N-(Diethylcarbamothioyl)-4-nitrobenzamide (original) (raw)

2010, Acta Crystallographica Section E Structure Reports Online

AI-generated Abstract

N-(Diethylcarbamothioyl)-4-nitrobenzamide was synthesized and characterized, revealing a compound where the 4-nitro and carbonyl groups are nearly coplanar with the benzene ring. The structure features significant twisting of the diethylcarbamothioyl group relative to the benzene ring. Notably, intermolecular hydrogen bonding generates an infinite polymeric chain, with additional weak hydrogen bonds observed in the crystal packing. The compound has potential applications in medicinal chemistry due to the biological activity of thioureas.

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1,1-Diethyl-3-(4-methoxybenzoyl)thiourea

Acta Crystallographica Section E Structure Reports Online, 2011

Key indicators: single-crystal X-ray study; T = 150 K; mean (C-C) = 0.003 Å; R factor = 0.042; wR factor = 0.132; data-to-parameter ratio = 15.6. organic compounds o3414 Al-abbasi et al.

3-(2-Hydroxyethyl)-3-methyl-1-(4-methylbenzoyl)thiourea

IUCrData, 2016

The title thiourea derivative, C12H16N2O2S, has a twisted conformation with the dihedral angle between the NC(=S)N and O=CC6planes being 35.45 (5)°. The observed conformation allows for an intramolecular N—H...O hydrogen bond. In the molecular packing, supramolecular aggregation is based on hydroxy-O—H...O(carbonyl) hydrogen bonding and leads to supramolecular helical chains along theaaxis; chains are reinforced byN-methylene-C—H...S andN-methyl-C—H...π(arene) interactions. Supramolecular layers in theabplane are formed as a result of tolyl-methyl-C—H...π(arene) interactions.

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