Pim1 Kinase Overexpression Enhances ckit+ Cardiac Stem Cell Cardiac Repair Following Myocardial Infarction in Swine (original) (raw)

2016, Journal of the American College of Cardiology

BACKGROUND-Pim1 kinase plays an important role in cell division, survival, and commitment of precursor cells towards a myocardial lineage, and overexpression of Pim1 in ckit + cardiac stem cell (CSC) enhances their cardioreparative properties. OBJECTIVES-We sought to validate the effect of Pim1-modified CSCs in a translationally relevant large animal preclinical model of myocardial infarction (MI). METHODS-Human CSCs (hCSCs, n = 10), hckit + CSCs overexpressing Pim1 (Pim1 + ; n = 9), or placebo (n = 10) were delivered by intramyocardial injection to immunosuppressed Yorkshire swine (n = 29) 2 weeks after MI. Cardiac magnetic resonance and pressure volume loops were obtained before and after cell administration.

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