5] enkephalyl-Thr6 and [3H]-[D-Pen2, D-Pen5] enkephalin

Bernard Roques

FEBS Letters, 1985

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Synthesis and activity profiles of novel cyclic opioid peptide monomers and dimers

Peter Schiller

Journal of Medicinal Chemistry, 1985

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Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors

Victor Hruby is to

Proceedings of the National Academy of Sciences, 1983

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Exploring the backbone of enkephalins to adjust their pharmacological profile for the δ-opioid receptor

Yves Dory

2010

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Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogs: effect of conformational constraints on opiate receptor selectivity

Peter Schiller

Journal of Medicinal Chemistry, 1982

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Synthesis and binding characteristics of a novel enkephalin analogue, [3H]Tyr-d-Ala-Gly-Phe-d-Nle-Arg-Phe

Judit Farkas

Peptides, 2003

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Topographically designed analogs of [cyclic] [D-Pen2,D-Pen5]enkephalin

Richard Knapp

Journal of Medicinal Chemistry, 1991

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A novel cyclic opioid peptide analog showing high preference for μ-receptors

Toai Nguyen

Biochemical and Biophysical Research Communications, 1985

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Dalargin and [Cys-(O2NH2)]2 analogues of enkephalins and their selectivity for μ opioid receptors

A. Bocheva

General Pharmacology: The Vascular System, 1995

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Irreversible labelling of the opioid receptors by a melphalan-substituted [Met5]enkephalin-Arg-Phe derivative

Anna Borsodi, Gyorgy Orosz

European Journal of Pharmacology, 1999

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